DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and CHADL

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens

Alignment Length:	393	Identity:	96/393 - (24%)
Similarity:	136/393 - (34%)	Gaps:	135/393 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LEAPGPPSGQDIASDNSAQRRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQ 74
            |..||..:.:    :...:.|.:|      |||...| .||..|                   |:
Human   423 LRCPGDAAQE----EEELEERAVA------GPRAPPR-GPPRGP-------------------GE 457

  Fly    75 LR--AECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLN 137
            .|  |.||..|.|..:|...|  |....|..:|:...:.||||||..|....:|..:|  ..|.:
Human   458 ERAVAPCPRACVCVPESRHSS--CEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAF--PGLGH 518

  Fly   138 LQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLS----------------------------- 173
            |..::|..|.:..:|..|...|..|:.|.||.|.|:
Human   519 LVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 583

  Fly   174 ---AIPSLALYHVSE----------------LRELRLSGNPILRVPDDAFGHVPQLVKLELSDCR 219
               |:|||...|:.:                ||.:.||||.|..|...|.|...:|.||.|...:
Human   584 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQ 648

  Fly   220 LSHIAVRAFAGLESSLEWLKLDGNRLSEVRSG--------------------------------- 251
            |..:...|..||.:.|| |:|.||.|..:|.|
Human   649 LREVPTGALEGLPALLE-LQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPG 712

  Fly   252 ---------------TITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRL 301
                           .:.||:.|..::|:.|.::|.|.|.||..|:...|:..|  .||.:||..
Human   713 LQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG--ATCATPPNA 775

  Fly   302 SGR 304
            .|:
Human   776 RGQ 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	58/252 (23%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	23/106 (22%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	11/54 (20%)
		LRR_8	184..245	CDD:290566	24/76 (32%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	11/70 (16%)
		LRRCT	267..316	CDD:214507	14/38 (37%)
		IG_like	328..428	CDD:214653
		Ig	335..425	CDD:143165
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380
		LRR_RI	<133..358	CDD:238064
		LRR_8	133..214	CDD:290566
		leucine-rich repeat	156..179	CDD:275380
		leucine-rich repeat	180..203	CDD:275380
		leucine-rich repeat	204..227	CDD:275380
		LRR_8	228..286	CDD:290566
		leucine-rich repeat	228..251	CDD:275380
		leucine-rich repeat	252..275	CDD:275380
		leucine-rich repeat	276..299	CDD:275380
		leucine-rich repeat	300..323	CDD:275380
		LRR_8	322..380	CDD:290566
		leucine-rich repeat	324..347	CDD:275380
		LRR_4	346..>380	CDD:289563
		LRRNT	463..497	CDD:214470	10/35 (29%)
		leucine-rich repeat	478..494	CDD:275380	4/17 (24%)
		LRR_RI	492..671	CDD:238064	49/181 (27%)
		leucine-rich repeat	495..518	CDD:275380	10/24 (42%)
		LRR_8	518..577	CDD:290566	12/58 (21%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..566	CDD:275380	6/22 (27%)
		LRR_8	565..625	CDD:290566	11/59 (19%)
		leucine-rich repeat	567..590	CDD:275380	1/22 (5%)
		leucine-rich repeat	591..614	CDD:275380	2/22 (9%)
		leucine-rich repeat	615..638	CDD:275380	10/22 (45%)
		LRR_8	637..698	CDD:290566	17/61 (28%)
		leucine-rich repeat	639..662	CDD:275380	8/22 (36%)
		leucine-rich repeat	663..687	CDD:275380	9/24 (38%)
		LRR_8	686..745	CDD:290566	5/58 (9%)
		leucine-rich repeat	688..712	CDD:275380	0/23 (0%)
		LRR_4	711..>744	CDD:289563	4/32 (13%)
		LRRCT	743..791	CDD:214507	14/38 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840