DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lgi3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_660254.1	Gene:	Lgi3 / 213469	MGIID:	2182619	Length:	548	Species:	Mus musculus

Alignment Length:	392	Identity:	85/392 - (21%)
Similarity:	135/392 - (34%)	Gaps:	115/392 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAE-------CPAVCECKWKSGKESVL 95
            |:|  |.|||             |:|..|..|..| |:.|:       ||..|.|.    :::..
Mouse     7 RRG--PGRRL-------------LVLSTLGFCLML-QVSAKRPPKTPPCPPSCSCT----RDTAF 51

  Fly    96 CLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLI 160
            |:::.  .:|:.|.:
Mouse    52 CVDSK--SVPKNLPS-------------------------------------------------- 64

  Fly   161 NLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAV 225
            .::.|.|.....|.|...|..|:..|:.|.|:.|....:.|:||..:..|..|.:.:..:..::.
Mouse    65 EVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFIGLSHLQYLFIENNDIWALSK 129

  Fly   226 RAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSG 290
            ..|.||: ||..|.|..|.|..:.......|..|..|:|..|..||.|.::.|..|:...| .:.
Mouse   130 FTFRGLK-SLTHLSLANNNLQTLPRDIFRPLDILSDLDLRGNALNCDCKVKWLVEWLAHTN-TTV 192

  Fly   291 IPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVK---WL 352
            .|..|.||||........|.:.:|.|    :.||...:.      |:|.       |||.   :|
Mouse   193 APIYCASPPRFQEHKVQDLPLREFDC----ITTDFVLYQ------TLSF-------PAVSAEPFL 240

  Fly   353 LKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTA-----DMQDAGIYTCA 412
            ..:.|...|         ::|..:|.|..:..||...||:...:...:|     .:.|..:|...
Mouse   241 YSSDLYLAL---------AQPGASACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDGQLYVVV 296

  Fly   413 AE 414
            |:
Mouse   297 AQ 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	28/156 (18%)
		leucine-rich repeat	112..137	CDD:275380	0/24 (0%)
		LRR_8	137..196	CDD:290566	10/58 (17%)
		leucine-rich repeat	138..161	CDD:275380	0/22 (0%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	17/60 (28%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	5/23 (22%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	15/48 (31%)
		IG_like	328..428	CDD:214653	19/95 (20%)
		Ig	335..425	CDD:143165	19/88 (22%)
Lgi3	NP_660254.1	LRR_8	68..124	CDD:338972	15/55 (27%)
		leucine-rich repeat	68..89	CDD:275378	6/20 (30%)
		LRR 1	89..110		7/20 (35%)
		leucine-rich repeat	90..113	CDD:275378	7/22 (32%)
		LRR_8	113..172	CDD:338972	16/59 (27%)
		LRR 2	113..134		3/20 (15%)
		leucine-rich repeat	114..137	CDD:275378	5/23 (22%)
		LRR 3	137..158		6/20 (30%)
		leucine-rich repeat	138..161	CDD:275378	6/22 (27%)
		PCC	143..>218	CDD:188093	22/75 (29%)
		leucine-rich repeat	162..174	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	222..264		12/63 (19%)
		EPTP	223..262	CDD:367630	11/60 (18%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	268..310		6/31 (19%)
		EPTP	270..308	CDD:367630	5/29 (17%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	314..361
		EPTP	315..359	CDD:367630
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	363..406
		EPTP	364..404	CDD:367630
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	410..453
		EPTP	<422..451	CDD:367630
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	455..497
		EPTP	456..495	CDD:367630
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	501..543
		EPTP	502..541	CDD:367630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840