DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and LRRTM2

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_056379.1 Gene:LRRTM2 / 26045 HGNCID:19409 Length:516 Species:Homo sapiens


Alignment Length:336 Identity:79/336 - (23%)
Similarity:114/336 - (33%) Gaps:107/336 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 LGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAG-----------TQL----------- 114
            |..|...||..|.|:    |....|.:.....:|...|.|           |:|           
Human    27 LPALGMACPPKCRCE----KLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQL 87

  Fly   115 --LDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPS 177
              |.|..|:|..:.:|:|  ..|..|:::.|:...:..:....|.:||||..||||.|.||::..
Human    88 TWLHLDHNQISTVKEDAF--QGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHP 150

  Fly   178 LALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAG------------ 230
            ...|.:.:|:.|.|..|.:..:|...|.....|..|:||..||..:|...|||            
Human   151 ELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHN 215

  Fly   231 ----------------------------LESSLEW------------------------------ 237
                                        |...:||                              
Human   216 QLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLK 280

  Fly   238 -LKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM--LQQNIPSGIPPTCESPP 299
             |.:|.|:|:.:.|..:.||.||..:.|:.|.|.||..:..|.:|:  .|......|  .|.||.
Human   281 ILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSI--LCHSPD 343

  Fly   300 RLSGRAWDKLD 310
            ...|.  |.||
Human   344 HTQGE--DILD 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 54/251 (22%)
leucine-rich repeat 112..137 CDD:275380 9/37 (24%)
LRR_8 137..196 CDD:290566 19/58 (33%)
leucine-rich repeat 138..161 CDD:275380 4/22 (18%)
leucine-rich repeat 162..185 CDD:275380 9/22 (41%)
LRR_8 184..245 CDD:290566 22/131 (17%)
leucine-rich repeat 186..209 CDD:275380 6/22 (27%)
leucine-rich repeat 210..234 CDD:275380 11/63 (17%)
leucine-rich repeat 235..258 CDD:275380 9/53 (17%)
LRRCT 267..316 CDD:214507 15/46 (33%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
LRRTM2NP_056379.1 LRR 1 63..83 2/19 (11%)
LRR <65..312 CDD:227223 53/248 (21%)
leucine-rich repeat 66..86 CDD:275380 2/19 (11%)
LRR 2 86..107 6/22 (27%)
leucine-rich repeat 87..110 CDD:275380 7/24 (29%)
LRR 3 110..131 3/20 (15%)
leucine-rich repeat 111..134 CDD:275380 4/22 (18%)
LRR 4 134..155 9/20 (45%)
leucine-rich repeat 135..158 CDD:275380 9/22 (41%)
LRR 5 158..179 6/20 (30%)
leucine-rich repeat 159..182 CDD:275380 6/22 (27%)
LRR 6 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 10/22 (45%)
LRR 7 206..227 0/20 (0%)
leucine-rich repeat 207..230 CDD:275380 0/22 (0%)
LRR 8 230..251 2/20 (10%)
leucine-rich repeat 231..254 CDD:275380 3/22 (14%)
LRR 9 254..275 0/20 (0%)
leucine-rich repeat 255..278 CDD:275380 0/22 (0%)
LRR 10 278..299 5/20 (25%)
leucine-rich repeat 279..300 CDD:275380 5/20 (25%)
PCC 284..>351 CDD:188093 22/70 (31%)
Involved in DLG4-binding. /evidence=ECO:0000250 513..516
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141280
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.