DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and kek1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	263/927 - (28%)
Similarity:	398/927 - (42%)	Gaps:	172/927 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PGPPSGQDIASDNSAQRRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRA 77
            |.|.|..::.|...:|            |..:....||.:...|.|..|        ....|.::
  Fly    44 PAPSSQNEVYSIADSQ------------PMTEDGYMPPSQHFPPTHSDL--------DPPAQQQS 88

  Fly    78 ECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVY 142
            .|..||.||||.||::|.|::.:|..||:.:|..||:||:|||::|.:.::.|..|.||||||:|
  Fly    89 TCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLY 153

  Fly   143 LARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHV 207
            |..|.:..|||..|:.|.||||||||.|||..:|||||.|:..||||.|:.|.|.::...|||:.
  Fly   154 LRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNT 218

  Fly   208 PQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCS 272
            |.|.||:||.|.:..|:.:||.||: .|..|:|:||:|||:...||.:|:.|||:||..|.|.|.
  Fly   219 PSLHKLDLSHCDIQTISAQAFGGLQ-GLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCD 282

  Fly   273 CSLRPLRAWMLQQNIPSGIPPTCE-SPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNIT 336
            |.||..:.|::::|||..:.|.|. .|.|:..|::..|.||:|||.|:::..........|.|.:
  Fly   283 CRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAMGENAS 347

  Fly   337 MSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNA----SNLT 397
            ::|....||...:.|....||:||              .:|.|..::.:::..:...    |.|.
  Fly   348 ITCRARAVPAANINWYWNGRLLAN--------------NSAFTAYQRIHMLEQVEGGFEKRSKLV 398

  Fly   398 ILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAPWGV-RIILLGAVAALLLVGGSSFA- 459
            :..|...|:..:.|.|||:||..||:.||.||.|.. .|..|. :|:.|.|....|:|    ||
  Fly   399 LTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIV----FAL 459

  Fly   460 AICLCSLQRRRKLRLWNSVPP----VRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDA 520
            .:.:|.|.|.::....:|..|    |..|.:::. .:|.:|:|..|.|:..|...|.||
  Fly   460 GVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQN-SITNKTQPATGNGSIGGVVIANGA------ 517

  Fly   521 EEQGYLRAAHTPLNDNDAG--QAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQP 583
                       ..|..|.|  |...:...|:|.....:|  :|          ||:..:..|:.|
  Fly   518 -----------VANIIDGGVVQGGTLERKSSGRGGVPHG--VH----------DQRSANPVQKPP 559

  Fly   584 ASQHHPHPNQQQHQQRKGSQGHVVS------------ASGANNSAPLEET---------DLHIPR 627
            .....|:..|..     .:.|.|:|            .:|.||...:.:|         ||.||.
  Fly   560 RLTDLPYSTQGY-----DNNGSVLSTASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPP 619

  Fly   628 LIDIGGTDSASSSISSQVDAAARLAGYAGHTWK-TTPIATTKINSPHSKPVTSAAPSSLNTQATP 691
            :..:|...|...|.::..|:.     |....|: ..|:.||..:....|..|...|...:||.
  Fly   620 ISGVGVGGSGEYSRANGCDSL-----YPSGLWEHGAPVGTTSADDLFMKRYTDKTPIIDSTQL-- 677

  Fly   692 YAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQA---TTTPN 753
               |..|           .....:|.|...:|      :..:.|....|.|.|.:.|   ||..:
  Fly   678 ---YDLH-----------ERTAATDYFSKTFP------RSHLQQGMMTGGGGGTSTASTVTTNLS 722

  Fly   754 GGLCT-------LPRKLKTSGKYFRNSSDSQSPL---------LADNSSKYGSSTLGDGSFLNEA 802
            ||..:       ||  |....::..|......||         ..::..:.||||.....|.:..
  Fly   723 GGSSSGYPNDYGLP--LVPGAEHQHNHQLQMHPLQQLQQQLTSTLNHQKQEGSSTGSSPHFSSRT 785

  Fly   803 MGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGKLLPS---------HLGQKPSL 858
              |.|.:.......:..|:.|....|..||...| ..:.:....:||:         .:.||..:
  Fly   786 --LPRLHEGSGGGGSSRSSPTPAVSGGHANQAAN-PSTSSSSCSILPNGQPINAKTIRVWQKGGV 847

  Fly   859 PSSP--VQHQRSLSSAA 873
            |..|  ...:|:|.|::
  Fly   848 PVLPPVTALKRALISSS 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	79/156 (51%)
		leucine-rich repeat	112..137	CDD:275380	11/24 (46%)
		LRR_8	137..196	CDD:290566	35/58 (60%)
		leucine-rich repeat	138..161	CDD:275380	11/22 (50%)
		leucine-rich repeat	162..185	CDD:275380	16/22 (73%)
		LRR_8	184..245	CDD:290566	27/60 (45%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	11/23 (48%)
		leucine-rich repeat	235..258	CDD:275380	11/22 (50%)
		LRRCT	267..316	CDD:214507	19/49 (39%)
		IG_like	328..428	CDD:214653	26/103 (25%)
		Ig	335..425	CDD:143165	22/93 (24%)
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	80/158 (51%)
		leucine-rich repeat	123..148	CDD:275380	11/24 (46%)
		LRR_8	148..207	CDD:290566	35/58 (60%)
		leucine-rich repeat	149..172	CDD:275380	11/22 (50%)
		leucine-rich repeat	173..196	CDD:275380	16/22 (73%)
		LRR_8	195..255	CDD:290566	27/60 (45%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		leucine-rich repeat	221..244	CDD:275380	11/23 (48%)
		leucine-rich repeat	245..268	CDD:275380	11/22 (50%)
		LRRCT	277..327	CDD:214507	19/49 (39%)
		IG_like	338..429	CDD:214653	26/104 (25%)
		Ig	346..426	CDD:143165	22/93 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12164
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23311at33392
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020