DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lrit1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	850	Identity:	176/850 - (20%)
Similarity:	261/850 - (30%)	Gaps:	311/850 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLWLLCCCSQLG---QLRAECPAVCECKWK-----SGKESVLCLNANLTHIPQPLDAGTQLLDLS 118
            :||||.    ||   |....||:.|.|..:     |...:|:|.:.:||..|..
Mouse     7 MLWLLA----LGGPHQAWGFCPSECSCSLRILSDGSKARTVVCSDPDLTLPPAS----------- 56

  Fly   119 GNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHV 183
                  ||.|:.         |:.|.|..:|.:....||.|..|.:|.|..|.||.:.:|.|..:
Mouse    57 ------IPPDTC---------KLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALMLRGL 106

  Fly   184 SELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRL--- 245
            ..||||||.||.::..|..|....|||..|:|...|||.:...|...|| :|.:|.|..|:|
Mouse   107 RRLRELRLPGNRLVTFPWAALRDTPQLQLLDLQANRLSTLPPEAAHFLE-NLTFLDLSNNQLMRL 170

  Fly   246 --------SEVRSGTITSLASLHG---LELARNTWNCSCSL----RPLRAWMLQQNIPSGIPPTC 295
                    :.:::|..  |:..|.   |.|..|.|.|.|.|    ..|..|:....|.......|
Mouse   171 PEELLDVWAHLKTGPF--LSGHHARLILGLQDNPWVCDCRLYDLVHLLDGWVSSNLIFIEARLRC 233

  Fly   296 ESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIA 359
            .||..|:|.|:.:|::.  .| .|::....|:.....|..:.:.|...|:|.|.:.|...|....
Mouse   234 ASPRSLAGVAFSQLELR--KCQSPELRPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPL 296

  Fly   360 NLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASV 424
            |.:...:..||....|.                   |.:....:.|:|.|.|.|:|..|..|..:
Mouse   297 NGTVHQEVSSDGSSWTL-------------------LDLPVVSLFDSGDYICQAKNFLGASETLI 342

  Fly   425 TLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEK 489
            :|.|:.  |:...|                                    ::.:|.|
Mouse   343 SLIVTE--PQTSTG------------------------------------YSGIPGV-------- 361

  Fly   490 IEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQR 554
              :.|||    |.||..             |.....|.|.|.|
Mouse   362 --LWART----GEGAEA-------------AAYNNKLVARHVP---------------------- 385

  Fly   555 RNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLE 619
                                  |.|:....:   ..|:....::....|...:...|..:..|.|
Mouse   386 ----------------------HMPEHVALA---TKPSMPSIKEELALQNFQMDVPGEFSREPSE 425

  Fly   620 ETDLHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSS 684
            ..:..:.|.:.:.|....|.|:                .||                    ||.:
Mouse   426 HQEAQMVRSLKVVGDTYHSVSL----------------VWK--------------------APQA 454

  Fly   685 LNTQA--TPYAHYGNHPADEMA-----TSV--------------FCSEG-----QESDLFDSN-- 721
            .||.|  ..||.:|:.....|.     |||              .|..|     ::..:|.::
Mouse   455 GNTTAFSVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEV 519

  Fly   722 ----------------------YPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLK 764
                                  .|..|.:...|:.:...:.|..|.|:|    :|....|.|
Mouse   520 VDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRTGGSAEA----SGAYVNLER--- 577

  Fly   765 TSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGGGQ 829
                 ..:|.||...|        ..|:|.:|.         |..||.||   ..|......||:
Mouse   578 -----LGHSEDSSEVL--------SRSSLSEGD---------RLLSARSS---LDSQVLGVRGGR 617

  Fly   830 RANSF 834
            |.|.:
Mouse   618 RINEY 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	49/170 (29%)
		leucine-rich repeat	112..137	CDD:275380	3/24 (13%)
		LRR_8	137..196	CDD:290566	23/58 (40%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	25/60 (42%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	7/33 (21%)
		LRRCT	267..316	CDD:214507	15/52 (29%)
		IG_like	328..428	CDD:214653	21/99 (21%)
		Ig	335..425	CDD:143165	19/89 (21%)
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470	12/54 (22%)
		LRR 1	60..81		6/29 (21%)
		LRR_8	63..143	CDD:290566	30/79 (38%)
		leucine-rich repeat	64..84	CDD:275378	6/19 (32%)
		LRR 2	84..105		8/20 (40%)
		leucine-rich repeat	85..132	CDD:275378	18/46 (39%)
		LRR 3	108..129		10/20 (50%)
		LRR_8	131..>176	CDD:290566	16/45 (36%)
		LRR_4	131..172	CDD:289563	16/41 (39%)
		LRR 4	132..153		8/20 (40%)
		leucine-rich repeat	133..156	CDD:275378	9/23 (39%)
		LRR 5	156..177		5/20 (25%)
		leucine-rich repeat	157..180	CDD:275378	5/22 (23%)
		leucine-rich repeat	181..205	CDD:275378	7/25 (28%)
		TPKR_C2	201..>241	CDD:301599	12/39 (31%)
		Ig	258..346	CDD:299845	22/106 (21%)
		IG_like	268..346	CDD:214653	21/96 (22%)
		FN3	432..502	CDD:214495	19/105 (18%)
		LRR 6	526..549		2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840