DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Elfn2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001345621.1	Gene:	Elfn2 / 207393	MGIID:	3608416	Length:	823	Species:	Mus musculus

Alignment Length:	937	Identity:	197/937 - (21%)
Similarity:	295/937 - (31%)	Gaps:	354/937 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLCCCSQLGQLRAECPAVCECKW--KSGKESV---LCLNANLTH--IPQPLDAGTQLLDLSGNEI 122
            |||.| |.|.:||:|       |  :..|..|   :|......:  |||.:::....|.|:.|::
Mouse    11 LLCVC-QPGAVRADC-------WLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKL 67

  Fly   123 QLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELR 187
            :.:...|.  .:..||..:.|.:..:..||..||....:|..|.|..|.||.:....|..:|.|:
Mouse    68 KAVLYSSL--NRFGNLTDLNLTKNEISYIEDGAFLGQTSLQVLQLGYNRLSNLTEGMLRGMSRLQ 130

  Fly   188 ELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGT 252
            .|.:..|.|..|...||...|.|:.::||..|||                 :|||        .|
Mouse   131 FLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLS-----------------RLDG--------AT 170

  Fly   253 ITSLASLHGLELARNTWNCSCSLRPLRAWMLQ-QNIPSGIPP-TCESP------PRLSGRAWDKL 309
            ..|||||...|||.|.:||.|.|....||::. .|:...... .||||      |.|..|.:..|
Mouse   171 FASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSL 235

  Fly   310 DV----------------------------------------DDFACV--PQIVATDTTA----- 327
            :.                                        |:...|  |....||.:|
Mouse   236 NAITVLQAKCRNGSMPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIK 300

  Fly   328 -HGVEGRNITMSCYVEGVPQPAVK---------------WLLKNRL-IANLSAGGDGDSDSEPRT 375
             |.|   ..|.:..|..:|.|..|               ..|||:. |..|.           :.
Mouse   301 LHQV---TFTSATLVVIIPHPYSKMYVLVQYNNSYFSDVMTLKNKKEIVTLD-----------KL 351

  Fly   376 AAATQGRKTYVVNMLRNAS--NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWG 438
            .|.|:  .|:.|..|||:.  |.|.||...:|                    |......|.....
Mouse   352 RAHTE--YTFCVTSLRNSRRFNHTCLTFTTRD--------------------LVPGDLAPSTSTT 394

  Fly   439 VRII--LLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLG 501
            ...|  :||.:..:::|.|:.:  .||    |:|:::           |..:|.....:|..::.
Mouse   395 THYIMTILGCLFGMVIVLGAVY--YCL----RKRRMQ-----------EEKQKSVNVKKTILEMR 442

  Fly   502 GGASCGGGSATGAGLFHDAEEQG------YLRAAHTPLNDND-----AGQAAAIVNPSAGSAQRR 555
            .||....||     :.|.|::.|      ..|.:..|....:     .|..|.:..|...:
Mouse   443 YGADVDAGS-----IVHAAQKLGEPPVLPVARMSSIPSMVGEKLPASKGLEAGLDTPKVAT---- 498

  Fly   556 NGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEE 620
            .|:|:.|.|                                           .|:|.:.:.|.||
Mouse   499 KGNYIEVRT-------------------------------------------GAAGDSLARPEEE 520

  Fly   621 TDLHIPRLIDIGGTDSASSSISSQVDAAARL-----------------AGYAGHTWKTTPIATTK 668
                :|.:.:..|:.:..|:|:.:||...::                 .|..|.....:.:|...
Mouse   521 ----LPEIENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLGGGGGGGGGGDSDLAFEC 581

  Fly   669 INSPHSKPVTSAA-PSSLNTQ---ATPYAHYGNHP------ADEMATSVFCSEG-----QESDLF 718
            .:.|.:...:||| |.:|...   :.||....:||      ||...:...||..     :.:.:|
Mouse   582 QSLPAAPAASSAATPGALERPSFLSPPYKESSHHPLQRQLSADAAVSRKTCSVSSSGSIKSAKVF 646

  Fly   719 DSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPL--- 780
            ..:.||                        ..||.|       ..|:..||....|...|||
Mouse   647 SLDVPD------------------------HPTPTG-------LAKSDSKYIEKGSPLNSPLDRL 680

  Fly   781 -LADNSSKYGSSTLGDG-----------------------------------SFLNEAMGLGRR- 808
             |....|. |||..|.|                                   ||| :.:...:|
Mouse   681 PLVPTGSS-GSSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVSFL-KPLTRSKRD 743

  Fly   809 -----------YSAESSYANYSSTATY 824
                       ||..||...|||.:|:
Mouse   744 STYSQLSPRHYYSGYSSSPEYSSESTH 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	45/156 (29%)
		leucine-rich repeat	112..137	CDD:275380	4/24 (17%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	18/60 (30%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	17/96 (18%)
		IG_like	328..428	CDD:214653	25/117 (21%)
		Ig	335..425	CDD:143165	22/107 (21%)
Elfn2	NP_001345621.1	LRR 1	56..77		4/22 (18%)
		leucine-rich repeat	60..80	CDD:275378	4/21 (19%)
		LRR_8	80..139	CDD:404697	18/58 (31%)
		LRR 2	80..101		7/20 (35%)
		leucine-rich repeat	81..104	CDD:275378	6/22 (27%)
		LRR 3	104..125		7/20 (35%)
		leucine-rich repeat	105..128	CDD:275378	7/22 (32%)
		LRR_8	127..187	CDD:404697	28/84 (33%)
		LRR 4	128..149		7/20 (35%)
		leucine-rich repeat	129..152	CDD:275378	7/22 (32%)
		LRR 5	152..173		10/45 (22%)
		leucine-rich repeat	153..166	CDD:275378	6/29 (21%)
		PCC	157..>227	CDD:188093	30/94 (32%)
		leucine-rich repeat	177..189	CDD:275378	5/11 (45%)
		leucine-rich repeat	200..226	CDD:275380	5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..294		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..624		9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840