DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lrig2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001101180.1	Gene:	Lrig2 / 310753	RGDID:	1309554	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	1176	Identity:	223/1176 - (18%)
Similarity:	349/1176 - (29%)	Gaps:	430/1176 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECK----------------- 86
            :|...||||...|.|..||.:.....||...:..|.    |||.|.|:
  Rat     6 RGVWEQRRLGCRLGPLAPLLMLAQALLLLPAAGAGL----CPAPCSCRLPLLDCSRRKLPALSWR 66

  Fly    87 ----------------------WKSGKES----VLCLNAN-LTHIP---QPLDAGTQL------- 114
                                  |....||    .:.:|.| ||.||   :|....|||
  Rat    67 ALSGPLSPDISSLDLSHNRLSNWNISLESETLQEVKMNYNELTEIPYFGEPTPNITQLSLVHNLI 131

  Fly   115 ----------------LDLSGNEIQLIPDDSFATAQL--LNLQ---------------------- 139
                            ||||.|.|..|...||....|  |||.
  Rat   132 PEINAEAFQLYSALESLDLSSNIISEIKTSSFPRMSLKYLNLSNNRITTLEAGCFDNLSGSLLVV 196

  Fly   140 ------------KVY---------LARCHLRLIE----------------RH--------AFRKL 159
                        ||:         |.|..::::|                |:        ||..|
  Rat   197 KLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGL 261

  Fly   160 INLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIA 224
            .|:.||:|..|.|:.:....||.:..|::|.:|.|.|.::..||:....:|..|:||..:|:.:.
  Rat   262 NNMEELELEHNNLTGVHKGWLYGLRMLQQLYVSQNAIEKISPDAWEFCQRLSALDLSYNQLTRLD 326

  Fly   225 VRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARN--TWN----------------- 270
            ..||.|| |.||.|.|..||::.:..|....|::|..|:|..|  :|.
  Rat   327 ESAFVGL-SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEVFSGLKSLTKL 390

  Fly   271 -------------------------------------------------------CSCSLRPLRA 280
                                                                   |.|.|:.|..
  Rat   391 ILQGNRIKSVTQKAFVGLESLEYLDLNNNAIMSIQENAFSQTHLKELVLNTSSLLCDCHLKWLLQ 455

  Fly   281 WMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC----VPQIVATDTTAHGVEGRNITMSC-Y 340
            |::..|....:..:|..|..|:|::...:|:.||.|    .|||.........:.|.|:|:.| .
  Rat   456 WLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPENTVALRGVNVTLMCTA 520

  Fly   341 VEGVPQP-AVKWLLKNRLIANLSAGG-------DGDSDSEPRTAAATQGRKTYVVNMLRNASNLT 397
            |.....| :..|...:.::.::....       ||::                    |...|.|.
  Rat   521 VSSSDSPMSTLWRKDSEILYDVDIENFVRYRQQDGEA--------------------LEYTSVLR 565

  Fly   398 ILTADMQDAGIYTCAAENKAG-KVEASVTLAVSRRPP--EAPWGVRIILLGAVAALLLV------ 453
            :.:.:..|.|.|.|...|..| .......|.|:..|.  :.|..: .|..||:|.|...
  Rat   566 LFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDL-TIRTGAMARLECAAEGHPT 629

  Fly   454 --------GGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASC---- 506
                    ||:.|.|      .|.|::.:   :|.       :.:...|..:.:..|..||
  Rat   630 PQISWQKDGGTDFPA------ARERRMHV---MPE-------DDVFFIANVKIEDMGIYSCMAQN 678

  Fly   507 -GGGSATGAGLFHDAEEQGYLRAAHTPLNDNDA--GQAAAIVNPSAGSAQRRNGDYLHVSTHCDD 568
             .||.:..|.| ...|...::|    ||.|...  |:.|.:...:.||..
  Rat   679 IAGGLSANASL-TVLETPSFIR----PLEDKTVTRGETAVLQCIAGGSPA--------------- 723

  Fly   569 EEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASG----------ANNSAPLEETDL 623
                      |:........|....::|.....:|..::..:|          .:|:...|...:
  Rat   724 ----------PRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHI 778

