DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Amigo3

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_835280.1 Gene:Amigo3 / 316003 RGDID:631413 Length:508 Species:Rattus norvegicus


Alignment Length:481 Identity:132/481 - (27%)
Similarity:186/481 - (38%) Gaps:81/481 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LLLWLLCCCSQLGQLRAE-----------CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQL 114
            :||.||.|....|...::           ||..|.|    ..:.:.|....|..:|..|.|....
  Rat     5 VLLGLLLCMLGAGSGTSDLEGVLPPDPHNCPNKCVC----AADVLSCAGRGLQDLPAALPATAAE 65

  Fly   115 LDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLA 179
            ||||.|.::.:.....  |.|..|:.:||....|.::.|..|.....|..||||.|||..:.:..
  Rat    66 LDLSHNALKRLHPGWL--APLSRLRALYLGYNKLDVLGRGVFTNASGLRILDLSSNLLRRLRTYD 128

  Fly   180 LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLE-SSLEWLKLDGN 243
            |..:.||.:|.|..|.::.:..|||..:..|..|.||...||..:.....||. :.|..|.|..|
  Rat   129 LDGLEELEKLLLFNNRLMHLDLDAFQGLSMLSHLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSN 193

  Fly   244 RLSEVRSGTITSLASL-----HGLELARNTWNCSCSL-RPLRAWMLQQNIPSGIPP-----TC-- 295
            .|..|   ::..||:|     :.|.|..|...|.||| ..||.|  .|...|.:..     ||  
  Rat   194 WLGHV---SVPELAALPTFLKNRLYLHNNPLPCDCSLYHLLRRW--HQRGLSALHDFEREYTCLA 253

  Fly   296 ----ESPPRL--SGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLL- 353
                ||..|.  ..|.:....|   |..|.:...:...|...|:::.:.|... ||...|.|:. 
  Rat   254 FKVAESRVRFFEHSRVFKNCSV---AAAPGLELPEEELHTHVGQSLRLFCNTT-VPAARVAWVSP 314

  Fly   354 KNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAA----- 413
            ||.|   |.|.|..|..                :.:|.:.| |.|.....|.||::.|.|     
  Rat   315 KNEL---LVAPGSQDGS----------------IAVLADGS-LAIGRVQEQHAGLFVCLASGPRL 359

  Fly   414 -ENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAIC--LCSLQRRR-KLRL 474
             .|:.  :|.:|::...|..|||.......|||.:..|:||....||..|  .|...||. :.|.
  Rat   360 HHNQT--LEYNVSVHKPRPEPEAFNTGFTTLLGCIVGLVLVLLYLFAPPCRGCCRCCRRACRNRC 422

  Fly   475 W-NSVPPVRRSESYEKIEMTARTRPD 499
            | .:..|::...:...:..|  |.||
  Rat   423 WPRASSPLQELSAQSSVLST--TPPD 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 50/162 (31%)
leucine-rich repeat 112..137 CDD:275380 7/24 (29%)
LRR_8 137..196 CDD:290566 20/58 (34%)
leucine-rich repeat 138..161 CDD:275380 6/22 (27%)
leucine-rich repeat 162..185 CDD:275380 9/22 (41%)
LRR_8 184..245 CDD:290566 20/61 (33%)
leucine-rich repeat 186..209 CDD:275380 7/22 (32%)
leucine-rich repeat 210..234 CDD:275380 8/24 (33%)
leucine-rich repeat 235..258 CDD:275380 7/22 (32%)
LRRCT 267..316 CDD:214507 17/62 (27%)
IG_like 328..428 CDD:214653 26/106 (25%)
Ig 335..425 CDD:143165 23/96 (24%)
Amigo3NP_835280.1 LRR 1 62..83 5/22 (23%)
LRR_8 65..121 CDD:404697 19/57 (33%)
leucine-rich repeat 65..86 CDD:275380 7/22 (32%)
LRR 2 86..107 6/20 (30%)
leucine-rich repeat 87..110 CDD:275380 6/22 (27%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 8/20 (40%)
leucine-rich repeat 135..158 CDD:275380 7/22 (32%)
LRR_8 142..193 CDD:404697 15/50 (30%)
LRR 5 158..178 6/19 (32%)
leucine-rich repeat 159..184 CDD:275380 8/24 (33%)
LRR 6 184..207 8/25 (32%)
leucine-rich repeat 185..208 CDD:275380 9/25 (36%)
Ig_3 279..355 CDD:404760 23/96 (24%)
Ig strand B 295..303 CDD:409353 1/7 (14%)
Ig strand C 308..313 CDD:409353 2/4 (50%)
Ig strand C' 316..318 CDD:409353 1/1 (100%)
Ig strand D 329..332 CDD:409353 0/2 (0%)
Ig strand E 335..342 CDD:409353 3/7 (43%)
Ig strand F 348..355 CDD:409353 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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