DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Tril

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001029182.1	Gene:	Tril / 362364	RGDID:	1310827	Length:	811	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	125/499 - (25%)
Similarity:	176/499 - (35%)	Gaps:	189/499 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 WLLCCCSQLGQLRAE--CPAVCECKWKSGKESVLCLNANL------THIPQPLDAGT-------- 112
            ||:.|.......|||  ||..|:|:   ..:.:||.|..|      :.:|.|.|..|
  Rat    10 WLVVCGCLAFPPRAESVCPERCDCQ---HPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFI 71

  Fly   113 ------------QL--LDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRL------------- 150
                        ||  |||..|:|:.:...:|  .:|..|:::||....|:.
  Rat    72 TNITAFDFHRLGQLRRLDLQYNQIRSLHPKTF--EKLSRLEELYLGNNLLQALAPGTLAPLRKLR 134

  Fly   151 -----------IERHAFRKLINLVELDLSQNLLSAIPSL------------------------AL 180
                       :.|.:|..|.:||:|.|..|:|.|:|..                        |.
  Rat   135 ILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEANRIRFLGKNAF 199

  Fly   181 YHVSELRELRLSGN---PILR-----VP------------------DDAFGHVPQLVKLELSDCR 219
            ..:.:||.|.||.|   |.||     ||                  ...|.|:|:|..|.||..:
  Rat   200 TQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQ 264

  Fly   220 LSHIAVRAFAGLES-----------------------SLEWLKLDGNRLS--------------- 246
            |:|:|..||.|||:                       |||.|.|.||.||
  Rat   265 LTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRE 329

  Fly   247 -EVRSGTITSLA--------SLHGLELARNTWNCSCSLRPLRAWM---LQQNIPSGIPPTCESPP 299
             .:|...:::|:        :|:.|:|..|.|.|.|.||.|:.||   ..|.....:...|..||
  Rat   330 LSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRHPP 394

  Fly   300 RLSGRAWDKLD---VDDFACV---PQIVATD-----TTAHGVEG----RNITMSCYVEGVPQP-- 347
            .|.|:..|.||   :.:.:||   |...|..     :||.| ||    ..:.....::..|||
  Rat   395 ALRGKYLDYLDDQLLQNGSCVDPSPSPTAGSRQWPISTAPG-EGMTPPAGLAQELPLQPQPQPQQ 458

  Fly   348 ------------AVKWLLKNRLIANLSAGGDGDSDSEPRTAAAT 379
                        |.|.|:.||....|:..|.|.....|..|||:
  Rat   459 RGRLLPGVAWAGAAKELVGNRSALRLNRRGPGLQHQSPSAAAAS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	66/299 (22%)
		leucine-rich repeat	112..137	CDD:275380	10/46 (22%)
		LRR_8	137..196	CDD:290566	22/109 (20%)
		leucine-rich repeat	138..161	CDD:275380	7/46 (15%)
		leucine-rich repeat	162..185	CDD:275380	9/46 (20%)
		LRR_8	184..245	CDD:290566	33/109 (30%)
		leucine-rich repeat	186..209	CDD:275380	13/48 (27%)
		leucine-rich repeat	210..234	CDD:275380	12/46 (26%)
		leucine-rich repeat	235..258	CDD:275380	10/46 (22%)
		LRRCT	267..316	CDD:214507	18/54 (33%)
		IG_like	328..428	CDD:214653	18/70 (26%)
		Ig	335..425	CDD:143165	15/59 (25%)
Tril	NP_001029182.1	LRR_RI	22..313	CDD:238064	73/295 (25%)
		leucine-rich repeat	37..57	CDD:275378	4/19 (21%)
		LRR 1	61..81		1/19 (5%)
		LRR_8	84..143	CDD:290566	13/60 (22%)
		LRR 2	84..105		8/22 (36%)
		leucine-rich repeat	85..108	CDD:275380	8/24 (33%)
		LRR 3	108..129		4/20 (20%)
		leucine-rich repeat	109..132	CDD:275380	4/22 (18%)
		LRR 4	132..153		2/20 (10%)
		leucine-rich repeat	133..156	CDD:275380	3/22 (14%)
		LRR_8	156..215	CDD:290566	15/58 (26%)
		LRR 5	156..177		8/20 (40%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		LRR 6	180..201		1/20 (5%)
		leucine-rich repeat	181..204	CDD:275380	1/22 (5%)
		LRR 7	204..223		9/18 (50%)
		leucine-rich repeat	205..230	CDD:275380	11/24 (46%)
		LRR_8	229..289	CDD:290566	15/59 (25%)
		LRR 8	230..251		1/20 (5%)
		leucine-rich repeat	231..254	CDD:275380	2/22 (9%)
		LRR 9	254..275		9/20 (45%)
		leucine-rich repeat	255..278	CDD:275380	11/22 (50%)
		LRR 10	278..298		0/19 (0%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	302..359	CDD:290566	14/56 (25%)
		LRR 11	302..323		9/20 (45%)
		leucine-rich repeat	303..323	CDD:275380	8/19 (42%)
		LRR 12	326..347		2/20 (10%)
		leucine-rich repeat	327..340	CDD:275378	1/12 (8%)
		leucine-rich repeat	351..363	CDD:275378	5/11 (45%)
		TPKR_C2	359..406	CDD:301599	17/46 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..460		12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..562		6/17 (35%)
		FN3	589..661	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930