DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and swi2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_611247.3	Gene:	swi2 / 37010	FlyBaseID:	FBgn0034262	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	60/306 - (19%)
Similarity:	104/306 - (33%)	Gaps:	125/306 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 ECKWKSGKESVLCLNANL---THIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLAR 145
            :|:......:..||..::   ||||                                   :|...
  Fly   262 QCQSHEDLRNCTCLMHHILPKTHIP-----------------------------------LYTVN 291

  Fly   146 C-HLRLIERHAFRKL-----INLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAF 204
            | ||:      |.:|     .|...|.::.|::|.|                  ||:...|
  Fly   292 CSHLQ------FHRLPDFLPDNTTTLVINDNMISDI------------------NPLRDNP---- 328

  Fly   205 GHVPQLVKLELSDCRLSHIAVRAFAGLESSLE---WLK------LDGNRLSEVR----SGTITSL 256
             |...:|.::|.:.::|::         .:||   ||:      |.||.|.::.    ...:...
  Fly   329 -HYRHVVDMQLENNQISNV---------DNLEDTYWLQNFRLLNLRGNNLRKLHVYALDNALDDN 383

  Fly   257 ASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWD-----KLDVDDFAC 316
            .:.:.|.|:||.|:|:|........:|.:.            ..:...||:     :||.|
  Fly   384 ENANLLLLSRNPWHCTCKFGSRMRELLTKY------------KDIVRDAWNVSCTYRLDDD---- 432

  Fly   317 VPQIVATDTTAHGVEGRNITMSCYVEGVPQ-PAVKWLLKNRLIANL 361
              |::|...|....|..|::    |||..| ..:.||  |.::|:|
  Fly   433 --QLLAKVLTLSRQEMCNLS----VEGGTQIHPIDWL--NGVLASL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	28/175 (16%)
		leucine-rich repeat	112..137	CDD:275380	0/24 (0%)
		LRR_8	137..196	CDD:290566	12/64 (19%)
		leucine-rich repeat	138..161	CDD:275380	6/28 (21%)
		leucine-rich repeat	162..185	CDD:275380	4/22 (18%)
		LRR_8	184..245	CDD:290566	14/69 (20%)
		leucine-rich repeat	186..209	CDD:275380	4/22 (18%)
		leucine-rich repeat	210..234	CDD:275380	3/23 (13%)
		leucine-rich repeat	235..258	CDD:275380	8/35 (23%)
		LRRCT	267..316	CDD:214507	10/53 (19%)
		IG_like	328..428	CDD:214653	11/35 (31%)
		Ig	335..425	CDD:143165	9/28 (32%)
swi2	NP_611247.3	LRR	<117..384	CDD:227223	33/194 (17%)
		leucine-rich repeat	132..154	CDD:275378
		leucine-rich repeat	155..178	CDD:275378
		leucine-rich repeat	179..201	CDD:275378
		leucine-rich repeat	202..214	CDD:275378
		leucine-rich repeat	287..307	CDD:275378	6/25 (24%)
		leucine-rich repeat	308..332	CDD:275378	8/46 (17%)
		leucine-rich repeat	333..357	CDD:275378	7/32 (22%)
		leucine-rich repeat	358..385	CDD:275378	4/26 (15%)
		leucine-rich repeat	386..398	CDD:275378	5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100