DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LRIT3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	820	Identity:	179/820 - (21%)
Similarity:	280/820 - (34%)	Gaps:	228/820 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQLGQLRAECPAVCECKWK-----SGKESVLCLNANLTHIPQPLDAGTQLLDLS 118
            :||...|....|.|..:...||:.|.|.:.     ||...|||.:.::..:|..|...|..|.:.
Human     1 MHLFACLCIVLSFLEGVGCLCPSQCTCDYHGRNDGSGSRLVLCNDMDMNELPTNLPVDTVKLRIE 65

  Fly   119 GNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHV 183
            ...|:.|..::|  ..|:.||.:::....:..|:..:|..|..|.||.|..|.|:|.|..:|..:
Human    66 KTVIRRISAEAF--YYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDM 128

  Fly   184 SELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEV 248
            ..||.|.|..|.|..||::|..::..|..|:||..||:.:....   |||   |     ..|...
Human   129 PLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDF---LES---W-----THLVST 182

  Fly   249 RSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPP---------TCESPPRLSGR 304
            .||.:....|...|.|..|.|.|.|.:    :.|::  :...:.|         ||..|.||:|.
Human   183 PSGVLDLSPSRIILGLQDNPWFCDCHI----SKMIE--LSKVVDPAIVLLDPLMTCSEPERLTGI 241

  Fly   305 AWDKLDVDDFACV-PQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGD 368
            .:.:.:::.  |: |.::.:.|......|.|:.:.|...|.|.|.:.|.               .
Human   242 LFQRAELEH--CLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWT---------------R 289

  Fly   369 SDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAV----- 428
            |||.|......|......|..    |.:::.....:|||.|.|.|:|.||..||.||:.|
Human   290 SDSSPVNYTVIQESPEEGVRW----SIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITT 350

  Fly   429 -------SRRPPEAP-WGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSE 485
                   |.|..:.| |.|:   .|:..:..:...||:               ||:|
Human   351 TPIPPDTSERTGDHPEWDVQ---PGSGRSTSVSSASSY---------------LWSS-------- 389

  Fly   486 SYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAI---VNP 547
            |:.         |.....||.....:|.:             .:.:|.:.:.......:   ::.
Human   390 SFS---------PTSSFSASTLSPPSTAS-------------FSLSPFSSSTVSSTTTLSTSISA 432

  Fly   548 SAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGA 612
            |...|.:|                            :.|.|....:.....:.||:....|.|..
Human   433 STTMANKR----------------------------SFQLHQGGKRNLKVAKNGSKLPPASTSKK 469

  Fly   613 NNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPV 677
            ...|.|::|.|                   ::.:||.........|.::..:....||:.|:..|
Human   470 EELALLDQTML-------------------TETNAAIENLRVVSETKESVTLTWNMINTTHNSAV 515

  Fly   678 TSA-------------APSSLNTQAT-----PYAHY-------GNHPADEMATSVFCSEGQESDL 717
            |..             |.||.| |.|     |...|       |..|..:...: |.:|..|.|
Human   516 TVLYSKYGGKDLLLLNADSSKN-QVTIDGLEPGGQYMACVCPKGVPPQKDQCIT-FSTERVEGD- 577

  Fly   718 FDSNYPDLLDIAK--------------YAVAQAQQEGR--------GQGYAQATTTPNGGLCTLP 760
             ||.:..||.:..              |.|.:.|.:..        .:.|.|..|       ..|
Human   578 -DSQWSLLLVVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFET-------LFP 634

  Fly   761 RKLKTSGKYFRNS--SDSQSPLLADNSSKYGSSTL-GDGS 797
            |. ::.|:.:..|  .||:..||...||.....|. .:||
Human   635 RS-QSVGELWTRSHRDDSEKLLLCSRSSVESQVTFKSEGS 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	45/156 (29%)
		leucine-rich repeat	112..137	CDD:275380	6/24 (25%)
		LRR_8	137..196	CDD:290566	19/58 (33%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	19/60 (32%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	4/22 (18%)
		LRRCT	267..316	CDD:214507	12/57 (21%)
		IG_like	328..428	CDD:214653	27/99 (27%)
		Ig	335..425	CDD:143165	23/89 (26%)
LRIT3	NP_940908.3	LRR 1	56..79		5/24 (21%)
		leucine-rich repeat	59..82	CDD:275378	6/24 (25%)
		LRR_8	61..117	CDD:290566	15/57 (26%)
		LRR 2	80..103		5/22 (23%)
		leucine-rich repeat	83..106	CDD:275378	5/22 (23%)
		LRR 3	104..128		10/23 (43%)
		LRR_8	105..165	CDD:290566	22/59 (37%)
		LRR_4	105..146	CDD:289563	16/40 (40%)
		leucine-rich repeat	107..130	CDD:275378	9/22 (41%)
		LRR 4	129..151		9/21 (43%)
		LRR_4	131..170	CDD:289563	15/38 (39%)
		leucine-rich repeat	131..154	CDD:275378	9/22 (41%)
		LRR 5	152..175		7/25 (28%)
		leucine-rich repeat	155..168	CDD:275378	6/12 (50%)
		Ig	267..345	CDD:299845	27/96 (28%)
		IG_like	267..345	CDD:214653	27/96 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		6/26 (23%)
		FN3	486..550	CDD:214495	14/64 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840