DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and slt-1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_510437.2	Gene:	slt-1 / 181562	WormBaseID:	WBGene00004854	Length:	1410	Species:	Caenorhabditis elegans

Alignment Length:	1018	Identity:	208/1018 - (20%)
Similarity:	343/1018 - (33%)	Gaps:	321/1018 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 AECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKV 141
            |.|||.|.|.    ..:|.|:...||.:||.:...|..|||..|||..|..:.|::  |:||:.:
Worm    15 ATCPAECVCV----DRTVSCVGQQLTEVPQNIPNDTIRLDLQDNEITKIGPNDFSS--LMNLKAL 73

  Fly   142 YLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGH 206
            .|....:..|...:|..|:.|.:|.||:|.:..:|.....:..:|..|.||.|.| .|..||...
Worm    74 QLMDNQIVTIHNQSFSSLVFLQKLRLSRNRIRHLPDNVFQNNLKLTHLDLSENDI-TVVSDAQLQ 137

  Fly   207 VPQLVKLELSDCRLSHIAVRAFAGLES-------SLEWLKLDGNRLSEVRSGTITSLASLHGLEL 264
            .|:.  ||:.:...:||..     ||:       |||.|.|:||||:....   .|.|....|:|
Worm   138 GPEF--LEVLNLDKNHIFC-----LENNVISSWVSLEVLTLNGNRLTTFEE---PSNARFRQLDL 192

  Fly   265 ARNTWNCSCSLRPLRAWMLQ---QNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC---------- 316
            ..|.|||.|.||.:|.|:.:   ||     ...|.:|..|.|.:.:.|......|
Worm   193 FNNPWNCDCRLRWMRKWLEKAEGQN-----KTVCATPLNLQGSSIEILQDKFMTCSGNRKRRYKK 252

  Fly   317 ----------------------------VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLL 353
                                        ||..:...||...:|...|:      .:|..:.| .|
Worm   253 TCETAEICPLPCTCTGTTVDCRDSGLTYVPTNLPPSTTEIRLEQNQIS------SIPSHSFK-NL 310

  Fly   354 KNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTAD-----------MQDAG 407
            ||  :..|....:..::.:|:.........|.|:    ..:|:|.|.:|           :.:|.
Worm   311 KN--LTRLDLSKNIITEIQPKAFLGLHNLHTLVL----YGNNITDLKSDTFEGLGSLQLLLLNAN 369

  Fly   408 IYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQ----- 467
            ..||........|.....|::.....::...|....|.:::.|.|   :....||.|:||
Worm   370 QLTCIRRGTFDHVPKLSMLSLYDNDIKSISEVTFQNLTSLSTLHL---AKNPLICDCNLQWLAQI 431

  Fly   468 ----------------RRRKLRLWNSVPP----VRRSESYEK-------IEMTARTRPDLGGGAS 505
                            :|.:.:.:.::||    .:.|||:..       |:....|:.|
Worm   432 NLQKNIETSGARCEQPKRLRKKKFATLPPNKFKCKGSESFVSMYADSCFIDSICPTQCD------ 490

  Fly   506 CGGGSATGAGLFHDAEEQGYLRAAHTPLNDND-----AGQAAAIVNPSAGSAQRRNGDYLHVS-- 563
            |.|.:.       |..::| |....|.:....     :|...:.|:.::......|.:.|.:|
Worm   491 CYGTTV-------DCNKRG-LNTIPTSIPRFATQLLLSGNNISTVDLNSNIHVLENLEVLDLSNN 547

  Fly   564 --THCDDEE------------EDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANN 614
              |..:|:.            .|.:|||.                                   :
Worm   548 HITFINDKSFEKLSKLRELRLNDNKLHHF-----------------------------------S 577

  Fly   615 SAPL-EETDLHIPRLIDIGGTD-SASSSISSQVDAAARLAGYAGH----TWKTTPIAT-TKINSP 672
            |..| |:::|.|   :|:.|.: ...|||........|.....|:    ..:..|:.: .:.||.
Worm   578 SMVLDEQSNLEI---LDLSGNNIQCFSSIFFNKATRIREIKVIGNDLLCDCRILPLMSWLRSNSS 639

  Fly   673 HSKPVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQ 737
            ||..:..                             |.:.|.||    |..|
Worm   640 HSIDIPP-----------------------------CQQFQYSD----NESD------------- 658

  Fly   738 QEGRGQGYAQATTTPNGGLC-----TLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGS 797
             :.|...:.:.|.:.:..||     .|.|.::.|.|   |.:...|.:..|.:..|     .|.:
Worm   659 -KQRCAAFPEETCSDDSNLCPPKCSCLDRVVRCSNK---NLTSFPSRIPFDTTELY-----LDAN 714

