DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lgi4

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_955793.1	Gene:	Lgi4 / 361549	RGDID:	735035	Length:	537	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	110/525 - (20%)
Similarity:	172/525 - (32%)	Gaps:	170/525 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQK 140
            :.:||..|.|    .|||.||..:     |:                  :| :||:|. ||:|.
  Rat    24 KGKCPPRCSC----SKESTLCEGS-----PE------------------LP-ESFSTT-LLSLS- 58

  Fly   141 VYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFG 205
              |.|..:..::..:|.|:                |||.|        |..:.|....:..|||.
  Rat    59 --LVRMGVSRLKAGSFLKM----------------PSLHL--------LLFTSNTFSVIEGDAFI 97

  Fly   206 HVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWN 270
            .:..|..|.:.|.::..|:..|..||. ||..|.|..|.|..:.......|.:|..::|..|.:.
  Rat    98 GLSYLQYLFIEDNKIGSISKNALRGLR-SLTHLSLANNHLEALPRFLFQGLETLTHVDLRGNPFQ 161

  Fly   271 CSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNI 335
            |.|.:..|..||...|...| ...|..|..|:....:.||...|.|    .||:.:
  Rat   162 CDCRVLWLLQWMPMVNASVG-TGACAGPSALAQIQLNHLDPKKFKC----KATELS--------- 212

  Fly   336 TMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILT 400
                :::.|.:.|:.       :.:.|..|      ||....|..           .|....||
  Rat   213 ----WLQTVGESALS-------VESFSYQG------EPHMVLAQP-----------FAGRCLIL- 248

  Fly   401 ADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCS 465
                   ::..:.:....:.|.|....||.:|  ...|.|:.:|.|    .|.|||
  Rat   249 -------VWDYSLQRFRSEEELSAPSVVSCKP--LVLGPRLFILAA----RLWGGS--------- 291

  Fly   466 LQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAE------EQG 524
                   :||:...|..|....:.:......||                   :|||      :..
  Rat   292 -------QLWSRSSPDLRLTPVQVLAPQRLLRP-------------------NDAELLWLDGQPC 330

  Fly   525 YLRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHP-------QQQ 582
            ::.|     :.:.||....:.....|...|::   || :.|.|.:.|..:|...|       .|:
  Rat   331 FVVA-----DASKAGSTTLLCRDGPGFYPRQS---LH-AWHRDTDAEALELDGRPHLLLASASQR 386

  Fly   583 PASQH 587
            |...|
  Rat   387 PVLFH 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	36/156 (23%)
		leucine-rich repeat	112..137	CDD:275380	5/24 (21%)
		LRR_8	137..196	CDD:290566	11/58 (19%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	4/22 (18%)
		LRR_8	184..245	CDD:290566	17/60 (28%)
		leucine-rich repeat	186..209	CDD:275380	5/22 (23%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	14/48 (29%)
		IG_like	328..428	CDD:214653	12/99 (12%)
		Ig	335..425	CDD:143165	12/89 (13%)
Lgi4	NP_955793.1	leucine-rich repeat	54..77	CDD:275378	7/41 (17%)
		LRR_8	76..136	CDD:290566	21/68 (31%)
		leucine-rich repeat	78..101	CDD:275378	7/30 (23%)
		LRR_4	102..140	CDD:289563	13/38 (34%)
		leucine-rich repeat	102..125	CDD:275378	7/23 (30%)
		leucine-rich repeat	126..149	CDD:275378	6/22 (27%)
		leucine-rich repeat	150..162	CDD:275378	3/11 (27%)
		LRRCT	158..207	CDD:214507	15/53 (28%)
		EPTP	<220..251	CDD:281697	9/62 (15%)
		EPTP	351..392	CDD:281697	12/45 (27%)
		EPTP	396..438	CDD:281697
		EPTP	441..482	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840