DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lrrc4b

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001258010.1	Gene:	Lrrc4b / 308571	RGDID:	1307121	Length:	709	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	188/802 - (23%)
Similarity:	263/802 - (32%)	Gaps:	287/802 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LHPPLRPRLPLHLHLLLWLLCCCSQLGQLRA-------------------ECPAVCECKWKSGKE 92
            |.||.|...|....|||||..     ..|||                   .|||.|.|..::.:
  Rat    13 LLPPGRMSWPQGALLLLWLFS-----PPLRAGGGGVAVTSAAGGGSPPATSCPAACSCSNQASR- 71

  Fly    93 SVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFR 157
             |:|....|..:|..:...|:.|:|..|.||:|..|:|  ..|.:|:.:.|::..:|.||..||.
  Rat    72 -VICTRRELAEVPASIPVNTRYLNLQENSIQVIRTDTF--KHLRHLEILQLSKNLVRKIEVGAFN 133

  Fly   158 KLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDC-RLS 221
            .|.:|..|:|..|.|:.:|:.|..::|:||||.|..|||..:|..||..||.|.:|:|.:. ||.
  Rat   134 GLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLE 198

  Fly   222 HIAVRAFAGLES---------------------SLEWLKLDGNRLSEVRSGTITSLAS------- 258
            :|:..||.||.:                     .||.|:|.||||..:|.|:...|.|
  Rat   199 YISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLM 263

  Fly   259 --------------------------------------LHGLE---LARNTWNCSCSLRPLRAWM 282
                                                  ||.||   |..|.|:|:|.:..| :|.
  Rat   264 HAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWL-SWW 327

  Fly   283 LQQNIPSGIP--PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGV 344
            |::.:||...  ..|.:|..|.||...:||...|.| .|.||...|..:..||....:.|.. |.
  Rat   328 LKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GT 391

  Fly   345 PQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNAS-NLTILTADMQDAGI 408
            ...:|.||                   .|.....|.|.....:::|.:.: |.|.:|  :||.|.
  Rat   392 SMTSVNWL-------------------TPNGTLMTHGSYRVRISVLHDGTLNFTNVT--VQDTGQ 435

  Fly   409 YTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLR 473
            |||...|.||...||.||.||...|             |||    ||.
  Rat   436 YTCMVTNSAGNTTASATLNVSAVDP-------------VAA----GGP----------------- 466

  Fly   474 LWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDA 538
                                       |||...|||.|.|||.:      .|.........:...
  Rat   467 ---------------------------GGGGPGGGGGAGGAGGY------TYFTTVTVETLETQP 498

  Fly   539 GQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQ 603
            |:.|                                      |||.......|.........|.:
  Rat   499 GEEA--------------------------------------QQPRGTEKEPPGPTTDGAWGGGR 525

  Fly   604 GHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVD------------------AAAR 650
            ....:.:.|:.:||...:.....:...:..||...:::....|                  ||..
  Rat   526 PDAAAPASASTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVM 590

  Fly   651 LAGY------------AGHTWKTTPIATTKINSPHSKPVTSAAPSS------------------- 684
            |..:            .|.| :|..|...:...|.:..|:.||.::
  Rat   591 LVAFYKLRKQHQLHKHHGPT-RTVEIINVEDELPAASAVSVAAAAAVAGGAGVGGDSHLALPALE 654

  Fly   685 ---LN----TQATPYAHYGNHP 699
               ||    ..|...||||.:|
  Rat   655 RDHLNHHHYVAAAFKAHYGGNP 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	66/226 (29%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	22/58 (38%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	30/82 (37%)
		leucine-rich repeat	186..209	CDD:275380	12/22 (55%)
		leucine-rich repeat	210..234	CDD:275380	10/45 (22%)
		leucine-rich repeat	235..258	CDD:275380	11/22 (50%)
		LRRCT	267..316	CDD:214507	17/50 (34%)
		IG_like	328..428	CDD:214653	27/100 (27%)
		Ig	335..425	CDD:143165	23/90 (26%)
Lrrc4b	NP_001258010.1	LRRNT	59..92	CDD:214470	10/34 (29%)
		LRR	<89..299	CDD:227223	61/211 (29%)
		LRR 1	89..110		9/22 (41%)
		leucine-rich repeat	90..113	CDD:275380	10/24 (42%)
		LRR 2	113..134		7/20 (35%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR 3	137..158		7/20 (35%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		LRR 4	161..182		11/20 (55%)
		leucine-rich repeat	162..185	CDD:275380	12/22 (55%)
		LRR 5	185..207		8/21 (38%)
		leucine-rich repeat	186..210	CDD:275380	10/23 (43%)
		LRR 6	210..231		0/20 (0%)
		leucine-rich repeat	211..232	CDD:275380	0/20 (0%)
		LRR 7	232..253		10/20 (50%)
		leucine-rich repeat	233..256	CDD:275380	11/22 (50%)
		LRR 8	256..277		1/20 (5%)
		leucine-rich repeat	257..280	CDD:275380	0/22 (0%)
		LRR 9	280..301		0/20 (0%)
		leucine-rich repeat	281..302	CDD:275380	0/20 (0%)
		LRRCT	313..363	CDD:214507	17/50 (34%)
		I-set	366..455	CDD:400151	31/110 (28%)
		Ig strand A	366..369	CDD:409353	1/2 (50%)
		Ig strand A'	373..376	CDD:409353	1/2 (50%)
		Ig strand B	382..389	CDD:409353	1/6 (17%)
		Ig strand C	395..400	CDD:409353	3/23 (13%)
		Ig strand C'	403..405	CDD:409353	0/1 (0%)
		Ig strand D	414..418	CDD:409353	0/3 (0%)
		Ig strand E	421..425	CDD:409353	0/3 (0%)
		Ig strand F	435..442	CDD:409353	3/6 (50%)
		Ig strand G	445..455	CDD:409353	5/9 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..552		10/93 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810