DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lgi1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_665712.1	Gene:	Lgi1 / 252892	RGDID:	628742	Length:	557	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	97/409 - (23%)
Similarity:	146/409 - (35%)	Gaps:	118/409 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQL----GQ--LRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDL 117
            |..:.:.||..|.:    |:  .:.:|||||.|    .|::.||.||.  .||
  Rat    16 LKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTC----SKDNALCENAR--SIP------------ 62

  Fly   118 SGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYH 182
                 :.:|.|      :::|..|           |..|        .::|:......|||.|
  Rat    63 -----RTVPPD------VISLSFV-----------RSGF--------TEISEGSFLFTPSLQL-- 95

  Fly   183 VSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSE 247
                  |..:.|....:.||||..:|.|..|.:.:..:..|:...|.||:|.:. |.|..|.|..
  Rat    96 ------LLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIH-LSLANNNLQT 153

  Fly   248 VRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPT-----CESPPRLSGRAWD 307
            :.......|.||..::|..|::||.|.|:.|..|:...|      .|     ||.||....|..:
  Rat   154 LPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTN------ATVEDIYCEGPPEYKKRKIN 212

  Fly   308 KLDVDDFACV----------P-QIVATDT----------TAHGVEGR-----------------N 334
            .|...||.|:          | |.::.||          .|....|:                 |
  Rat   213 SLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDN 277

  Fly   335 ITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTIL 399
            ||.:..|  |.:|.|.......::|.|..|    |....|...|.:..|...:.:|:......|.
  Rat   278 ITGTSTV--VCKPIVIDTQLYVIVAQLFGG----SHIYKRDGFANKFIKIQDIEVLKIRKPNDIE 336

  Fly   400 TADMQDAGIYTCAAENKAG 418
            |..::|...:..|..:|||
  Rat   337 TFKIEDNWYFVVADSSKAG 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	33/156 (21%)
		leucine-rich repeat	112..137	CDD:275380	2/24 (8%)
		LRR_8	137..196	CDD:290566	11/58 (19%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		leucine-rich repeat	162..185	CDD:275380	5/22 (23%)
		LRR_8	184..245	CDD:290566	17/60 (28%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	17/53 (32%)
		IG_like	328..428	CDD:214653	23/108 (21%)
		Ig	335..425	CDD:143165	21/84 (25%)
Lgi1	NP_665712.1	leucine-rich repeat	71..92	CDD:275378	5/39 (13%)
		LRR_8	91..151	CDD:404697	21/68 (31%)
		LRR 1	92..113		9/28 (32%)
		leucine-rich repeat	93..116	CDD:275378	8/30 (27%)
		LRR 2	116..137		4/20 (20%)
		leucine-rich repeat	117..140	CDD:275378	6/22 (27%)
		LRR 3	140..161		5/21 (24%)
		leucine-rich repeat	141..164	CDD:275378	5/23 (22%)
		PCC	146..>221	CDD:188093	24/80 (30%)
		leucine-rich repeat	165..177	CDD:275378	3/11 (27%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	225..267		6/41 (15%)
		EPTP	225..264	CDD:397689	6/38 (16%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	271..313		12/47 (26%)
		EPTP	272..310	CDD:397689	11/43 (26%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	317..364		9/39 (23%)
		EPTP	317..361	CDD:397689	9/39 (23%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	366..415
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	419..462
		EPTP	420..459	CDD:397689
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	464..506
		EPTP	464..502	CDD:397689
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	510..552
		EPTP	510..549	CDD:397689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335010
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840