DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and LRIT1

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_056428.1 Gene:LRIT1 / 26103 HGNCID:23404 Length:623 Species:Homo sapiens


Alignment Length:476 Identity:122/476 - (25%)
Similarity:170/476 - (35%) Gaps:111/476 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LLWLLCCCSQLGQLRAECPAVCECKWK-----SGKESVLCLNANLTHIPQPLDAGTQLLDLSGNE 121
            :|||| ..:...|.|..||:.|.|...     |...:|:|.:.::|..|..:...|..|.|....
Human     7 MLWLL-ALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTA 70

  Fly   122 IQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSEL 186
            |:.:|.:                          |||.|..|.:|.|..|.||.:.:|.|..:..|
Human    71 IRRVPGE--------------------------AFRPLGRLEQLWLPYNALSELNALMLRGLRRL 109

  Fly   187 RELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSG 251
            |||||.||.:...|..|....|:|..|:|...|||.:...|...|| :|.:|.|..|:|..:...
Human   110 RELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLE-NLTFLDLSSNQLMRLPQE 173

  Fly   252 TITSLASLHG------------LELARNTWNCSCSLRPLRAWMLQQNIPSGIPPT---------C 295
            .|.|.|.|..            |.|..|.|.|.|.|..|      .::..|..|.         |
Human   174 LIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDL------VHLLDGWAPNLAFIETELRC 232

  Fly   296 ESPPRLSGRAWDKLDVDDFACV-PQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIA 359
            .||..|:|.|:.:|::.  .|. |::.....:...:.|....:.|...|||.|.:.|...|....
Human   233 ASPRSLAGVAFSQLELR--KCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPL 295

  Fly   360 NLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASV 424
            |.:...:..||....|...           |...|:|        |:|.|.|.|:|..|..|..:
Human   296 NGTVHQEVSSDGTSWTLLG-----------LPAVSHL--------DSGDYICQAKNFLGASETVI 341

  Fly   425 TLAVSRRP--------PEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRR--------KLR 473
            :|.|:..|        |.|.|.             ..||...||.....|..|.        .|.
Human   342 SLIVTEPPTSTEHSGSPGALWA-------------RTGGGGEAAAYNNKLVARHVPQIPKPAVLA 393

  Fly   474 LWNSVPPVRRSESYEKIEMTA 494
            ...|||..:...:.|..:|.|
Human   394 TGPSVPSTKEELTLEHFQMDA 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 48/168 (29%)
leucine-rich repeat 112..137 CDD:275380 5/24 (21%)
LRR_8 137..196 CDD:290566 20/58 (34%)
leucine-rich repeat 138..161 CDD:275380 4/22 (18%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 24/60 (40%)
leucine-rich repeat 186..209 CDD:275380 10/22 (45%)
leucine-rich repeat 210..234 CDD:275380 9/23 (39%)
leucine-rich repeat 235..258 CDD:275380 7/22 (32%)
LRRCT 267..316 CDD:214507 15/57 (26%)
IG_like 328..428 CDD:214653 24/99 (24%)
Ig 335..425 CDD:143165 22/89 (25%)
LRIT1NP_056428.1 LRR 1 60..81 7/46 (15%)
leucine-rich repeat 61..84 CDD:275378 9/48 (19%)
LRR_8 63..143 CDD:290566 30/105 (29%)
LRR 2 84..105 8/20 (40%)
leucine-rich repeat 85..132 CDD:275378 18/46 (39%)
LRR 3 108..129 10/20 (50%)
LRR_8 131..202 CDD:290566 21/71 (30%)
LRR_4 131..171 CDD:289563 15/40 (38%)
LRR 4 132..153 7/20 (35%)
leucine-rich repeat 133..156 CDD:275378 9/23 (39%)
LRR 5 156..177 6/20 (30%)
leucine-rich repeat 157..180 CDD:275378 7/22 (32%)
leucine-rich repeat 181..205 CDD:275378 5/23 (22%)
TPKR_C2 201..>240 CDD:301599 12/44 (27%)
Ig 267..345 CDD:299845 24/96 (25%)
IG_like 267..345 CDD:214653 24/96 (25%)
FN3 431..498 CDD:214495
LRR 6. /evidence=ECO:0000305 571..594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141300
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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