DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lgr6

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001028581.1	Gene:	Lgr6 / 329252	MGIID:	2441805	Length:	967	Species:	Mus musculus

Alignment Length:	1159	Identity:	235/1159 - (20%)
Similarity:	358/1159 - (30%)	Gaps:	403/1159 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LHPPLRPRLPLHLHLLLWL---LCCCS------QLGQLRAECPAVCECKWKSGKESVLCLNANLT 102
            :|.|  |.|     |.|||   ||..:      |.|..|..|||.|.|:......|..|....|:
Mouse     1 MHSP--PGL-----LALWLCAVLCASARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSELGLS 58

  Fly   103 HIPQPLDAGTQLLD------------------------LSGNEIQLIPDDSF------------- 130
            .:|..||..|..||                        ||||.:..||..:|
Mouse    59 VVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQS 123

  Fly   131 ---------ATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSEL 186
                     |..:|.:||.:.|....:.|:...:|..|.:|..|.|..|.|:.||..||.::..|
Mouse   124 NQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPAL 188

  Fly   187 RELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSG 251
            :.:.|:.|.|..:||.||.::..||.|.|.:.|:.|:...:|.||. :||.|.|:.|.|.|...
Mouse   189 QAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLH-NLETLDLNYNELQEFPL- 251

  Fly   252 TITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC 316
            .|.:|..|..|....|    :....|.:|:|              ..|.|.
Mouse   252 AIRTLGRLQELGFHNN----NIKAIPEKAFM--------------GSPLLQ-------------- 284

  Fly   317 VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQG 381
                     |.|..:..       ::.|.:.|.::|.|   :..||..|..|....|.
Mouse   285 ---------TIHFYDNP-------IQFVGRSAFQYLSK---LHTLSLNGATDIQEFPD------- 323

  Fly   382 RKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGA 446
                    |:..::|.|||                       :|.|          |:|::..|
Mouse   324 --------LKGTTSLEILT-----------------------LTRA----------GIRLLPPG- 346

  Fly   447 VAALLLVGGSSFAAICLCSLQRRRKLRLWNS----VPPVRRSESYEKIEMTARTRPDLGGGASCG 507
                          :|. .|.|.|.|.|.::    :|.:.|.:..|:|.:......::|......
Mouse   347 --------------VCQ-QLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQ 396

  Fly   508 GGSATGAGLFHDAEEQGYLRAAH------------TPLNDNDAGQAAAIVNPSAG---------- 550
            .||.....|..:|     :||.|            ..|.||   |...:  |.||
Mouse   397 LGSLQALDLSWNA-----IRAIHPEAFSTLRSLVKLDLTDN---QLTTL--PLAGLGGLMHLKLK 451

  Fly   551 -----------------------------------SAQRRNGDYLHVSTHCDDEEEDQ------- 573
                                               |..:.:|.:.....|.::||..:
Mouse   452 GNLALSQAFSKDSFPKLRILEVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEAPKRPLGLLA 516

  Fly   574 -QLHHH------PQQQPASQHHPHPNQQ-----------QHQQRKGS---------------QGH 605
             |..:|      ..|.......|||:.|           :|......               .|.
Mouse   517 GQAENHYDLDLDELQMGTEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGL 581

  Fly   606 VVSASGANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAA--ARLAGYAGHTWK-------T 661
            |:....|:..:||....|.:..:.........|..:.:.|||.  .:.|.| |..|:       |
Mouse   582 VLLTVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEY-GARWESGLGCQAT 645

  Fly   662 TPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEM----ATSVFCSEGQESDLFDSNY 722
            ..:|.  :.|..|..:.:.|....:...|....||..|:...    |.......|..:.|
Mouse   646 GFLAV--LGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAAL----- 703

  Fly   723 PDLLDIAKYAVA-----QAQQEGR--GQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPL 780
             .|..:.:|..:     .|..|||  ..|:|.|....| .||.    |..:|.|.:...|...
Mouse   704 -PLASVGEYGASPLCLPYAPPEGRPAALGFAVALVMMN-SLCF----LVVAGAYIKLYCDLPR-- 760

