DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Lrrc24

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001129368.1 Gene:Lrrc24 / 362945 RGDID:1308720 Length:521 Species:Rattus norvegicus


Alignment Length:474 Identity:136/474 - (28%)
Similarity:195/474 - (41%) Gaps:86/474 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 LRPRLPLHLHLLLWLLC--CCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQ 113
            :.|..|..|.|||.||.  ....|......|||.|.|.    ..:|.|....|..:|..:..|||
  Rat     1 MAPGPPALLLLLLGLLLLPLLPGLPPRATGCPAACRCY----SATVECGALRLRVVPPGIPPGTQ 61

  Fly   114 LLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSL 178
            .|.|..|.|..:  :..|.|.|..|:.:||....||.:|..|||....|:||.|:.|.|..:...
  Rat    62 TLFLQDNSIAHL--EQGALAPLAALRHLYLHNNTLRALESGAFRAQPRLLELALTGNRLRGLRGG 124

  Fly   179 ALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGN 243
            |...:.:||.|.|:||.:.::.|..|.|:|:|.:|.|.:..:..:..:|.||| |||..|.|..|
  Rat   125 AFVGLVQLRVLYLAGNQLAKLLDFTFLHLPRLQELHLQENSIELLEDQALAGL-SSLALLDLSRN 188

  Fly   244 RLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM------LQQNIPSGIPPTCESPPRLS 302
            :|..:....:..|:||..|.|..|.|.|.|:|..|.:|:      |..:....|  ||..||||:
  Rat   189 QLGTISKEALQPLSSLQVLRLTENPWRCDCALHWLGSWIKEGGRRLLSSRDKKI--TCAEPPRLA 251

  Fly   303 GRAWDKLDVDDFACVPQIV---ATDTTAHGVEGRNITMSCYVEGVPQPAVKW--LLKNRLIANLS 362
            .::..::......|:|..|   ..:.||:  .|.::.::|...|.|||.|.|  :|:.|      
  Rat   252 LQSLLEVSGGSLICIPPSVNAEPPELTAN--LGEDLQVACQASGYPQPLVVWRKMLQPR------ 308

  Fly   363 AGGDGDSDSEPRTAAATQG----------RKTYVVNMLRNASNLTILT-ADMQDAGIYTCAAENK 416
                   |.:|:.....:|          |.|        .|.:..|| ..:..||.|.|.|.|.
  Rat   309 -------DGKPQAQVQLEGGAPGLGGHATRDT--------GSGMLFLTNITLAHAGKYECEATNA 358

  Fly   417 AGKV---------------------EASVTLAVSRRPPEAPWGVRIILLG--------AVAALLL 452
            .||.                     :|..|..|.:.|......:....||        |..|||.
  Rat   359 GGKARVLFHLLVNASRQQSQQLPAPQAPATRPVGQEPQHEGGSMAFRALGLATQTAITAAIALLA 423

  Fly   453 VGGSSFAAICLCSLQRRRK 471
            :.....||: :|..:||||
  Rat   424 LTALLLAAM-ICRRRRRRK 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 55/156 (35%)
leucine-rich repeat 112..137 CDD:275380 9/24 (38%)
LRR_8 137..196 CDD:290566 22/58 (38%)
leucine-rich repeat 138..161 CDD:275380 9/22 (41%)
leucine-rich repeat 162..185 CDD:275380 7/22 (32%)
LRR_8 184..245 CDD:290566 23/60 (38%)
leucine-rich repeat 186..209 CDD:275380 9/22 (41%)
leucine-rich repeat 210..234 CDD:275380 7/23 (30%)
leucine-rich repeat 235..258 CDD:275380 6/22 (27%)
LRRCT 267..316 CDD:214507 15/54 (28%)
IG_like 328..428 CDD:214653 28/133 (21%)
Ig 335..425 CDD:143165 26/123 (21%)
Lrrc24NP_001129368.1 leucine-rich repeat 61..83 CDD:275380 8/23 (35%)
PPP1R42 63..>212 CDD:411060 52/151 (34%)
LRR_8 84..142 CDD:404697 22/57 (39%)
leucine-rich repeat 84..107 CDD:275380 9/22 (41%)
leucine-rich repeat 108..131 CDD:275380 7/22 (32%)
leucine-rich repeat 132..155 CDD:275380 9/22 (41%)
leucine-rich repeat 156..179 CDD:275380 7/23 (30%)
leucine-rich repeat 180..203 CDD:275380 6/22 (27%)
PCC 188..>259 CDD:188093 22/72 (31%)
Ig_3 267..357 CDD:404760 27/112 (24%)
Ig strand A 267..271 CDD:409353 1/3 (33%)
Ig strand A' 276..280 CDD:409353 1/3 (33%)
Ig strand B 283..292 CDD:409353 1/8 (13%)
Ig strand C 298..304 CDD:409353 2/5 (40%)
Ig strand D 330..333 CDD:409353 1/2 (50%)
Ig strand E 336..342 CDD:409353 1/5 (20%)
Ig strand F 349..357 CDD:409353 4/7 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335007
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45224
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.900

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