DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Lrig2

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001020238.1 Gene:Lrig2 / 269473 MGIID:2443718 Length:1054 Species:Mus musculus


Alignment Length:903 Identity:170/903 - (18%)
Similarity:286/903 - (31%) Gaps:325/903 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 PRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNAN-------------LTHI 104
            ||:.|.     :|....:::..|.|.|       :.:..:|:|.:..|             |.|:
Mouse   164 PRMSLK-----YLNLSNNRISTLEAGC-------FDNLSDSLLVVKLNRNRISMIPPKVFKLPHL 216

  Fly   105 PQPLDAGTQLLDLSGNEIQLIPD------DSFATAQL---------------LN----------- 137
                    |.|:|..|.|:::..      ||..:.::               ||           
Mouse   217 --------QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 273

  Fly   138 --------------LQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRE 188
                          ||::|:::..:..|...|:.....|.|||||.|.|:.:...|...:|.|..
Mouse   274 LTGVNKGWLYGLRMLQQLYMSQNAIEKISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLER 338

  Fly   189 LRLSGNPILRVPD---------------------------DAFGHVPQLVKLELSDCRLSHIAVR 226
            |.|..|.:..:.|                           :||..:..|.||.|...|:..:..:
Mouse   339 LNLGDNRVTHIADGVFRFLSNLQTLDLRNNDISWAIEDASEAFSGLKSLTKLILQGNRIKSVTQK 403

  Fly   227 AFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGI 291
            ||.||| |||:|.|:.|.:..::.... |...|.||.|..::..|.|.|:.|..|::..|....:
Mouse   404 AFIGLE-SLEYLDLNNNAIMSIQENAF-SQTHLKGLVLNTSSLLCDCHLKWLLQWLVDNNFHHSV 466

  Fly   292 PPTCESPPRLSGRAWDKLDVDDFAC----VPQIVATDTTAHGVEGRNITMSC-YVEGVPQP-AVK 350
            ..:|..|..|:|::...:|:.||.|    .|||.....:...:.|.|:|::| .|.....| :..
Mouse   467 NVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPESTIALRGVNVTLTCTAVSSSDSPMSTI 531

  Fly   351 WLLKNRLIANLSAGG-------DGDS--------------------------------------- 369
            |...:.::.::....       ||::                                       
Mouse   532 WRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLT 596

  Fly   370 ------------DSEPRTAA------ATQGRKTYVVNMLRNASN------------------LTI 398
                        |...||.|      |.:|..|..::..::...                  ..|
Mouse   597 VNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFI 661

  Fly   399 LTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAPWGVRIILLGAVAALLLVGGSSFAAIC 462
            ....::|.|||:|.|:|.||.:.|:.:|.|...|. ..|...:.:..|..|.|..:.|.|.|   
Mouse   662 ANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPA--- 723

  Fly   463 LCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLR 527
                                     .::..|....|.|                   ..|:.:..
Mouse   724 -------------------------PRLNWTKDDGPLL-------------------VTERHFFA 744

  Fly   528 AAHTPL-----NDNDAGQAAAIVNPSAGSAQRRNGDYLHV--STHCDDEEEDQQLHHHPQQQPAS 585
            ||:..|     ...|||:...:::.:.|:  .|...||:|  |.:||..:             :|
Mouse   745 AANQLLIIVDAGLEDAGKYTCLMSNTLGT--ERGHIYLNVISSPNCDSSQ-------------SS 794

  Fly   586 QHHPHPNQQ------------------------QHQQRKGSQGHVVSASGANNSAPLEETDLHIP 626
            ..|......                        .|.:||.....:.:....|..|       .||
Mouse   795 IGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPA-------DIP 852

  Fly   627 RLIDIGGTDSASSSISSQVDAAAR---LAGYAGHTWKTTP------------------IATTKIN 670
            ..:...||.|......|..:|.:.   :....|:|.:.|.                  .:.|:..
Mouse   853 SYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYTHRGTDGGAGTRVICSDCYDNANIYSRTREY 917

  Fly   671 SPHS----KPVTSAAPSSLNTQATPYAHYGNHPADEMAT--SVFCSEGQESDLFDSNY 722
            .|::    :.|...|.|||..| .|...:.:||..:.|.  |:..|..:|...|.:|:
Mouse   918 CPYTYIAEEDVLDQALSSLMVQ-MPKETFLSHPPQDAANLESLIPSAEREPAAFPTNH 974

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 52/229 (23%)
leucine-rich repeat 112..137 CDD:275380 7/45 (16%)
LRR_8 137..196 CDD:290566 20/83 (24%)
leucine-rich repeat 138..161 CDD:275380 5/22 (23%)
leucine-rich repeat 162..185 CDD:275380 9/22 (41%)
LRR_8 184..245 CDD:290566 24/87 (28%)
leucine-rich repeat 186..209 CDD:275380 7/49 (14%)
leucine-rich repeat 210..234 CDD:275380 10/23 (43%)
leucine-rich repeat 235..258 CDD:275380 6/22 (27%)
LRRCT 267..316 CDD:214507 13/48 (27%)
IG_like 328..428 CDD:214653 28/183 (15%)
Ig 335..425 CDD:143165 25/173 (14%)
Lrig2NP_001020238.1 LRR_RI <16..204 CDD:238064 10/51 (20%)
leucine-rich repeat 53..75 CDD:275378
LRR 1 75..96
LRR 2 97..118
leucine-rich repeat 98..120 CDD:275380
LRR_8 119..178 CDD:290566 4/18 (22%)
LRR 3 120..141
leucine-rich repeat 121..144 CDD:275380
LRR_RI <136..344 CDD:238064 39/199 (20%)