DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Chadl

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_006520805.1	Gene:	Chadl / 214685	MGIID:	3036284	Length:	759	Species:	Mus musculus

Alignment Length:	1070	Identity:	212/1070 - (19%)
Similarity:	303/1070 - (28%)	Gaps:	473/1070 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQLGQLRAE-CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQL 124
            |||:::...|....:.|: ||..|.|  .:.:..|.|.:.|||.:|..:...||.|||.||.:::
Mouse    24 LLLFMVLLQSPAWHVAAQRCPQTCVC--DNSRRHVTCRHQNLTEVPNTIPELTQRLDLQGNILKV 86

  Fly   125 IPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELREL 189
            :|..:|  ..|.:|..:.|..|.:.::...|||.|..|:.|:|:.|.||.:|..||..:..||.|
Mouse    87 LPAAAF--QDLPHLTHLDLRNCQVEMVAEGAFRGLGRLLLLNLASNRLSTLPQEALDGLGSLRRL 149

  Fly   190 RLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLD------------- 241
            .|.||.:..:....||.:..|..|.|:...|.::...||.||..: .||:|.
Mouse   150 ELEGNMLEELRPGTFGALGSLTTLNLAHNALVYLPAMAFQGLLRT-RWLQLSHNALSVLAPEALA 213

  Fly   242 -------------------GNRLSEVRS--------------------------------GTITS 255
                               |..||:.||                                |::.:
Mouse   214 GLPALRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDHGSLQA 278

  Fly   256 LA--------SLHGLELARN-----------------------TWNCSCSLRPLRAWMLQQNIPS 289
            |.        .||.|:|..|                       .| |:|..|||..|:::..:.|
Mouse   279 LGPRAFAHCPRLHTLDLRGNQLTTLPPLQVPGQLRRLRLQGNPLW-CACHARPLLEWLVRARVRS 342

  Fly   290 GIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLK 354
              ...|..|.||.|.|.|.|...|..|.....|.|
Mouse   343 --DGACRGPRRLRGEALDTLRPSDLRCPGDAAAGD------------------------------ 375

  Fly   355 NRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGK 419
                      ||||.|.:                               :.||
Mouse   376 ----------GDGDEDED-------------------------------RPAG------------ 387

  Fly   420 VEASVTLAVSRRPP------EAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSV 478
                     .|.||      ||.|                 .:.....|.|..:.|.
Mouse   388 ---------PRAPPLRSPHGEAAW-----------------ATPCPPACACVAETRH-------- 418

  Fly   479 PPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGY--------LRAAHTPLND 535
                                     ::|     .|.||  .|..:|:        ||..|.|
Mouse   419 -------------------------STC-----DGRGL--QAVPRGFPNDTQLLDLRRNHFP--- 448

  Fly   536 NDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEE--------EDQQLHHHPQQQPASQHHPHPN 592
                     ..|.|.....|:...||:. ||...|        .|:.|:.:
Mouse   449 ---------SVPRAAFPGLRHLVSLHLQ-HCGVAELEPGALAGLDRLLYLY-------------- 489

  Fly   593 QQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSAS----SSISSQVDAAARLAG 653
             ..|.|..|     :||:....:..|....|...|.:.|.||...:    .|:..|.:|..|||
Mouse   490 -LSHNQLSG-----LSAAALEGAPNLGYLYLEHNRFLRIPGTALRALPTLVSLHLQDNAVDRLA- 547

  Fly   654 YAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESDLF 718
             .|.......:....::..|   :|..:|.:|.            ||.|:          |....
Mouse   548 -PGDLAGARALRCLYLSGNH---ITQVSPGALG------------PAREL----------EKLHL 586

  Fly   719 DSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLP--RKLKTSGKYFRNSSDSQSPLL 781
            |.|                         :....|.|.|..||  ::|:.||          :||.
Mouse   587 DRN-------------------------RLREVPTGALEGLPALKELQLSG----------NPLR 616

  Fly   782 ADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYS-----STATYTGGGQRANSFLNLVQSG 841
            |          |.||:|    ..:||  |.:..:.|.|     |...::|.|:...|
Mouse   617 A----------LPDGAF----QPVGR--SLQQLFLNSSDLEQISPRAFSGLGKGLRS-------- 657

  Fly   842 AHQGKLLPSHLGQKPSLPSSPVQHQRSLSSAATPLLDFSALASRAAGAANTSVAAYDYHAAQLER 906
                  |..|..|..|||:       .|..:...|:|.|......           |.....|.|
Mouse   658 ------LYLHKNQLQSLPA-------PLGLSGLELVDLSGNPFHC-----------DCQLLPLHR 698

  Fly   907 FLEEYRNLQDQLCKMKETCDTIRKKETPLRVAIGQSAAQLADPVMYSAASHSPKPPATSNLKTKT 971
            :|                        |.|.:.:|.:.|               .||:....|.|.
Mouse   699 WL------------------------TGLNLRVGATCA---------------TPPSVRGQKVKV 724

  Fly   972 LLPGQPPDPPPYWLHRNAMLKRL-NGDGSA 1000
            ..|  ..:..|.|..|.|  ||. ...|||
Mouse   725 AAP--VFEACPGWTARKA--KRTPTSRGSA 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	56/228 (25%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	22/58 (38%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	20/92 (22%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	10/94 (11%)
		LRRCT	267..316	CDD:214507	18/71 (25%)
		IG_like	328..428	CDD:214653	7/99 (7%)
		Ig	335..425	CDD:143165	7/89 (8%)
Chadl	XP_006520805.1	PRK15370	<32..>322	CDD:185268	69/294 (23%)
		leucine-rich repeat	54..72	CDD:275380	6/17 (35%)
		leucine-rich repeat	74..97	CDD:275380	10/24 (42%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR_8	169..228	CDD:338972	11/59 (19%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	3/23 (13%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		leucine-rich repeat	266..289	CDD:275380	2/22 (9%)
		leucine-rich repeat	312..351	CDD:275380	10/41 (24%)
		LRRNT	405..439	CDD:214470	9/73 (12%)
		leucine-rich repeat	437..460	CDD:275380	6/34 (18%)
		LRR_8	460..519	CDD:338972	14/79 (18%)
		leucine-rich repeat	461..484	CDD:275380	5/23 (22%)
		leucine-rich repeat	485..508	CDD:275380	6/42 (14%)
		LRR	<507..>687	CDD:227223	57/278 (21%)
		leucine-rich repeat	509..532	CDD:275380	6/22 (27%)
		leucine-rich repeat	533..556	CDD:275380	7/24 (29%)
		leucine-rich repeat	557..580	CDD:275380	6/37 (16%)
		leucine-rich repeat	581..604	CDD:275380	7/57 (12%)
		leucine-rich repeat	605..629	CDD:275380	12/49 (24%)
		leucine-rich repeat	630..653	CDD:275380	4/22 (18%)
		leucine-rich repeat	655..677	CDD:275380	8/42 (19%)
		LRRCT	685..733	CDD:214507	13/99 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840