DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and Lingo3

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001013780.2 Gene:Lingo3 / 237403 MGIID:3609246 Length:589 Species:Mus musculus


Alignment Length:623 Identity:148/623 - (23%)
Similarity:211/623 - (33%) Gaps:217/623 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLS--- 118
            |.|||||      .....|.|.|||.|||  .:...:|.|....||.||:.:.|.|::|:||   
Mouse     8 LGLHLLL------LPTAPLAAGCPARCEC--SASTRTVACGRRRLTAIPEGIPAETRMLELSRNR 64

  Fly   119 ---------------------------------------------GNEIQLIP------------ 126
                                                         ||:::|||            
Mouse    65 IRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDSLTL 129

  Fly   127 ------------DDSF----------------------ATAQLLNLQKVYLARC----------- 146
                        |.||                      |.|.||.|.::.|.||           
Mouse   130 LDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPESLG 194

  Fly   147 HLR-------------LIERHAFRKL------------------------INLVELDLSQNLLSA 174
            |||             .:|...|:||                        :||..|.::...::|
Mouse   195 HLRGLGALRLRHLAIAALEDQNFQKLPGLSHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTNITA 259

  Fly   175 IPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLK 239
            :|:.||...:.|..|.||.|||..||..:|..:.:|.:|.|:...|:.|..:||.||. .:..|.
Mouse   260 VPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLR-QIRLLN 323

  Fly   240 LDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIP---SGIPPTCESPPRL 301
            |..|.||.:...|..|:.:|..|.:..|...|.|.|    .|::|:...   .|..|.|.:|..:
Mouse   324 LSDNLLSTLEENTFHSVNTLETLRVDGNPLACDCRL----LWIVQRRKTLNFDGRLPACATPAEV 384

  Fly   302 SGRAW----DKLDVDDFACVPQIVATDTTAH--GVEGRNITMSCYVEGVPQPAVKWLLKNRLIAN 360
            .|.|.    |.:..:.|.|....:......|  ..||.::...|..||.|.|.|.|:        
Mouse   385 RGDALHNLPDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWV-------- 441

  Fly   361 LSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVT 425
                    :.......||::||...:     ....|||.....||:|.|||.|.|..|......|
Mouse   442 --------TPQHHSVTAASRGRARVL-----PGGTLTIADTRPQDSGTYTCVASNAGGNDTYFAT 493

  Fly   426 LAVSRRPP----------EAPWGVRIIL-LGAVAALLLVGGSSFAAICL-CSLQRRRKLRLWNSV 478
            |.|  :|.          |...|||..| |..:.....:|..:|..:.| |.|    .|.:|:..
Mouse   494 LTV--QPAANRTQGDGHNETQVGVRFPLDLTTILVSTAMGCITFLGVVLFCFL----LLFVWSRG 552

  Fly   479 PPVRRSE-----SYEKIEMTARTRPDLGGGASCGGGSA 511
            ....::.     |:.|::         |..|:.|.|.|
Mouse   553 RGQHKNNFSVEYSFRKVD---------GPAAAAGQGGA 581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 63/298 (21%)
leucine-rich repeat 112..137 CDD:275380 15/118 (13%)
LRR_8 137..196 CDD:290566 23/106 (22%)
leucine-rich repeat 138..161 CDD:275380 11/70 (16%)
leucine-rich repeat 162..185 CDD:275380 6/22 (27%)
LRR_8 184..245 CDD:290566 22/60 (37%)
leucine-rich repeat 186..209 CDD:275380 10/22 (45%)
leucine-rich repeat 210..234 CDD:275380 9/23 (39%)
leucine-rich repeat 235..258 CDD:275380 7/22 (32%)
LRRCT 267..316 CDD:214507 14/55 (25%)
IG_like 328..428 CDD:214653 28/101 (28%)
Ig 335..425 CDD:143165 23/89 (26%)
Lingo3NP_001013780.2 LRRNT 23..55 CDD:214470 13/33 (39%)
leucine-rich repeat 34..53 CDD:275380 6/18 (33%)
LRR 1 54..75 4/20 (20%)
LRR <55..353 CDD:227223 63/298 (21%)
leucine-rich repeat 55..78 CDD:275380 4/22 (18%)
LRR 2 78..99 0/20 (0%)
leucine-rich repeat 79..102 CDD:275380 0/22 (0%)
LRR 3 102..123 5/20 (25%)
leucine-rich repeat 103..150 CDD:275380 8/46 (17%)
LRR 4 126..147 3/20 (15%)
LRR 5 150..171 1/20 (5%)
leucine-rich repeat 151..174 CDD:275380 3/22 (14%)
LRR 6 174..195 4/20 (20%)
leucine-rich repeat 175..198 CDD:275380 6/22 (27%)
leucine-rich repeat 199..222 CDD:275380 4/22 (18%)
LRR 7 206..227 4/20 (20%)
leucine-rich repeat 223..246 CDD:275380 0/22 (0%)
LRR_8 246..302 CDD:338972 20/55 (36%)
LRR 8 246..267 7/20 (35%)
leucine-rich repeat 247..270 CDD:275380 6/22 (27%)
LRR 9 270..291 10/20 (50%)
leucine-rich repeat 271..292 CDD:275380 10/20 (50%)
LRR 10 294..315 7/20 (35%)
leucine-rich repeat 295..318 CDD:275380 9/23 (39%)
LRR 11 318..339 6/20 (30%)
leucine-rich repeat 321..342 CDD:275380 7/20 (35%)
PCC 331..>405 CDD:188093 19/77 (25%)
I-set 406..496 CDD:369462 28/110 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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