Protein Alignment kek3 and SLITRK3

DIOPT Version :9

• Sequence 1: NP_001162986.1
• Gene: kek3 / 34912
• FlyBaseID: FBgn0028370
• Length: 1021
• Species: Drosophila melanogaster
• Sequence 2: NP_001305739.1
• Gene: SLITRK3 / 22865
• HGNCID: 23501
• Length: 977
• Species: Homo sapiens
• Alignment Length: 848
• Identity: 174/848 - (20%)
• Similarity: 268/848 - (31%)
• Gaps: 313/848 - (36%)

  Fly    26 SAQRRTLATKVRRKGPRP---QRRLH-----PPL-----RPRLPLHLHLLLWLLCCCSQLGQLRA 77
            |:.::...||..|. |||   .:.|:     ||:     ||.:|:
Human   328 SSNKQPKPTKQPRT-PRPPSTSQALYPGPNQPPIAPYQTRPPIPI-------------------- 371

  Fly    78 ECPAVCECKWKSGK--ESVLCLNANLTHI----PQPLDAGTQLLDLSGNEIQLIPDDSFATAQLL 136
            .||..|.|......  .:|.|......:|    |:||:|  :.|.||.|.||.|....|.....|
Human   372 ICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNA--KKLYLSSNLIQKIYRSDFWNFSSL 434

  Fly   137 NLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPD 201
            :|  ::|....:..::..||..|.||..|.|:.|.:..:.......:..|..|....|.|..:..
Human   435 DL--LHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQP 497

  Fly   202 DAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVR-SGTITSLASLHGLELA 265
            .||..:|.|..|.|::..|..:...||||  :||..|.|..|....:. :|.:..|.::..::|.
Human   498 AAFSLMPNLKLLFLNNNLLRTLPTDAFAG--TSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLN 560

  Fly   266 RNTWNCSCSLRPLRAWMLQQNIPSGIPPT-CESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHG 329
            .|.|:|:|.|.|.:.|:...:..|.:... |.||..|:.|  |...::.....|:::..
Human   561 ENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHR--DVRTIELEVLCPEMLHV------ 617

  Fly   330 VEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNAS 394
                            .||                  |:|.::|..:
Human   618 ----------------APA------------------GESPAQPGDS------------------ 630

  Fly   395 NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVA---ALLLVGGS 456
                          :...|...|...|.|        ||..|..:.:::|..:.   :.:.|...
Human   631 --------------HLIGAPTSASPYEFS--------PPGGPVPLSVLILSLLVLFFSAVFVAAG 673

  Fly   457 SFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTA------RTRPDLGGGASCGGGSATGAG 515
            .||.:    |:||||     .:|  .||:..|.:::|.      |...|.|||   ||||..|..
Human   674 LFAYV----LRRRRK-----KLP--FRSKRQEGVDLTGIQMQCHRLFEDGGGG---GGGSGGGGR 724

  Fly   516 LFHDAEEQG--------YLRAAHTPLNDN------DAGQAAAIVNPSAGSAQRRN--------GD 558
            ....:.|:.        |:....|.:.:|      :..:.|......||||:|..        |:
Human   725 PTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSAERGGPGTQPPGMGE 789

  Fly   559 YL---------------HVSTHCDDEEE------DQQL-------HHHPQQQPASQHHPHPNQQ- 594
            .|               :..|..:.|:|      ..||       ||||       |||.....
Human   790 ALLGSEQFAETPKENHSNYRTLLEKEKEWALAVSSSQLNTIVTVNHHHP-------HHPAVGGVS 847

  Fly   595 -------------QHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASSSIS-SQV 645
                         :|.::.|  |.|:...|                    ||..|.|..:. .:.
Human   848 GVVGGTGGDLAGFRHHEKNG--GVVLFPPG--------------------GGCGSGSMLLDRERP 890

  Fly   646 DAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCS 710
            ..|....|:....:.|.|    |:...|..|
Human   891 QPAPCTVGFVDCLYGTVP----KLKELHVHP---------------------------------- 917

  Fly   711 EGQESDLFDSNYPDLLDIAKYAVAQAQQEGR---------GQGYAQATTTPNGGLCTLPRKLKTS 766
            .|.:       ||||           ||:.|         |:|:....|..:..| .|..||:|.
Human   918 PGMQ-------YPDL-----------QQDARLKETLLFSAGKGFTDHQTQKSDYL-ELRAKLQTK 963

  Fly   767 GKY 769
            ..|
Human   964 PDY 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	43/157 (27%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	13/58 (22%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	4/22 (18%)
		LRR_8	184..245	CDD:290566	20/60 (33%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	6/23 (26%)
		LRRCT	267..316	CDD:214507	14/49 (29%)
		IG_like	328..428	CDD:214653	9/99 (9%)
		Ig	335..425	CDD:143165	9/89 (10%)
SLITRK3	NP_001305739.1	leucine-rich repeat	81..102	CDD:275380
		leucine-rich repeat	103..126	CDD:275380
		LRR_8	105..161	CDD:316378
		leucine-rich repeat	127..150	CDD:275380
		LRR_8	150..208	CDD:316378
		leucine-rich repeat	151..174	CDD:275380
		leucine-rich repeat	175..197	CDD:275380
		leucine-rich repeat	198..402	CDD:275380	20/94 (21%)
		leucine-rich repeat	224..271	CDD:275380
		LRRCT	232..>270	CDD:214507
		leucine-rich repeat	272..410	CDD:275380	23/102 (23%)
		leucine-rich repeat	403..433	CDD:275380	12/31 (39%)
		LRR_8	432..492	CDD:316378	14/61 (23%)
		leucine-rich repeat	434..457	CDD:275380	6/24 (25%)
		leucine-rich repeat	458..481	CDD:275380	4/22 (18%)
		leucine-rich repeat	482..501	CDD:275380	5/18 (28%)
		leucine-rich repeat	506..528	CDD:275380	8/23 (35%)
		leucine-rich repeat	529..553	CDD:275380	6/23 (26%)
		LRRCT	562..>597	CDD:214507	11/34 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910