DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Lrrc4b

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_937893.1 Gene:Lrrc4b / 272381 MGIID:3027390 Length:709 Species:Mus musculus


Alignment Length:811 Identity:191/811 - (23%)
Similarity:266/811 - (32%) Gaps:290/811 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 RKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRA-------------------ECPAVC 83
            |..|.|   |.||.|...|....|||||..     ..|||                   .|||.|
Mouse     7 RGSPCP---LLPPGRMSWPHGALLLLWLFS-----PPLRAGGGGVAVTSAAGGGSPPATSCPAAC 63

  Fly    84 ECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHL 148
            .|..::.:  |:|....|..:|..:...|:.|:|..|.||:|..|:|  ..|.:|:.:.|::..:
Mouse    64 SCSNQASR--VICTRRELAEVPASIPVNTRYLNLQENSIQVIRTDTF--KHLRHLEILQLSKNLV 124

  Fly   149 RLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKL 213
            |.||..||..|.:|..|:|..|.|:.:|:.|..::|:||||.|..|||..:|..||..||.|.:|
Mouse   125 RKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRL 189

  Fly   214 ELSDC-RLSHIAVRAFAGLES---------------------SLEWLKLDGNRLSEVRSGTITSL 256
            :|.:. ||.:|:..||.||.:                     .||.|:|.||||..:|.|:...|
Mouse   190 DLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGL 254

  Fly   257 AS---------------------------------------------LHGLE---LARNTWNCSC 273
            .|                                             ||.||   |..|.|:|:|
Mouse   255 TSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNC 319

  Fly   274 SLRPLRAWMLQQNIPSGIP--PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNI 335
            .:..| :|.|::.:||...  ..|.:|..|.||...:||...|.| .|.||...|..:..||...
Mouse   320 DVLWL-SWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAA 383

  Fly   336 TMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNAS-NLTIL 399
            .:.|.. |....:|.||                   .|.....|.|.....:::|.:.: |.|.:
Mouse   384 ELKCRT-GTSMTSVNWL-------------------TPNGTLMTHGSYRVRISVLHDGTLNFTNV 428

  Fly   400 TADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLC 464
            |  :||.|.|||...|.||...||.||.||...|             |||    ||.        
Mouse   429 T--VQDTGQYTCMVTNSAGNTTASATLNVSAVDP-------------VAA----GGP-------- 466

  Fly   465 SLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAA 529
                                                |||...|||.|.|||.:      .|....
Mouse   467 ------------------------------------GGGGPGGGGGAGGAGGY------TYFTTV 489

  Fly   530 HTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQ 594
            .....:...|:.|                                      |||.......|...
Mouse   490 TVETLETQPGEEA--------------------------------------QQPRGTEKEPPGPT 516

  Fly   595 QHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVD------------- 646
            ......|.:....:.:.|:.:||...:.....:...:..||...:::....|             
Mouse   517 TDGAWGGGRPDAAAPASASTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFV 581

  Fly   647 -----AAARLAGY------------AGHTWKTTPIATTKINSPHSKPVTSAAPSS---------- 684
                 ||..|..:            .|.| :|..|...:...|.:..|:.||.::          
Mouse   582 AITFMAAVMLVAFYKLRKQHQLHKHHGPT-RTVEIINVEDELPAASAVSVAAAAAVAGGAGVGGD 645

  Fly   685 ------------LN----TQATPYAHYGNHP 699
                        ||    ..|...||||.:|
Mouse   646 SHLALPALERDHLNHHHYVAAAFKAHYGGNP 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 66/226 (29%)
leucine-rich repeat 112..137 CDD:275380 10/24 (42%)
LRR_8 137..196 CDD:290566 22/58 (38%)
leucine-rich repeat 138..161 CDD:275380 8/22 (36%)
leucine-rich repeat 162..185 CDD:275380 7/22 (32%)
LRR_8 184..245 CDD:290566 30/82 (37%)
leucine-rich repeat 186..209 CDD:275380 12/22 (55%)
leucine-rich repeat 210..234 CDD:275380 10/45 (22%)
leucine-rich repeat 235..258 CDD:275380 11/22 (50%)
LRRCT 267..316 CDD:214507 17/50 (34%)
IG_like 328..428 CDD:214653 27/100 (27%)
Ig 335..425 CDD:143165 23/90 (26%)
Lrrc4bNP_937893.1 LRRNT 59..92 CDD:214470 10/34 (29%)
LRR <89..299 CDD:227223 61/211 (29%)
LRR 1 89..110 9/22 (41%)
leucine-rich repeat 90..113 CDD:275380 10/24 (42%)
LRR 2 113..134 7/20 (35%)
leucine-rich repeat 114..137 CDD:275380 8/22 (36%)
LRR 3 137..158 7/20 (35%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
LRR 4 161..182 11/20 (55%)
leucine-rich repeat 162..185 CDD:275380 12/22 (55%)
LRR 5 185..207 8/21 (38%)
leucine-rich repeat 186..210 CDD:275380 10/23 (43%)
LRR 6 210..231 0/20 (0%)
leucine-rich repeat 211..232 CDD:275380 0/20 (0%)
LRR 7 232..253 10/20 (50%)
leucine-rich repeat 233..256 CDD:275380 11/22 (50%)
LRR 8 256..277 1/20 (5%)
leucine-rich repeat 257..280 CDD:275380 0/22 (0%)
LRR 9 280..301 0/20 (0%)
leucine-rich repeat 281..302 CDD:275380 0/20 (0%)
LRRCT 313..363 CDD:214507 17/50 (34%)
I-set 366..455 CDD:400151 31/110 (28%)
Ig strand A 366..369 CDD:409353 1/2 (50%)
Ig strand A' 373..376 CDD:409353 1/2 (50%)
Ig strand B 382..389 CDD:409353 1/6 (17%)
Ig strand C 395..400 CDD:409353 3/23 (13%)
Ig strand C' 403..405 CDD:409353 0/1 (0%)
Ig strand D 414..418 CDD:409353 0/3 (0%)
Ig strand E 421..425 CDD:409353 0/3 (0%)
Ig strand F 435..442 CDD:409353 3/6 (50%)
Ig strand G 445..455 CDD:409353 5/9 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..552 10/93 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 1 0.900 - - OOG6_104601
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5308
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.840

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