DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lingo4

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_796224.1	Gene:	Lingo4 / 320747	MGIID:	2444651	Length:	618	Species:	Mus musculus

Alignment Length:	690	Identity:	160/690 - (23%)
Similarity:	219/690 - (31%)	Gaps:	251/690 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAGRAAATLEAPGP---PSGQDIASDNSAQRRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLL 63
            |..|.:|.|:|...   |.|.|.|:                         .|.:..||....|.|
Mouse     6 ALERCSAQLDATPQLLRPQGMDAAT-------------------------APKQAWLPWSPLLFL 45

  Fly    64 WLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSG--------- 119
            .||     .|...:.||.||:|  .|...:|.|.:..|..||..|...|:||||||
Mouse    46 LLL-----PGGSISSCPTVCDC--TSQTRAVFCAHRRLDTIPGGLPLDTELLDLSGNRLWGLQRG 103

  Fly   120 ---------------------------------------------------------------NE 121
                                                                           |:
Mouse   104 MLSRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLTALTLLDLRLNQ 168

  Fly   122 IQLIPDDSF----------------------ATAQLLNLQKVYLARCHLRLIERHAFRKL----- 159
            |.|..|.:|                      |.|.|..|..:.|.||:|..:...|..:|
Mouse   169 IVLFLDGAFSELGSLQQLEVGDNHLVFVAPGAFAGLAKLSTITLERCNLSTVPGLALAQLPALVA 233

  Fly   160 INLVELDLSQ----------------------------------NL---------LSAIPSLALY 181
            :.|.|||:.:                                  ||         ||::|..||:
Mouse   234 LRLRELDIERLPAGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALH 298

  Fly   182 HVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLS 246
            |:|.||.|.||.|||..:|......:.:|.:|.||...|:.||..||.|| ::...|.:..|.|.
Mouse   299 HLSFLRILDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGL-TAFHLLDVADNALQ 362

  Fly   247 EVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM--LQQNIPSGI-PPTCESPPRLSGRAW-- 306
            .:......|...|..|.|:.|...|.|.|    .|:  |::.:..|. ||.|..|..:.|::.
Mouse   363 TLEETAFPSPDKLVTLRLSGNPLTCDCRL----LWLLRLRRRLDFGTSPPACAGPQHVQGKSLRE 423

  Fly   307 --DKLDVDDFACVPQIVATDTTAHGV--EGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDG 367
              |.|....|.|.|.::........:  ||.:...||..:|.|.|.|.|:
Mouse   424 FSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWM--------------- 473

  Fly   368 DSDSEPRTAAATQGRKTYVVNMLR--NASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSR 430
                  |...|..||    |..:|  ....|.|.:..::|.|.|.|...|.||.......|.|.:
Mouse   474 ------RPQGAWLGR----VGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQ 528

  Fly   431 RPPEAPWGV----RIILLG----------AVAALLLVGGSSF-AAICLCSLQRRRKLRLWNSVPP 480
            ..|  |.|.    .|.:.|          .||.:|.||...| .::.||.    ..:.||:
Mouse   529 VEP--PNGTLSDPNITMPGIPGPFFLDSRGVAMVLAVGFLPFLTSVTLCF----GLIALWS---- 583

  Fly   481 VRRSESYEKIEMT---ARTRPDLGGGASCGGGSATGAGLF 517
              :.:...|..||   ...||   .|....||:...|.||
Mouse   584 --KGKGRVKHHMTFDFVAPRP---SGDKNSGGNRVTAKLF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	62/298 (21%)
		leucine-rich repeat	112..137	CDD:275380	15/118 (13%)
		LRR_8	137..196	CDD:290566	26/106 (25%)
		leucine-rich repeat	138..161	CDD:275380	7/27 (26%)
		leucine-rich repeat	162..185	CDD:275380	12/65 (18%)
		LRR_8	184..245	CDD:290566	23/60 (38%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	11/23 (48%)
		leucine-rich repeat	235..258	CDD:275380	4/22 (18%)
		LRRCT	267..316	CDD:214507	15/55 (27%)
		IG_like	328..428	CDD:214653	25/103 (24%)
		Ig	335..425	CDD:143165	22/91 (24%)
Lingo4	NP_796224.1	LRRNT	56..89	CDD:214470	13/34 (38%)
		leucine-rich repeat	69..86	CDD:275380	6/16 (38%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		LRR_8	90..145	CDD:290566	5/54 (9%)
		leucine-rich repeat	111..134	CDD:275380	0/22 (0%)
		LRR_RI	112..345	CDD:238064	44/232 (19%)
		LRR_8	134..193	CDD:290566	5/58 (9%)
		leucine-rich repeat	135..158	CDD:275380	0/22 (0%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		LRR_8	182..237	CDD:290566	10/54 (19%)
		leucine-rich repeat	183..206	CDD:275380	3/22 (14%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..302	CDD:275380	8/46 (17%)
		LRR_8	278..334	CDD:290566	21/55 (38%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		LRR_8	326..385	CDD:290566	19/59 (32%)
		leucine-rich repeat	327..350	CDD:275380	11/23 (48%)
		leucine-rich repeat	351..369	CDD:275380	3/17 (18%)
		leucine-rich repeat	375..387	CDD:275378	4/11 (36%)
		IG_like	445..526	CDD:214653	25/105 (24%)
		Ig	456..526	CDD:299845	23/94 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910