DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and DCN

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_001911.1 Gene:DCN / 1634 HGNCID:2705 Length:359 Species:Homo sapiens


Alignment Length:244 Identity:72/244 - (29%)
Similarity:105/244 - (43%) Gaps:40/244 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYL 143
            ||..|:|..:    .|.|.:..|..:|:.|...|.||||..|:|..|.|..|  ..|.||..:.|
Human    54 CPFRCQCHLR----VVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDF--KNLKNLHALIL 112

  Fly   144 ARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVP 208
            ....:..:...||..|:.|..|.||:|.|..:|...   ...|:|||...|.|.:|....|..:.
Human   113 VNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTFNGLN 174

  Fly   209 QLVKLEL--SDCRLSHIAVRAFAGLES--------------------SLEWLKLDGNRLSEVRSG 251
            |::.:||  :..:.|.|...||.|::.                    ||..|.||||::|.|.:.
Human   175 QMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239

  Fly   252 TITSLASLHGLELARNTW----NCSCSLRP-LRAWMLQQN----IPSGI 291
            ::..|.:|..|.|:.|:.    |.|.:..| ||...|..|    :|.|:
Human   240 SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 53/178 (30%)
leucine-rich repeat 112..137 CDD:275380 11/24 (46%)
LRR_8 137..196 CDD:290566 18/58 (31%)
leucine-rich repeat 138..161 CDD:275380 5/22 (23%)
leucine-rich repeat 162..185 CDD:275380 7/22 (32%)
LRR_8 184..245 CDD:290566 23/82 (28%)
leucine-rich repeat 186..209 CDD:275380 8/22 (36%)
leucine-rich repeat 210..234 CDD:275380 7/45 (16%)
leucine-rich repeat 235..258 CDD:275380 9/22 (41%)
LRRCT 267..316 CDD:214507 10/34 (29%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
DCNNP_001911.1 LRRNT 54..80 CDD:279764 8/29 (28%)
leucine-rich repeat 62..82 CDD:275380 5/23 (22%)
NEL <70..>298 CDD:330839 66/224 (29%)
LRR 1 73..93 8/19 (42%)
leucine-rich repeat 83..106 CDD:275380 11/24 (46%)
LRR 2 94..117 7/24 (29%)
leucine-rich repeat 107..130 CDD:275380 5/22 (23%)
LRR 3 118..141 8/22 (36%)
leucine-rich repeat 131..151 CDD:275380 7/22 (32%)
LRR 4 142..162 6/22 (27%)
leucine-rich repeat 152..175 CDD:275380 8/22 (36%)
LRR 5 163..186 5/22 (23%)
leucine-rich repeat 176..201 CDD:275380 7/24 (29%)
LRR 6 187..212 5/24 (21%)
leucine-rich repeat 202..222 CDD:275380 0/19 (0%)
LRR 7 213..233 7/19 (37%)
leucine-rich repeat 223..246 CDD:275380 9/22 (41%)
LRR 8 234..257 7/22 (32%)
leucine-rich repeat 247..270 CDD:275380 6/22 (27%)
LRR 9 258..281 7/22 (32%)
LRR 10 282..304 2/7 (29%)
leucine-rich repeat 294..313 CDD:275380
LRR 11 305..334
LRR 12 335..359
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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