DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and LINGO2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001245211.1	Gene:	LINGO2 / 158038	HGNCID:	21207	Length:	606	Species:	Homo sapiens

Alignment Length:	539	Identity:	119/539 - (22%)
Similarity:	175/539 - (32%)	Gaps:	207/539 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LHLHLLLW---------LLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGT 112
            ||..:..|         |:...|.:|     |||.|||  .:..:||.|....|..||:.:...|
Human     2 LHTAISCWQPFLGLAVVLIFMGSTIG-----CPARCEC--SAQNKSVSCHRRRLIAIPEGIPIET 59

  Fly   113 QLLDLS------------------------------------------------GNEIQLIPDDS 129
            ::||||                                                ||.::|:|...
Human    60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGV 124

  Fly   130 F----------------------------------------------ATAQLLNLQKVYLARC-- 146
            |                                              |.:.||:|:::.|.:|
Human   125 FTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNL 189

  Fly   147 ---------HLR-LIERH------------AFRKL------------------------INLVEL 165
                     ||| ||..|            ||::|                        :||..|
Human   190 TAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSL 254

  Fly   166 DLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAG 230
            .::...||.:|.||..|:..|..|.||.|||..:....|..:.:|.:|.:...:|..|...:|.|
Human   255 SVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQG 319

  Fly   231 LESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPS----GI 291
            |. .|..|.:..|.|..:.....:|..:|..|.:..|...|.|.|    .|:||:. |:    |.
Human   320 LR-FLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRL----LWILQRQ-PTLQFGGQ 378

  Fly   292 PPTCESPPRLSGRAWDKLDVDD----FACVPQIVATDTTAHGV--EGRNITMSCYVEGVPQPAVK 350
            .|.|..|..:..|::.......    |.|....:......|.:  ||:.:.:.|..:|.|||.:.
Human   379 QPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVIS 443

  Fly   351 WLL-KNRLIANLSAG-----GDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIY 409
            |:. :.|.|...|.|     |||                           .|.|..|..||:|:|
Human   444 WVTPRRRFITTKSNGRATVLGDG---------------------------TLEIRFAQDQDSGMY 481

  Fly   410 TCAAENKAGKVEASVTLAV 428
            .|.|.|.||....:.:|.|
Human   482 VCIASNAAGNDTFTASLTV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	56/298 (19%)
		leucine-rich repeat	112..137	CDD:275380	12/118 (10%)
		LRR_8	137..196	CDD:290566	26/106 (25%)
		leucine-rich repeat	138..161	CDD:275380	12/70 (17%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	18/60 (30%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	14/56 (25%)
		IG_like	328..428	CDD:214653	29/107 (27%)
		Ig	335..425	CDD:143165	25/95 (26%)
LINGO2	NP_001245211.1	LRRNT	27..60	CDD:214470	13/39 (33%)
		leucine-rich repeat	39..57	CDD:275380	6/17 (35%)
		LRR 1	58..79		5/20 (25%)
		leucine-rich repeat	59..82	CDD:275380	5/22 (23%)
		LRR_8	60..117	CDD:316378	6/56 (11%)
		LRR 2	82..103		0/20 (0%)
		leucine-rich repeat	83..106	CDD:275380	0/22 (0%)
		LRR_8	106..165	CDD:316378	5/58 (9%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	5/22 (23%)
		LRR 4	130..151		0/20 (0%)
		leucine-rich repeat	131..154	CDD:275380	0/22 (0%)
		LRR_5	146..276	CDD:331043	24/129 (19%)
		LRR 5	154..175		1/20 (5%)
		leucine-rich repeat	155..178	CDD:275380	2/22 (9%)
		LRR 6	178..199		3/20 (15%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		LRR 7	202..223		5/20 (25%)
		leucine-rich repeat	203..250	CDD:275380	6/46 (13%)
		LRR 8	226..247		0/20 (0%)
		LRR_8	250..309	CDD:316378	19/58 (33%)
		LRR 9	250..271		8/20 (40%)
		leucine-rich repeat	251..274	CDD:275380	8/22 (36%)
		LRR 10	274..295		8/20 (40%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR_8	298..357	CDD:316378	15/59 (25%)
		LRR 11	298..319		5/20 (25%)
		leucine-rich repeat	299..322	CDD:275380	7/23 (30%)
		LRR 12	322..343		4/20 (20%)
		leucine-rich repeat	323..343	CDD:275380	4/19 (21%)
		PCC	327..>391	CDD:188093	17/68 (25%)
		I-set	410..500	CDD:254352	29/116 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910