  Fly   798 FLNE--AMGLGRRYS--------------AESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGK 846
            ::||  |..|.|.||              ..::::|.:..:|......:......|..:|.:..:
Worm   715 YINEIPAHDLNRLYSLTKLDLSHNRLISLENNTFSNLTRLSTLIISYNKLRCLQPLAFNGLNALR 779

  Fly   847 LLPSHLGQKPSLPSSPVQHQRSLSSAATPLLDFSALASRAAGAANTSVAAYDYHAAQLERFLE-- 909
            :|..|......||.|.                ||.|.|....|..::....|.:.|...::::
Worm   780 ILSLHGNDISFLPQSA----------------FSNLTSITHIAVGSNSLYCDCNMAWFSKWIKSK 828

  Fly   910 ---------EYRN-LQDQLCKMKE----TCDTIRKKETPLRVA 938
                     ||.| :.:||....:    |||:    :.|.::|
Worm   829 FIEAGIARCEYPNTVSNQLLLTAQPYQFTCDS----KVPTKLA 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	51/163 (31%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	17/58 (29%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	23/67 (34%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	6/30 (20%)
		leucine-rich repeat	235..258	CDD:275380	9/22 (41%)
		LRRCT	267..316	CDD:214507	16/51 (31%)
		IG_like	328..428	CDD:214653	20/110 (18%)
		Ig	335..425	CDD:143165	18/100 (18%)
slt-1	NP_510437.2	LRRNT	17..47	CDD:214470	11/33 (33%)
		leucine-rich repeat	26..45	CDD:275380	6/18 (33%)
		LRR_RI	<48..195	CDD:238064	50/159 (31%)
		LRR_8	48..104	CDD:290566	20/57 (35%)
		leucine-rich repeat	48..69	CDD:275380	9/22 (41%)
		leucine-rich repeat	70..93	CDD:275380	5/22 (23%)
		LRR_8	94..152	CDD:290566	18/60 (30%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		leucine-rich repeat	118..165	CDD:275380	16/54 (30%)
		LRR_8	142..196	CDD:290566	19/61 (31%)
		leucine-rich repeat	142..163	CDD:275380	6/25 (24%)
		leucine-rich repeat	166..284	CDD:275380	31/125 (25%)
		LRRCT	195..243	CDD:214507	16/52 (31%)
		LRRNT	259..291	CDD:214470	3/31 (10%)
		leucine-rich repeat	285..312	CDD:275380	7/33 (21%)
		LRR_8	287..347	CDD:290566	13/72 (18%)
		LRR_4	311..352	CDD:289563	9/46 (20%)
		leucine-rich repeat	313..336	CDD:275380	2/22 (9%)
		LRR_8	336..419	CDD:290566	15/89 (17%)
		leucine-rich repeat	337..384	CDD:275380	10/50 (20%)
		leucine-rich repeat	385..408	CDD:275380	3/22 (14%)
		LRRCT	417..466	CDD:214507	8/48 (17%)
		LRRNT	484..512	CDD:214470	8/41 (20%)
		leucine-rich repeat	494..516	CDD:275380	4/29 (14%)
		LRR_RI	<514..635	CDD:238064	24/158 (15%)
		leucine-rich repeat	517..538	CDD:275380	2/20 (10%)
		LRR_8	538..597	CDD:290566	16/96 (17%)
		leucine-rich repeat	539..562	CDD:275380	4/22 (18%)
		leucine-rich repeat	563..586	CDD:275380	7/57 (12%)
		leucine-rich repeat	587..610	CDD:275380	7/25 (28%)
		leucine-rich repeat	611..675	CDD:275380	15/110 (14%)
		leucine-rich repeat	676..729	CDD:275380	16/60 (27%)
		LRRNT	677..708	CDD:214470	8/33 (24%)
		LRR_8	729..788	CDD:290566	7/58 (12%)
		LRR_4	729..771	CDD:289563	3/41 (7%)
		leucine-rich repeat	730..753	CDD:275380	1/22 (5%)
		leucine-rich repeat	754..777	CDD:275380	3/22 (14%)
		leucine-rich repeat	778..799	CDD:275380	7/36 (19%)
		EGF_CA	909..945	CDD:238011
		EGF_CA	947..983	CDD:238011
		EGF_CA	<994..1023	CDD:238011
		EGF_CA	1025..1061	CDD:238011
		LamG	1133..1268	CDD:214598
		CT	1334..1405	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I8404
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910