DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Lingo1

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:XP_006511149.1 Gene:Lingo1 / 235402 MGIID:1915522 Length:647 Species:Mus musculus


Alignment Length:534 Identity:119/534 - (22%)
Similarity:170/534 - (31%) Gaps:189/534 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LLLW----LLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNE 121
            |..|    ||...|.|......||..|||  .:...:|||.......:|:.:...|:||||..|.
Mouse    47 LACWQPILLLVLGSVLSGSATGCPPRCEC--SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNR 109

  Fly   122 IQLIPDDSFAT----------------------AQLLNLQKVYLARCHLRLIERHAFRKLINLVE 164
            |:.:..|.||:                      ..|.||:.:.|....|:||....|..|.||.:
Mouse   110 IKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTK 174

  Fly   165 LDLSQNL---------------------------------------------------------- 171
            ||:|:|.                                                          
Mouse   175 LDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALS 239

  Fly   172 --------------------------------------------------------------LSA 174
                                                                          |:|
Mouse   240 HLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 304

  Fly   175 IPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLK 239
            :|.||:.|:..||.|.||.|||..:.......:.:|.:::|...:|:.:...||.|| :.|..|.
Mouse   305 VPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGL-NYLRVLN 368

  Fly   240 LDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPL--RAWMLQQNIPSGIPPTCESPPRLS 302
            :.||:|:.:......|:.:|..|.|..|...|.|.|..:  |.|.|..|...   |||.:|..:.
Mouse   369 VSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQ---PTCATPEFVQ 430

  Fly   303 GRAW----DKLDVDDFACVPQIVATDTTAHGV---EGRNITMSCYVEGVPQPAVKWLLKNRLIAN 360
            |:.:    |.|..:.|.| .:....|..|..|   ||..:...|..:|.|.||:.||        
Mouse   431 GKEFKDFPDVLLPNYFTC-RRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWL-------- 486

  Fly   361 LSAGGDGDSDSEPR---TAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEA 422
                       .||   .:|.:.||.|...:     ..|.:..|.:||.|.|.|.|.|..|....
Mouse   487 -----------SPRKHLVSAKSNGRLTVFPD-----GTLEVRYAQVQDNGTYLCIAANAGGNDSM 535

  Fly   423 SVTLAVSRRPPEAP 436
            ...|.|....|:.|
Mouse   536 PAHLHVRSYSPDWP 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 55/298 (18%)
leucine-rich repeat 112..137 CDD:275380 11/46 (24%)
LRR_8 137..196 CDD:290566 26/178 (15%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
leucine-rich repeat 162..185 CDD:275380 11/142 (8%)
LRR_8 184..245 CDD:290566 19/60 (32%)
leucine-rich repeat 186..209 CDD:275380 8/22 (36%)
leucine-rich repeat 210..234 CDD:275380 7/23 (30%)
leucine-rich repeat 235..258 CDD:275380 6/22 (27%)
LRRCT 267..316 CDD:214507 16/54 (30%)
IG_like 328..428 CDD:214653 27/105 (26%)
Ig 335..425 CDD:143165 23/92 (25%)
Lingo1XP_006511149.1 LRRNT 68..102 CDD:214470 10/35 (29%)
LRR <93..398 CDD:227223 57/305 (19%)
leucine-rich repeat 100..123 CDD:275380 10/22 (45%)
leucine-rich repeat 124..147 CDD:275380 1/22 (5%)
LRR_8 147..206 CDD:338972 14/58 (24%)
leucine-rich repeat 148..171 CDD:275380 7/22 (32%)
leucine-rich repeat 172..219 CDD:275380 5/46 (11%)
leucine-rich repeat 220..243 CDD:275380 0/22 (0%)
leucine-rich repeat 244..291 CDD:275380 0/46 (0%)
leucine-rich repeat 292..315 CDD:275380 6/22 (27%)
leucine-rich repeat 316..339 CDD:275380 8/22 (36%)
leucine-rich repeat 340..363 CDD:275380 7/23 (30%)
leucine-rich repeat 364..384 CDD:275380 5/19 (26%)
PCC 368..>448 CDD:188093 23/82 (28%)
Ig 466..541 CDD:386229 25/98 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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