DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and Lgr5

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001100254.1 Gene:Lgr5 / 299802 RGDID:1307733 Length:907 Species:Rattus norvegicus


Alignment Length:257 Identity:80/257 - (31%)
Similarity:115/257 - (44%) Gaps:25/257 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 RPRLPLHLHLLLWLLCCCS--QLGQLRAECPAVCECKWKSGKE--SVLCLNANLTHIPQPLDAGT 112
            |.|:.|.|..||.|:...|  :...:...||:.|.|: ..|:.  .|.|.:..|:.:|..|...|
  Rat     5 RVRMLLSLLALLQLVAAGSPPRPDTMPRGCPSYCHCE-LDGRMLLRVDCSDLGLSELPSNLSVFT 68

  Fly   113 QLLDLSGNEIQLIPDDSFATAQLLN----LQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLS 173
            ..||||.|.|..:|      |.||:    |:::.||...|..|.:.||..|.:|..|.|..|.|.
  Rat    69 SYLDLSMNNISQLP------ASLLHRLRFLEELRLAGNALTHIPKGAFAGLHSLKVLMLQNNQLR 127

  Fly   174 AIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWL 238
            .:|..||.::..|:.|||..|.|..||...|..:..|..|.|.|..|:.:.|:||..| |:|:.:
  Rat   128 QVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSL-SALQAM 191

  Fly   239 KLDGNRLSEVRSGTITSLASLHGLELARNTWN-----CSCSLRPLRAWMLQQN----IPSGI 291
            .|..|::..:......:|:||..|.|..|..:     |...|..|....|..|    .|:.|
  Rat   192 TLALNKIHHIADHAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAI 253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 54/160 (34%)
leucine-rich repeat 112..137 CDD:275380 10/24 (42%)
LRR_8 137..196 CDD:290566 21/62 (34%)
leucine-rich repeat 138..161 CDD:275380 8/22 (36%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 22/60 (37%)
leucine-rich repeat 186..209 CDD:275380 9/22 (41%)
leucine-rich repeat 210..234 CDD:275380 9/23 (39%)
leucine-rich repeat 235..258 CDD:275380 4/22 (18%)
LRRCT 267..316 CDD:214507 8/34 (24%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
Lgr5NP_001100254.1 LRRNT 33..70 CDD:214470 11/37 (30%)
LRR 1 44..64 5/19 (26%)
LRR 2 65..88 11/28 (39%)
leucine-rich repeat 68..91 CDD:275380 11/28 (39%)
LRR_RI 88..372 CDD:238064 51/167 (31%)
LRR 3 89..112 7/22 (32%)
LRR_8 92..150 CDD:290566 21/57 (37%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
LRR 4 114..136 8/21 (38%)
leucine-rich repeat 116..139 CDD:275380 8/22 (36%)
LRR 5 137..160 9/22 (41%)
LRR_8 138..198 CDD:290566 22/60 (37%)
leucine-rich repeat 140..163 CDD:275380 9/22 (41%)
LRR 6 162..184 8/21 (38%)
leucine-rich repeat 164..187 CDD:275380 9/23 (39%)
LRR 7 186..208 4/21 (19%)
LRR_8 188..246 CDD:290566 14/57 (25%)
leucine-rich repeat 188..211 CDD:275380 4/22 (18%)
LRR 8 209..232 7/22 (32%)
leucine-rich repeat 212..235 CDD:275380 6/22 (27%)
LRR 9 233..256 6/21 (29%)
leucine-rich repeat 236..258 CDD:275380 5/18 (28%)
LRR_8 257..314 CDD:290566
LRR 10 257..279
leucine-rich repeat 259..282 CDD:275380
LRR 11 281..303
leucine-rich repeat 283..304 CDD:275380
LRR 12 304..327
leucine-rich repeat 307..353 CDD:275380
LRR 13 328..350
LRR 14 351..375
LRR_8 352..410 CDD:290566
leucine-rich repeat 354..375 CDD:275380
leucine-rich repeat 376..399 CDD:275380
LRR 15 377..396
LRR 16 397..420
leucine-rich repeat 400..423 CDD:275380
LRR 17 422..444
leucine-rich repeat 445..467 CDD:275378
LRR 18 564..585
7tm_1 575..820 CDD:278431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335009
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.