DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and Islr

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:XP_006511267.1 Gene:Islr / 26968 MGIID:1349645 Length:436 Species:Mus musculus


Alignment Length:383 Identity:107/383 - (27%)
Similarity:169/383 - (44%) Gaps:57/383 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 LWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPD 127
            |.|||....|..:|| ||..|:|..|.|.:...|...:|..:|....|....|.||.|.:..:|:
Mouse    12 LCLLCWAVLLNLVRA-CPEPCDCGEKYGFQIADCAYRDLEGVPPGFPANVTTLSLSANRLPGLPE 75

  Fly   128 DSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLS 192
            .:|....|  ||.::||...:|.:...|...|.:|..||||.||||......|:::|.|:.|::.
Mouse    76 GAFREVPL--LQSLWLAHNEIRSVAIGALAPLSHLKSLDLSHNLLSEFAWSDLHNLSALQLLKMD 138

  Fly   193 GNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLA 257
            .|.:..:|.|||..:                         |:|..|:|:.|||..:..||...|.
Mouse   139 SNELAFIPRDAFSSL-------------------------SALRSLQLNHNRLHALAEGTFAPLT 178

  Fly   258 SLHGLELARNTWNCSCSLRPLRAWMLQQ--NIPSGIPPTCESPPRLSGRAWDKLDVDDFAC-VPQ 319
            :|..|::..|.::|:|.:...:.|.|..  :||......|.:|..|.|....:|  ....| .|.
Mouse   179 ALSHLQINDNPFDCTCGIVWFKTWALASAVSIPEQDNIACTTPHVLKGIPLGRL--PPLPCSAPS 241

  Fly   320 I-VATDTTAHGVE---GRNITMSCYVEGVPQPAVKWLLKNR----LIANLSAGGDGDSDSEPRT- 375
            : ::...:..|.|   |..:.:.|.|:|.|.|.:.|.:...    .||:.:.|.||      |. 
Mouse   242 VQLSYQPSQDGAELRPGFVLALHCDVDGQPVPQLHWHIHTPGGTVEIASPNVGTDG------RAL 300

  Fly   376 --AAATQGRKTYVVNMLRNASNLTILTADM--QDAGIYTCAAENKAGKVEASVTLAVS 429
              |.||.|:..:     :..:|.::|..|.  .:.|.|:|.|.|:.|..|:||.:|::
Mouse   301 PGALATSGQPRF-----QAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVNVALA 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 45/156 (29%)
leucine-rich repeat 112..137 CDD:275380 7/24 (29%)
LRR_8 137..196 CDD:290566 21/58 (36%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
leucine-rich repeat 162..185 CDD:275380 10/22 (45%)
LRR_8 184..245 CDD:290566 13/60 (22%)
leucine-rich repeat 186..209 CDD:275380 7/22 (32%)
leucine-rich repeat 210..234 CDD:275380 0/23 (0%)
leucine-rich repeat 235..258 CDD:275380 9/22 (41%)
LRRCT 267..316 CDD:214507 12/50 (24%)
IG_like 328..428 CDD:214653 31/111 (28%)
Ig 335..425 CDD:143165 27/98 (28%)
IslrXP_006511267.1 leucine-rich repeat 40..59 CDD:275380 3/18 (17%)
LRR_8 59..118 CDD:338972 20/60 (33%)
leucine-rich repeat 60..83 CDD:275380 6/22 (27%)
leucine-rich repeat 84..107 CDD:275380 7/22 (32%)
LRR_8 107..166 CDD:338972 23/83 (28%)
leucine-rich repeat 108..131 CDD:275380 10/22 (45%)
leucine-rich repeat 132..155 CDD:275380 7/47 (15%)
leucine-rich repeat 156..179 CDD:275380 9/22 (41%)
PCC 161..>235 CDD:188093 21/75 (28%)
Ig 263..349 CDD:319273 27/96 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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