DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lrrc52

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001070902.1	Gene:	Lrrc52 / 289199	RGDID:	1312014	Length:	314	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	76/316 - (24%)
Similarity:	118/316 - (37%)	Gaps:	65/316 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 AECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKV 141
            ::||..|.|:    .:.|.|.:..||..|..:...|:.|.|:.|:|..:|     ..||..|..:
  Rat    24 SKCPNNCLCQ----DQEVACTDLQLTEYPTDIPLNTRRLYLNNNKITSLP-----ALQLGFLSDL 79

  Fly   142 YLARC---HLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDA 203
            ....|   .:|.:..:.|..:..|:.||||.|.|::|...:...::.|..|.:|.||
  Rat    80 VYLDCQNNRIREVMDYTFIGIFKLLYLDLSSNNLTSISPFSFSILTNLVRLNISNNP-------- 136

  Fly   204 FGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNT 268
              |:..|.|.             .||. .:||.:|.|....:..:.......|..|..|.|:.|.
  Rat   137 --HLLYLDKY-------------IFAN-TTSLRYLDLRNTGMQIIDHTGFHHLVVLQTLYLSGNP 185

  Fly   269 WNCSCSLRPLRAWMLQQNI--PSGIPPTCESPPRLSGRAWDKLDVDD---FACVPQIVATD---- 324
            |.|:||.......:|..::  |.....||..||.|.|  |....|.:   :.|:..:...|
  Rat   186 WKCNCSFLDFTIHLLVSHMDHPDAQNATCTEPPELKG--WPITKVGNPLQYMCITHLDHQDYIFL 248

  Fly   325 ------TTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPR 374
                  ..|.|.....:|..|.|          |.:|.|  ..|:|.|.:.::..|
  Rat   249 LLIGFCIFAAGTVAAWLTGVCAV----------LYQNAL--RKSSGDDTEDETGNR 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	38/159 (24%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	16/61 (26%)
		leucine-rich repeat	138..161	CDD:275380	4/25 (16%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	14/60 (23%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	4/23 (17%)
		leucine-rich repeat	235..258	CDD:275380	4/22 (18%)
		LRRCT	267..316	CDD:214507	15/53 (28%)
		IG_like	328..428	CDD:214653	11/47 (23%)
		Ig	335..425	CDD:143165	10/40 (25%)
Lrrc52	NP_001070902.1	LRRNT	26..55	CDD:214470	9/32 (28%)
		leucine-rich repeat	35..54	CDD:275380	5/18 (28%)
		LRR_4	56..92	CDD:289563	10/40 (25%)
		leucine-rich repeat	56..78	CDD:275380	8/26 (31%)
		LRR_8	79..136	CDD:290566	14/56 (25%)
		leucine-rich repeat	79..102	CDD:275380	3/22 (14%)
		LRR_4	102..>136	CDD:289563	11/33 (33%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR_8	125..185	CDD:290566	18/83 (22%)
		leucine-rich repeat	127..151	CDD:275380	10/47 (21%)
		leucine-rich repeat	152..175	CDD:275380	4/22 (18%)
		TPKR_C2	184..>222	CDD:301599	12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334986
Domainoid	1	1.000	41	1.000	Domainoid score	I12167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930