DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and FLRT2

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001333072.1 Gene:FLRT2 / 23768 HGNCID:3761 Length:660 Species:Homo sapiens


Alignment Length:384 Identity:96/384 - (25%)
Similarity:151/384 - (39%) Gaps:127/384 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 PLH--LHLLLWLLCCC---SQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLL 115
            |.|  ..|..||:...   ||:.:|.| ||:||.|    .:..|.|...:||.:|..:..|..:|
Human     9 PSHGAFFLKSWLIISLGLYSQVSKLLA-CPSVCRC----DRNFVYCNERSLTSVPLGIPEGVTVL 68

  Fly   116 DLSGNEI-----------------------QLIPDDSF------------------------ATA 133
            .|..|:|                       ||   |.|                        |.|
Human    69 YLHNNQINNAGFPAELHNVQSVHTVYLYGNQL---DEFPMNLPKNVRVLHLQENNIQTISRAALA 130

  Fly   134 QLLNLQKVYLARCHLRL--IERHAFRKLINLVELDLSQNLLSAIP-SLALYHVSELRELRLSGNP 195
            |||.|::::|....:..  :|..|||:.|:|..|.||:|.||::| .|.:    :|:|||:..|.
Human   131 QLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPV----DLQELRVDENR 191

  Fly   196 ILRVPDDAF------------------------------------------GHVP------QLVK 212
            |..:.|.||                                          .|.|      .|::
Human   192 IAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIR 256

  Fly   213 LELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRP 277
            |.|.|.:::||.:.||:.|. .||.|.:..|:|..:..|...:|::|..|....|.|.|.||::.
Human   257 LYLQDNQINHIPLTAFSNLR-KLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKW 320

  Fly   278 LRAWMLQQNIPSGIPP---TCESPPRLSGRAWDKLDVDDFAC------VPQIVATDTTA 327
            :..|:  :.|||.:..   .|:.|.::.|.|..:|:::..:|      :|......:||
Human   321 VTEWL--KYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTA 377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 59/254 (23%)
leucine-rich repeat 112..137 CDD:275380 12/71 (17%)
LRR_8 137..196 CDD:290566 21/61 (34%)
leucine-rich repeat 138..161 CDD:275380 6/24 (25%)
leucine-rich repeat 162..185 CDD:275380 9/23 (39%)
LRR_8 184..245 CDD:290566 24/108 (22%)
leucine-rich repeat 186..209 CDD:275380 11/70 (16%)
leucine-rich repeat 210..234 CDD:275380 9/23 (39%)
leucine-rich repeat 235..258 CDD:275380 7/22 (32%)
LRRCT 267..316 CDD:214507 14/51 (27%)
IG_like 328..428 CDD:214653 96/384 (25%)
Ig 335..425 CDD:143165
FLRT2NP_001333072.1 LRRNT 35..66 CDD:214470 12/35 (34%)
NEL <54..>265 CDD:330839 48/217 (22%)
LRR 1 64..85 5/20 (25%)
leucine-rich repeat 65..86 CDD:275378 4/20 (20%)
LRR 2 89..109 4/22 (18%)
leucine-rich repeat 90..110 CDD:275380 4/22 (18%)
LRR 3 110..131 1/20 (5%)
leucine-rich repeat 111..134 CDD:275380 4/22 (18%)
LRR 4 134..155 3/20 (15%)
leucine-rich repeat 135..160 CDD:275380 6/24 (25%)
LRR 5 160..181 9/24 (38%)
leucine-rich repeat 161..181 CDD:275380 9/23 (39%)
leucine-rich repeat 182..205 CDD:275380 9/22 (41%)
LRR 6 182..202 9/19 (47%)
LRR 7 205..225 0/19 (0%)
leucine-rich repeat 206..231 CDD:275380 0/24 (0%)
LRR 8 231..252 2/20 (10%)
leucine-rich repeat 232..253 CDD:275380 2/20 (10%)
LRR_8 252..311 CDD:316378 18/59 (31%)
LRR 9 253..274 8/20 (40%)
leucine-rich repeat 254..277 CDD:275380 9/23 (39%)
LRR 10 277..298 6/20 (30%)
leucine-rich repeat 278..301 CDD:275380 7/22 (32%)
PCC 282..>359 CDD:188093 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..413 2/5 (40%)
fn3 426..494 CDD:306538
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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