DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LINGO4

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001004432.1	Gene:	LINGO4 / 339398	HGNCID:	31814	Length:	593	Species:	Homo sapiens

Alignment Length:	638	Identity:	153/638 - (23%)
Similarity:	213/638 - (33%)	Gaps:	225/638 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQ 113
            ||..|        ||:||......|   ..|||||:|  .|..::|||.:..|..:|..|...|:
Human    12 PPWPP--------LLFLLLLPGGSG---GSCPAVCDC--TSQPQAVLCGHRQLEAVPGGLPLDTE 63

  Fly   114 LLDLSG----------------------------------------------------------- 119
            ||||||
Human    64 LLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVF 128

  Fly   120 -------------NEIQLIPDDSF----------------------ATAQLLNLQKVYLARCHLR 149
                         |:|.|..|.:|                      |.|.|..|..:.|.||:|.
Human   129 SGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLS 193

  Fly   150 LIERHAFRKL-----INLVELDLSQ----------------------------------NL---- 171
            .:...|..:|     :.|.|||:.:                                  ||
Human   194 TVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLA 258

  Fly   172 -----LSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGL 231
                 ||::|..||||:|.||.|.||.|||..:|......:.:|.:|.||...|:.||..||.||
Human   259 ITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGL 323

  Fly   232 ESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM--LQQNIPSGI-PP 293
             ::...|.:..|.|..:......|...|..|.|:.|...|.|.|    .|:  |::::..|: ||
Human   324 -TAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRL----LWLLRLRRHLDFGMSPP 383

  Fly   294 TCESPPRLSGRAW----DKLDVDDFACVPQIVATDTTAHGV--EGRNITMSCYVEGVPQPAVKWL 352
            .|..|..:.|::.    |.|....|.|.|.::........:  ||.:...||..:|.|.|.|.|:
Human   384 ACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWM 448

  Fly   353 LKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKA 417
                                 |...|..||... |.:|.:.: |.|.:..::|.|.|.|...|.|
Human   449 ---------------------RPHGAWLGRAGR-VRVLEDGT-LEIRSVQLRDRGAYVCVVSNVA 490

  Fly   418 GKVEASVTLAVSRRPPEAPWGV----RIILLG----------AVAALLLVGGSSF-AAICLCSLQ 467
            |.......|.|.:..|  |.|.    .|.:.|          .||.:|.||...| .::.||.
Human   491 GNDSLRTWLEVIQVEP--PNGTLSDPNITVPGIPGPFFLDSRGVAMVLAVGFLPFLTSVTLCF-- 551

  Fly   468 RRRKLRLWNSVPPVRRSESYEKIEMT---ARTRPDLGGGASCGGGSATGAGLF 517
              ..:.||:      :.:...|..||   ...||   .|....||:...|.||
Human   552 --GLIALWS------KGKGRVKHHMTFDFVAPRP---SGDKNSGGNRVTAKLF 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	63/298 (21%)
		leucine-rich repeat	112..137	CDD:275380	15/118 (13%)
		LRR_8	137..196	CDD:290566	27/106 (25%)
		leucine-rich repeat	138..161	CDD:275380	7/27 (26%)
		leucine-rich repeat	162..185	CDD:275380	13/65 (20%)
		LRR_8	184..245	CDD:290566	23/60 (38%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	11/23 (48%)
		leucine-rich repeat	235..258	CDD:275380	4/22 (18%)
		LRRCT	267..316	CDD:214507	15/55 (27%)
		IG_like	328..428	CDD:214653	25/101 (25%)
		Ig	335..425	CDD:143165	22/89 (25%)
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	14/34 (41%)
		leucine-rich repeat	62..85	CDD:275380	7/22 (32%)
		LRR_8	65..120	CDD:290566	5/54 (9%)
		leucine-rich repeat	86..109	CDD:275380	0/22 (0%)
		LRR_RI	87..320	CDD:238064	45/232 (19%)
		LRR_8	109..168	CDD:290566	5/58 (9%)
		leucine-rich repeat	110..133	CDD:275380	0/22 (0%)
		leucine-rich repeat	134..157	CDD:275380	5/22 (23%)
		LRR_8	157..212	CDD:290566	10/54 (19%)
		leucine-rich repeat	158..181	CDD:275380	3/22 (14%)
		leucine-rich repeat	182..205	CDD:275380	7/22 (32%)
		leucine-rich repeat	206..229	CDD:275380	4/22 (18%)
		leucine-rich repeat	230..277	CDD:275380	9/46 (20%)
		LRR_8	253..309	CDD:290566	22/55 (40%)
		leucine-rich repeat	278..301	CDD:275380	9/22 (41%)
		LRR_8	301..360	CDD:290566	19/59 (32%)
		leucine-rich repeat	302..325	CDD:275380	11/23 (48%)
		leucine-rich repeat	326..344	CDD:275380	3/17 (18%)
		leucine-rich repeat	350..362	CDD:275378	4/11 (36%)
		IG_like	420..501	CDD:214653	25/103 (24%)
		Ig	431..501	CDD:299845	23/92 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910