DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and rdo

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	167/855 - (19%)
Similarity:	265/855 - (30%)	Gaps:	333/855 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLWLLCCC-SQLGQLRAECPAVCECKWKS-GKESVLCLNANLTHI--PQPLDAGTQLLDLSG--N 120
            ||:.||.. :.....:.:||..|:|.... .:...:|....|..:  |..||...:::.:.|  |
  Fly     6 LLFSLCIMPAMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGPRN 70

  Fly   121 EIQLIPDDSFATAQLLNLQ--------------KVYLARCHLRLIE----------RHAFRKLIN 161
            .|.:.|    |..|.:.|:              :.:....:||:::          .:.||...|
  Fly    71 SITIGP----ALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDN 131

  Fly   162 LVELDLSQNLLSAIPSLALYHVSELRELR------------------------LSGNPILRVPDD 202
            |:|||||:|.:..:.|....|:::||.|.                        |||||:..:..|
  Fly   132 LLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPD 196

  Fly   203 AFGHVPQLVKLELSDCRLSHI-------------------------------------------- 223
            .|..||:|..|:..:|:|..|
  Fly   197 VFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQ 261

  Fly   224 ---AVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARN-----------------T 268
               .|.....::.||..|.|..|||::|.:.:...|.:|..|:|:.|                 |
  Fly   262 LSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLT 326

  Fly   269 WNCS----CSLRPLR--------------AWMLQQNIPS---------GIPPTCESPP------- 299
            .|.|    ..||.:|              :.:..|.||.         |..|.....|
  Fly   327 LNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYL 391

  Fly   300 RLSGRAWDK--LDVDDFAC--VPQIVATDTTAHG--------VEG-RNITM--------SCY--- 340
            .:||.:.:.  |:|.| .|  :..:..:....||        ::| ||:.:        .|:
  Fly   392 NISGNSLNNTALEVID-PCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGK 455

  Fly   341 -VEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNA--SNLTILTAD 402
             :..|.|...||                  |:.|         ..::...||.|  :||.|
  Fly   456 LINVVRQLQWKW------------------DTYP---------ICFLPKSLRGAEINNLDI---- 489

  Fly   403 MQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQ 467
               .|::||            :|.........|......:..|.:..|.::||..|..|.:..|.
  Fly   490 ---NGLHTC------------LTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILS 539

  Fly   468 -----RRRKLRLWNSVPPVRRSES--YEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGY 525
                 .:.:.|.:.....:..|||  .|| .:.|.|...||.|:|
  Fly   540 LVACFSKNRARYYTREDHLNGSESKCLEK-NLEATTITTLGNGSS-------------------- 583

  Fly   526 LRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVS-------THCDDEEEDQQLHH------ 577
                  |........|   .:|:|.:..:.||..|.:|       .|...:::.::::.
  Fly   584 ------PTTTTTLTLA---TSPAAPNGPKTNGQGLSLSPANGSTPVHGISDDKGKEINFTFPVDD 639

  Fly   578 --------HPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGT 634
                    .|...|..|.|||||.       ||..:.||               |.|.
  Fly   640 RVCTIDELMPSPPPPPQQHPHPNM-------GSLMYSVS---------------HSPN------- 675

  Fly   635 DSASSSISSQVDAAARL--AGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGN 697
               |::..:.|.|||.:  .|...|:...||..|     |....|....|..|    .|..|:
  Fly   676 ---SATTLAAVAAAATVIPPGAPSHSSMPTPTPT-----PAEAVVVVLPPPPL----PPQQHH-- 726

  Fly   698 HPADEMATSV 707
            |..|....|:
  Fly   727 HQMDGSLASL 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	51/253 (20%)
		leucine-rich repeat	112..137	CDD:275380	6/26 (23%)
		LRR_8	137..196	CDD:290566	22/106 (21%)
		leucine-rich repeat	138..161	CDD:275380	5/46 (11%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	23/131 (18%)
		leucine-rich repeat	186..209	CDD:275380	11/46 (24%)
		leucine-rich repeat	210..234	CDD:275380	6/70 (9%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	18/101 (18%)
		IG_like	328..428	CDD:214653	22/122 (18%)
		Ig	335..425	CDD:143165	16/103 (16%)
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	1/22 (5%)
		leucine-rich repeat	108..131	CDD:275380	4/22 (18%)
		LRR_8	131..190	CDD:290566	17/58 (29%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		LRR_RI	151..422	CDD:238064	50/271 (18%)
		leucine-rich repeat	156..179	CDD:275380	3/22 (14%)
		LRR_8	178..262	CDD:290566	14/83 (17%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..251	CDD:275380	5/46 (11%)
		leucine-rich repeat	252..275	CDD:275380	1/22 (5%)
		LRR_8	274..334	CDD:290566	16/59 (27%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		LRR_4	298..342	CDD:289563	9/43 (21%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		leucine-rich repeat	388..411	CDD:275380	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100