DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lrrn4

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_796277.2	Gene:	Lrrn4 / 320974	MGIID:	2445154	Length:	733	Species:	Mus musculus

Alignment Length:	757	Identity:	165/757 - (21%)
Similarity:	249/757 - (32%)	Gaps:	250/757 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQ-----------LGQL----------RAECPAVCECKWKSGKESVLCLNANLT 102
            |.|||.||...||           |.:|          |....::|.....:|..::...|.:|.
Mouse    10 LQLLLQLLMAQSQSLERISQDRIPLFRLTQQGDWDSLDRHPTDSLCVGLPAAGVTTLNLANRSLE 74

  Fly   103 HIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFR-KLINLVELD 166
            .:|..|....:.||.|.|.::.:.:........|.:..::    |.|:...|..| .|..|.|||
Mouse    75 SLPSCLPRTLRSLDGSHNLLRALSEPVLGRLPELRVLTLH----HNRISVLHWGRDTLAELRELD 135

  Fly   167 LSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGL 231
            ||.|||:.:|..|....|.||.|.|:|||:..:....|...|.|..|.||...|.|||..||||:
Mouse   136 LSHNLLTELPPCAGPSGSSLRSLALAGNPLRALLPRTFACFPALRLLNLSCSELGHIAQEAFAGV 200

  Fly   232 E----SSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIP 292
            :    ::||.|.|.|..|..|.||.|.:|..|..|.|.:
Mouse   201 DGGPLAALELLDLSGTSLERVESGWIRNLPKLKSLFLRK-------------------------- 239

  Fly   293 PTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRL 357
                 .|||.     .|:.|.|...|.:...|              |
Mouse   240 -----MPRLK-----TLEGDIFKMTPNLRQLD--------------C------------------ 262

  Fly   358 IANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEA 422
                       .||...|:..|:        :.::..||.:|  ..|:..:      :..|...:
Mouse   263 -----------GDSPALTSVHTE--------IFQDTPNLQVL--QFQNCNL------SSFGPWNS 300

  Fly   423 SVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESY 487
            |..|:||                      |.|.   ..||.|.|
Mouse   301 SQVLSVS----------------------LFGN---PLICSCEL--------------------- 319

  Fly   488 EKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSA 552
                                      |.|..|..:....|||.|            :..|:.||.
Mouse   320 --------------------------AWLLVDVNKTVLHRAADT------------MCEPALGST 346

  Fly   553 QRRNG--DYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPH---PNQQQ----HQQRKGSQGHVVS 608
            ...:|  ...|:|..|..::....|..:|.:...|...|.   |:.:|    ..|..|||.::..
Mouse   347 GPFSGPLSLSHLSNVCRSDQSTTLLPSNPGRFDHSVFAPRIQGPSIEQSTALSAQPGGSQQNITK 411

  Fly   609 ASGANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAARL---AGYAGHTWKTTPI------ 664
            ......::|.:.:.::     .....::|.|:.|..|.:.:|.   |..:|.....|.|
Mouse   412 VPSLTMTSPTQGSWMY-----KDASEETAQSTNSELVYSPSRALPGAASSGAEQTATHILEPNIS 471

  Fly   665 -ATTKINSPHSKPV-TSAAPSSL-----NTQATPYAHYGNHPADEMATSVFCSEGQESDLFDSNY 722
             |:|.:.|.:.:|: ||..|.||     .|||||.|.:.:.|.||:...:...:.:|.:..|...
Mouse   472 SASTPLVSKYLEPLPTSPNPRSLPQTKQRTQATPRALHTDPPQDEIPVLLLDDDSEEEETRDQVA 536

  Fly   723 PDLLDIA-KY----------AVAQAQQEGRGQGYAQATTTPN 753
            ....|:: :|          |..|.:...|..|.:...|||:
Mouse   537 APPQDVSCEYHPCKHLQTPCAELQRRFRCRCPGLSGEDTTPD 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	57/161 (35%)
		leucine-rich repeat	112..137	CDD:275380	4/24 (17%)
		LRR_8	137..196	CDD:290566	23/59 (39%)
		leucine-rich repeat	138..161	CDD:275380	5/23 (22%)
		leucine-rich repeat	162..185	CDD:275380	11/22 (50%)
		LRR_8	184..245	CDD:290566	27/64 (42%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	12/27 (44%)
		leucine-rich repeat	235..258	CDD:275380	11/22 (50%)
		LRRCT	267..316	CDD:214507	6/48 (13%)
		IG_like	328..428	CDD:214653	12/99 (12%)
		Ig	335..425	CDD:143165	11/89 (12%)
Lrrn4	NP_796277.2	LRR 1	62..82		5/19 (26%)
		LRR	<63..292	CDD:227223	78/321 (24%)
		leucine-rich repeat	63..83	CDD:275380	4/19 (21%)
		LRR 2	83..106		4/22 (18%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		LRR 3	107..128		5/24 (21%)
		leucine-rich repeat	108..130	CDD:275380	6/25 (24%)
		LRR 4	130..151		11/20 (55%)
		leucine-rich repeat	131..154	CDD:275380	11/22 (50%)
		LRR 5	154..175		8/20 (40%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 6	178..199		10/20 (50%)
		leucine-rich repeat	179..207	CDD:275380	12/27 (44%)
		LRR 7	207..230		10/22 (45%)
		leucine-rich repeat	208..231	CDD:275380	11/22 (50%)
		LRR 8	231..253		9/57 (16%)
		leucine-rich repeat	232..256	CDD:275380	9/59 (15%)
		LRR 9	256..278		6/72 (8%)
		leucine-rich repeat	257..281	CDD:275380	6/74 (8%)
		LRR 10	281..302		5/28 (18%)
		leucine-rich repeat	303..315	CDD:275378	5/36 (14%)
		Herpes_TAF50	<347..541	CDD:308764	44/198 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..423		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..518		15/37 (41%)
		fn3	578..657	CDD:365830	0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4932
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050