DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lingo1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	119/534 - (22%)
Similarity:	170/534 - (31%)	Gaps:	189/534 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLW----LLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNE 121
            |..|    ||...|.|......||..|||  .:...:|||.......:|:.:...|:||||..|.
  Rat    20 LACWQPILLLVLGSVLSGSATGCPPRCEC--SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNR 82

  Fly   122 IQLIPDDSFAT----------------------AQLLNLQKVYLARCHLRLIERHAFRKLINLVE 164
            |:.:..|.||:                      ..|.||:.:.|....|:||....|..|.||.:
  Rat    83 IKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTK 147

  Fly   165 LDLSQNL---------------------------------------------------------- 171
            ||:|:|.
  Rat   148 LDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALS 212

  Fly   172 --------------------------------------------------------------LSA 174
                                                                          |:|
  Rat   213 HLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 277

  Fly   175 IPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLK 239
            :|.||:.|:..||.|.||.|||..:.......:.:|.:::|...:|:.:...||.|| :.|..|.
  Rat   278 VPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGL-NYLRVLN 341

  Fly   240 LDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPL--RAWMLQQNIPSGIPPTCESPPRLS 302
            :.||:|:.:......|:.:|..|.|..|...|.|.|..:  |.|.|..|...   |||.:|..:.
  Rat   342 VSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQ---PTCATPEFVQ 403

  Fly   303 GRAW----DKLDVDDFACVPQIVATDTTAHGV---EGRNITMSCYVEGVPQPAVKWLLKNRLIAN 360
            |:.:    |.|..:.|.| .:....|..|..|   ||..:...|..:|.|.||:.||
  Rat   404 GKEFKDFPDVLLPNYFTC-RRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWL-------- 459

  Fly   361 LSAGGDGDSDSEPR---TAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEA 422
                       .||   .:|.:.||.|...:     ..|.:..|.:||.|.|.|.|.|..|....
  Rat   460 -----------SPRKHLVSAKSNGRLTVFPD-----GTLEVRYAQVQDNGTYLCIAANAGGNDSM 508

  Fly   423 SVTLAVSRRPPEAP 436
            ...|.|....|:.|
  Rat   509 PAHLHVRSYSPDWP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	55/298 (18%)
		leucine-rich repeat	112..137	CDD:275380	11/46 (24%)
		LRR_8	137..196	CDD:290566	26/178 (15%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	11/142 (8%)
		LRR_8	184..245	CDD:290566	19/60 (32%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	16/54 (30%)
		IG_like	328..428	CDD:214653	27/105 (26%)
		Ig	335..425	CDD:143165	23/92 (25%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	10/35 (29%)
		LRR	<66..371	CDD:227223	57/305 (19%)
		leucine-rich repeat	73..96	CDD:275380	10/22 (45%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		LRR_8	120..179	CDD:404697	14/58 (24%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..192	CDD:275380	5/46 (11%)
		leucine-rich repeat	193..216	CDD:275380	0/22 (0%)
		leucine-rich repeat	217..264	CDD:275380	0/46 (0%)
		leucine-rich repeat	265..288	CDD:275380	6/22 (27%)
		leucine-rich repeat	289..312	CDD:275380	8/22 (36%)
		leucine-rich repeat	313..336	CDD:275380	7/23 (30%)
		leucine-rich repeat	337..357	CDD:275380	5/19 (26%)
		PCC	341..>421	CDD:188093	23/82 (28%)
		IgI_Lingo-1	423..514	CDD:409561	29/114 (25%)
		Ig strand B	442..446	CDD:409561	0/3 (0%)
		Ig strand C	455..459	CDD:409561	1/3 (33%)
		Ig strand E	480..484	CDD:409561	1/3 (33%)
		Ig strand F	494..499	CDD:409561	2/4 (50%)
		Ig strand G	507..510	CDD:409561	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910