DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lgi2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001100689.2	Gene:	Lgi2 / 305417	RGDID:	1310391	Length:	542	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	71/301 - (23%)
Similarity:	112/301 - (37%)	Gaps:	75/301 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQLGQLR--AECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQ 123
            |||...|......|:|  |.|||.|.|.    |||::|:.:  :.:|                 :
  Rat    13 LLLSAACLIPPSAQVRRLARCPATCSCT----KESIICVGS--SWVP-----------------R 54

  Fly   124 LIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRE 188
            ::|.|..:.:                         |:|...|::...:.|.:|||.|
  Rat    55 IVPGDISSLS-------------------------LVNGTFLEIKDRMFSHLPSLQL-------- 86

  Fly   189 LRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTI 253
            |.|:.|....:.||||..:..|..|.:...::..|:..||.||. .|..|.|..|.:..:.....
  Rat    87 LLLNSNSFTVIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLR-DLTHLSLANNHIKALPRDVF 150

  Fly   254 TSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPT-CESPPRLSGRAWDKLDVDDFACV 317
            :.|.||..|:|..|.:.|.|..:.|..|:...|  |.:... |..||....:..:.:...|:.|
  Rat   151 SDLDSLIELDLRGNKFECDCKAKWLYLWLKMTN--STVSDVLCIGPPEYQEKKLNDVTSFDYEC- 212

  Fly   318 PQIVATDTTAH--------GVEGRNITMSCYVEGVPQPAVK 350
               ..||...|        .|:..|.....|| .:.||:::
  Rat   213 ---TTTDFVVHQTLPYQSVSVDTFNSKNDVYV-AIAQPSME 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	33/156 (21%)
		leucine-rich repeat	112..137	CDD:275380	2/24 (8%)
		LRR_8	137..196	CDD:290566	11/58 (19%)
		leucine-rich repeat	138..161	CDD:275380	1/22 (5%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	18/60 (30%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	11/49 (22%)
		IG_like	328..428	CDD:214653	7/31 (23%)
		Ig	335..425	CDD:143165	4/16 (25%)
Lgi2	NP_001100689.2	LRR_8	107..166	CDD:404697	17/59 (29%)
		leucine-rich repeat	108..131	CDD:275378	7/23 (30%)
		leucine-rich repeat	132..155	CDD:275378	5/22 (23%)
		PCC	137..>212	CDD:188093	18/76 (24%)
		leucine-rich repeat	156..168	CDD:275378	4/11 (36%)
		EPTP	216..255	CDD:397689	8/35 (23%)
		EPTP	263..301	CDD:397689
		EPTP	308..352	CDD:397689
		EPTP	404..444	CDD:397689
		EPTP	449..488	CDD:397689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840