DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and LRRC26

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001013675.1 Gene:LRRC26 / 389816 HGNCID:31409 Length:334 Species:Homo sapiens


Alignment Length:265 Identity:86/265 - (32%)
Similarity:115/265 - (43%) Gaps:48/265 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 RPRLPLHLHLLL------W--LLCCCSQLGQLRA-ECPAVCECKWKSGKESVLCLNANLTHIPQP 107
            ||| ||.|.|||      |  :....|..|.|.| :||.||.|. ..|..|  |...:|..:|..
Human     8 RPR-PLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCV-PGGLAS--CSALSLPAVPPG 68

  Fly   108 LDAGTQLLDLSGNEIQLIPDDSFATA---QLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQ 169
            |....:.|.|..|.::.:|..:||.|   |.|:|::..|...|:|     ||..|..|..||||.
Human    69 LSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVR-----AFWGLGALQLLDLSA 128

  Fly   170 NLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESS 234
            |.|.|:.......:..||.|.|:||.:.|:...|.|.:|.|..|.|.|                 
Human   129 NQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQD----------------- 176

  Fly   235 LEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPT--CES 297
                    |.|:.:..|.:..|.:|..|.|..|.|.|.|:||||.||:.:..:|:....|  |..
Human   177 --------NELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVW 233

  Fly   298 PPRLS 302
            |.||:
Human   234 PGRLT 238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 45/159 (28%)
leucine-rich repeat 112..137 CDD:275380 8/27 (30%)
LRR_8 137..196 CDD:290566 21/58 (36%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 15/60 (25%)
leucine-rich repeat 186..209 CDD:275380 9/22 (41%)
leucine-rich repeat 210..234 CDD:275380 4/23 (17%)
leucine-rich repeat 235..258 CDD:275380 4/22 (18%)
LRRCT 267..316 CDD:214507 16/38 (42%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
LRRC26NP_001013675.1 LRR 1 72..93 5/20 (25%)
LRR 2 96..117 8/25 (32%)
LRR_RI 97..>253 CDD:238064 54/172 (31%)
LRR_8 97..155 CDD:290566 23/62 (37%)
leucine-rich repeat 97..120 CDD:275380 9/27 (33%)
LRR 3 120..141 8/20 (40%)
leucine-rich repeat 121..144 CDD:275380 8/22 (36%)
LRR_8 143..202 CDD:290566 21/83 (25%)
LRR 4 144..167 9/22 (41%)
leucine-rich repeat 145..168 CDD:275380 9/22 (41%)
LRR 5 168..190 7/46 (15%)
leucine-rich repeat 169..192 CDD:275380 8/47 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..334
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141308
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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