  Fly   781 LADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLVQSGAHQG 845
             .|..:.:..:.:...::|..|.||.....|..|:|  |....:....:...|.|.:|..
Mouse   761 -GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA--SMLGLFPVTPEAVKSVLLVVLP----- 817

  Fly   846 KLLPSHLGQKPSLPSSPVQH-----QRSLSSAATPLLDFSALASRAAGAANTSVAAYDYHAAQLE 905
              ||:.|.....|..:|  |     :|...|..:|    ..||..|||              :||
Mouse   818 --LPACLNPLLYLLFNP--HFRDDLRRLWPSPRSP----GPLAYAAAG--------------ELE 860

  Fly   906 RFLEEYRNLQDQLCKMKETCDTIRKKETPLRVAIGQSAAQLADPVMYSAASHSPKPPA--TSNLK 968
                            |.:||:.            |:....:|..:...||.:.:||.  |....
Mouse   861 ----------------KSSCDST------------QALVAFSDVDLILEASEAGQPPGLETYGFP 897

  Fly   969 TKTLLPGQPPDPPPYWLHRNAMLKRLNGDGSAGTNGSG-GSPASPQPRQDIFKS 1021
            :.||:....|.           ..||.|:....::|:. |:|..|...:.:.|:
Mouse   898 SVTLISRHQPG-----------ATRLEGNHFVESDGTKFGNPQPPMKGELLLKA 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	55/202 (27%)
		leucine-rich repeat	112..137	CDD:275380	12/70 (17%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	22/60 (37%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	9/22 (41%)
		LRRCT	267..316	CDD:214507	6/48 (13%)
		IG_like	328..428	CDD:214653	16/99 (16%)
		Ig	335..425	CDD:143165	14/89 (16%)
Lgr6	NP_001028581.1	LRRNT	34..68	CDD:214470	11/33 (33%)
		LRR_4	70..107	CDD:289563	7/36 (19%)
		leucine-rich repeat	70..91	CDD:275380	2/20 (10%)
		LRR 1	91..112		7/20 (35%)
		LRR_8	92..150	CDD:290566	12/57 (21%)
		LRR_4	92..131	CDD:289563	7/38 (18%)
		leucine-rich repeat	92..115	CDD:275380	7/22 (32%)
		LRR 2	115..136		1/20 (5%)
		leucine-rich repeat	116..139	CDD:275380	2/22 (9%)
		LRR_8	138..198	CDD:290566	18/59 (31%)
		LRR 3	139..160		5/20 (25%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		LRR_RI	143..392	CDD:238064	79/365 (22%)
		LRR 4	163..186		9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR_8	186..246	CDD:290566	22/60 (37%)
		LRR 5	187..208		8/20 (40%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		LRR 6	211..232		7/20 (35%)
		leucine-rich repeat	212..235	CDD:275380	9/23 (39%)
		LRR 7	235..256		8/21 (38%)
		leucine-rich repeat	236..258	CDD:275380	9/22 (41%)
		LRR_8	258..314	CDD:290566	16/106 (15%)
		LRR 8	258..279		6/38 (16%)
		leucine-rich repeat	259..282	CDD:275380	6/40 (15%)
		LRR 9	282..302		5/49 (10%)
		leucine-rich repeat	283..304	CDD:275380	5/50 (10%)
		LRR 10	303..325		7/39 (18%)
		LRR_8	305..364	CDD:290566	22/125 (18%)
		leucine-rich repeat	307..348	CDD:275380	15/103 (15%)
		LRR 11	329..350		10/69 (14%)
		LRR 12	353..374		6/20 (30%)
		leucine-rich repeat	354..375	CDD:275380	5/20 (25%)
		LRR_8	375..434	CDD:290566	13/66 (20%)
		LRR 13	375..396		3/20 (15%)
		leucine-rich repeat	376..399	CDD:275380	3/22 (14%)
		LRR 14	399..420		6/25 (24%)
		leucine-rich repeat	400..421	CDD:275380	5/25 (20%)
		LRR 15	423..443		7/24 (29%)
		leucine-rich repeat	424..444	CDD:275380	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840