  Fly   624 HIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQ 688
            :: .:|.....||:.:||..:.|.           |.|..|....:       |.....:||...
  Rat   779 YL-NVISSPNCDSSQNSIGHEDDG-----------WTTVGIVIIVV-------VCCVVGTSLIWV 824

  Fly   689 ATPYAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPN 753
            ...| |......|...|:.          .:.|.|  .||..|..:|.......:||:.:....:
  Rat   825 IVIY-HMRRKDEDYSITNT----------EELNLP--ADIPSYLSSQGTLSEPQEGYSNSEAGSH 876

  Fly   754 GGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANY 818
            ..|      :..:..|....:|..:......|..|.::.:               ||....|..|
  Rat   877 QQL------MPPASGYTHKGTDGGTGTRVICSDCYDNANI---------------YSRTREYCPY 920

  Fly   819 SSTATYTGGGQRANSFL----------NLVQSGAHQGKLLPSHLGQKPSLPSSPVQHQRS----- 868
            :..|......|..:|.:          :..|..|:...|:|.   .:..|.:.|..|:|:
  Rat   921 TYIAEEDALDQALSSLMVQMPKETFLSHPPQDAANLESLMPP---TERELSAFPTNHERTSENLP 982

  Fly   869 ----------------------LSSAATPLLDFSALASRAAGAAN-TSVAAYDYHAAQLERFLEE 910
                                  |.....|:|:...||.|....:: .|......||....|
  Rat   983 FSQRSSEIFQRPLWNMNRDLGLLPFPQQPVLESPQLAERDPNCSSPVSCHRLHDHAFDFSR---- 1043

  Fly   911 YRNLQD 916
            .||:||
  Rat  1044 TRNIQD 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	61/248 (25%)
		leucine-rich repeat	112..137	CDD:275380	13/49 (27%)
		LRR_8	137..196	CDD:290566	23/125 (18%)
		leucine-rich repeat	138..161	CDD:275380	10/89 (11%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	22/60 (37%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	15/122 (12%)
		IG_like	328..428	CDD:214653	19/109 (17%)
		Ig	335..425	CDD:143165	16/99 (16%)
Lrig2	NP_001101180.1	LRR_RI	<50..204	CDD:238064	26/153 (17%)
		leucine-rich repeat	98..120	CDD:275380	7/21 (33%)
		LRR_8	119..178	CDD:290566	16/58 (28%)
		leucine-rich repeat	121..144	CDD:275380	3/22 (14%)
		LRR_RI	136..398	CDD:238064	60/262 (23%)
		leucine-rich repeat	145..167	CDD:275380	9/21 (43%)
		LRR_8	167..226	CDD:290566	8/58 (14%)
		leucine-rich repeat	168..192	CDD:275380	4/23 (17%)
		leucine-rich repeat	193..215	CDD:275380	2/21 (10%)
		leucine-rich repeat	216..239	CDD:275380	3/22 (14%)
		LRR_8	239..298	CDD:290566	16/58 (28%)
		leucine-rich repeat	240..263	CDD:275380	4/22 (18%)
		leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..311	CDD:275380	7/22 (32%)
		LRR_8	311..370	CDD:290566	22/59 (37%)
		leucine-rich repeat	312..335	CDD:275380	9/23 (39%)
		leucine-rich repeat	336..359	CDD:275380	8/22 (36%)
		LRR_8	358..421	CDD:290566	5/62 (8%)
		leucine-rich repeat	360..384	CDD:275380	5/23 (22%)
		LRR_4	385..426	CDD:289563	0/40 (0%)
		leucine-rich repeat	387..410	CDD:275380	0/22 (0%)
		leucine-rich repeat	411..433	CDD:275380	0/21 (0%)
		LRRCT	444..492	CDD:214507	13/47 (28%)
		Ig	501..597	CDD:299845	19/115 (17%)
		IG	503..597	CDD:214652	19/113 (17%)
		I-set	601..691	CDD:254352	22/107 (21%)
		Ig_1	618..692	CDD:143240	17/90 (19%)
		I-set	695..782	CDD:254352	15/116 (13%)
		Ig	713..782	CDD:299845	9/94 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840