DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Lgr4

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_775450.2 Gene:Lgr4 / 286994 RGDID:628615 Length:951 Species:Rattus norvegicus


Alignment Length:256 Identity:85/256 - (33%)
Similarity:117/256 - (45%) Gaps:15/256 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 LPLHLHLL----LWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLL 115
            :|..|.||    |.||......|.....|.|.|.|   .|...|.|....||.:|:.|.|.||.|
  Rat     1 MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSC---DGDRRVDCSGKGLTAVPEGLSAFTQAL 62

  Fly   116 DLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLAL 180
            |:|.|.|..:|:|:|.:...  |:::.||...|..|...|...|..|..|.|..|.|..:||.|:
  Rat    63 DISMNNITQLPEDAFKSFPF--LEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLRTVPSEAI 125

  Fly   181 YHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRL 245
            :.:|.|:.|||..|.|..||:|:|..:.||..|.|.|..|:.:.||..:.| .:|:.|.|..|.:
  Rat   126 HGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVRPLSNL-PTLQALTLALNNI 189

  Fly   246 SEVRSGTITSLASLHGLELARN-----TWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRL 301
            |.:.....|:|:||..|.|..|     :.:|...|..|....|..|.....|...::.|.|
  Rat   190 SSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSL 250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 57/156 (37%)
leucine-rich repeat 112..137 CDD:275380 10/24 (42%)
LRR_8 137..196 CDD:290566 21/58 (36%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 24/60 (40%)
leucine-rich repeat 186..209 CDD:275380 10/22 (45%)
leucine-rich repeat 210..234 CDD:275380 8/23 (35%)
leucine-rich repeat 235..258 CDD:275380 7/22 (32%)
LRRCT 267..316 CDD:214507 9/40 (23%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
Lgr4NP_775450.2 LRRNT 29..61 CDD:214470 13/34 (38%)
LRR 1 58..79 10/20 (50%)
leucine-rich repeat 59..82 CDD:275380 10/22 (45%)
LRR <62..301 CDD:227223 63/192 (33%)
LRR 2 82..103 6/22 (27%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
LRR 3 106..127 8/20 (40%)
leucine-rich repeat 107..130 CDD:275380 8/22 (36%)
LRR 4 130..151 10/20 (50%)
leucine-rich repeat 131..154 CDD:275380 10/22 (45%)
LRR 5 154..177 9/23 (39%)
leucine-rich repeat 155..178 CDD:275380 8/23 (35%)
LRR 6 178..199 5/20 (25%)
leucine-rich repeat 179..202 CDD:275380 7/22 (32%)
LRR 7 202..223 6/20 (30%)
leucine-rich repeat 203..226 CDD:275380 6/22 (27%)
LRR 8 226..247 4/20 (20%)
leucine-rich repeat 227..249 CDD:275380 4/21 (19%)
LRR 9 249..270 1/2 (50%)
leucine-rich repeat 250..273 CDD:275380 1/1 (100%)
LRR 10 273..294
leucine-rich repeat 274..295 CDD:275380
LRR 275..>465 CDD:227223
LRR 11 320..341
leucine-rich repeat 321..344 CDD:275378
LRR 12 344..365
LRR_8 345..401 CDD:404697
leucine-rich repeat 345..366 CDD:275378
LRR 13 366..387
leucine-rich repeat 367..390 CDD:275378
LRR 14 390..411
leucine-rich repeat 391..414 CDD:275378
LRR 15 414..435
leucine-rich repeat 415..427 CDD:275378
leucine-rich repeat 436..461 CDD:275380
7tmA_LGR4 539..812 CDD:320483
TM helix 1 541..565 CDD:320483
TM helix 2 574..595 CDD:320483
TM helix 3 619..641 CDD:320483
TM helix 4 664..680 CDD:320483
TM helix 5 704..727 CDD:320483
TM helix 6 746..768 CDD:320483
TM helix 7 780..805 CDD:320483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334990
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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