DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and LGI4

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_644813.1 Gene:LGI4 / 163175 HGNCID:18712 Length:537 Species:Homo sapiens


Alignment Length:545 Identity:118/545 - (21%)
Similarity:160/545 - (29%) Gaps:210/545 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 RAECPAVCECKWKSGKESVLCLNANLTHIPQ-PLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQ 139
            :.:||..|.|    .|:|.||..:     |. |:.....||.||                     
Human    24 KGKCPLRCSC----SKDSALCEGS-----PDLPVSFSPTLLSLS--------------------- 58

  Fly   140 KVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAF 204
               |.|..:..::..:|.:                ||||.|        |..:.|....:.||||
Human    59 ---LVRTGVTQLKAGSFLR----------------IPSLHL--------LLFTSNSFSVIEDDAF 96

  Fly   205 GHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTW 269
            ..:..|..|.:.|..:..|:..|..||. ||..|.|..|.|..:.......|.:|..::|..|.:
Human    97 AGLSHLQYLFIEDNEIGSISKNALRGLR-SLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPF 160

  Fly   270 NCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRN 334
            .|.|.:..|..||...|...| ...|..|..||......||...|.|                |.
Human   161 QCDCRVLWLLQWMPTVNASVG-TGACAGPASLSHMQLHHLDPKTFKC----------------RA 208

  Fly   335 ITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTIL 399
            |.:|            |         ....|:.....||   .:.|| :.::|.....|....||
Human   209 IELS------------W---------FQTVGESALSVEP---FSYQG-EPHIVLAQPFAGRCLIL 248

  Fly   400 TADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGA---VAALLLVGGSSFAAI 461
            :.|.        :.:....:.|......||.:|         ::||.   |.|..|.|||     
Human   249 SWDY--------SLQRFRPEEELPAASVVSCKP---------LVLGPSLFVLAARLWGGS----- 291

  Fly   462 CLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYL 526
                       :||                    .||..|                        |
Human   292 -----------QLW--------------------ARPSPG------------------------L 301

  Fly   527 RAAHTP-------LNDNDA------GQAAAIVNPS--AGSAQR--RNGD--YLHVSTHC---DDE 569
            |.|.|.       |..|||      ||...:|..:  |||...  |:|.  |.|.|.|.   |.:
Human   302 RLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTD 366

  Fly   570 EEDQQLHHHP-------QQQPASQH 587
            .|..:|...|       .|:|...|
Human   367 AEALELDGRPHLLLASASQRPVLFH 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 34/156 (22%)
leucine-rich repeat 112..137 CDD:275380 4/24 (17%)
LRR_8 137..196 CDD:290566 10/58 (17%)
leucine-rich repeat 138..161 CDD:275380 3/22 (14%)
leucine-rich repeat 162..185 CDD:275380 5/22 (23%)
LRR_8 184..245 CDD:290566 18/60 (30%)
leucine-rich repeat 186..209 CDD:275380 6/22 (27%)
leucine-rich repeat 210..234 CDD:275380 7/23 (30%)
leucine-rich repeat 235..258 CDD:275380 6/22 (27%)
LRRCT 267..316 CDD:214507 15/48 (31%)
IG_like 328..428 CDD:214653 15/99 (15%)
Ig 335..425 CDD:143165 14/89 (16%)
LGI4NP_644813.1 leucine-rich repeat 29..53 CDD:275380 8/32 (25%)
LRR 1 53..74 7/44 (16%)
leucine-rich repeat 54..77 CDD:275378 8/62 (13%)
LRR_8 76..136 CDD:316378 22/68 (32%)
LRR 2 77..98 9/28 (32%)
leucine-rich repeat 78..101 CDD:275378 8/30 (27%)
LRR 3 101..122 5/20 (25%)
leucine-rich repeat 102..125 CDD:275378 7/23 (30%)
LRR 4 125..146 6/20 (30%)
leucine-rich repeat 126..149 CDD:275378 6/22 (27%)
PCC 131..>206 CDD:188093 21/75 (28%)
leucine-rich repeat 150..162 CDD:275378 3/11 (27%)
leucine-rich repeat 167..205 CDD:275380 11/38 (29%)
EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 210..252 11/66 (17%)
EPTP 214..251 CDD:309018 9/40 (23%)
EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 256..298 15/86 (17%)
EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 302..349 14/46 (30%)
EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 351..394 11/41 (27%)
EPTP 351..392 CDD:309018 11/41 (27%)
EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 396..439
EPTP 396..438 CDD:309018
EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 441..483
EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 487..532
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141333
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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