DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lgi2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_659194.1	Gene:	Lgi2 / 246316	MGIID:	2180196	Length:	550	Species:	Mus musculus

Alignment Length:	267	Identity:	60/267 - (22%)
Similarity:	95/267 - (35%)	Gaps:	86/267 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQLGQLR--AECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQ 123
            |||...|......|:|  |.|||.|.|.    |||::|:.:  :.:|                 :
Mouse    13 LLLSAACLIPPSAQVRRLARCPATCSCT----KESIICVGS--SWVP-----------------R 54

  Fly   124 LIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRE 188
            ::|.|..:.:                         |:|...|::...:.|.:|||.|
Mouse    55 IVPGDISSLS-------------------------LVNGTFLEIKDRMFSHLPSLQL-------- 86

  Fly   189 LRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTI 253
            |.|:.|....:.||                        ||||| ..||:|.::||::..:.....
Mouse    87 LLLNSNSFTVIRDD------------------------AFAGL-FHLEYLFIEGNKIETISRNAF 126

  Fly   254 TSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPT-CESPPRLSGRAWDKLDVDDFACV 317
            ..|..|..|:|..|.:.|.|..:.|..|:...|  |.:... |..||....:..:::...|:.|.
Mouse   127 RGLRDLTHLDLRGNKFECDCKAKWLYLWLKMTN--STVSDVLCIGPPEYQEKKLNEVTSFDYECT 189

  Fly   318 PQIVATD 324
            .....||
Mouse   190 TTGPQTD 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	29/156 (19%)
		leucine-rich repeat	112..137	CDD:275380	2/24 (8%)
		LRR_8	137..196	CDD:290566	11/58 (19%)
		leucine-rich repeat	138..161	CDD:275380	1/22 (5%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	15/60 (25%)
		leucine-rich repeat	186..209	CDD:275380	5/22 (23%)
		leucine-rich repeat	210..234	CDD:275380	5/23 (22%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	11/49 (22%)
		IG_like	328..428	CDD:214653
		Ig	335..425	CDD:143165
Lgi2	NP_659194.1	leucine-rich repeat	63..83	CDD:275380	4/44 (9%)
		LRR_8	94..142	CDD:290566	17/72 (24%)
		LRR_4	107..143	CDD:289563	10/35 (29%)
		leucine-rich repeat	108..131	CDD:275378	6/22 (27%)
		TPKR_C2	140..>174	CDD:301599	10/35 (29%)
		EPTP	224..265	CDD:281697
		EPTP	271..311	CDD:281697
		EPTP	316..362	CDD:281697
		EPTP	365..407	CDD:281697
		EPTP	412..454	CDD:281697
		EPTP	457..498	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840