DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LRFN5

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001333102.1	Gene:	LRFN5 / 145581	HGNCID:	20360	Length:	719	Species:	Homo sapiens

Alignment Length:	807	Identity:	173/807 - (21%)
Similarity:	271/807 - (33%)	Gaps:	223/807 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYL 143
            ||..|.|:..|...:.||....|..:|..:|..|..|.|:.|.:..|....|  |.:.:|..:.|
Human    20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDF--ANMTSLVDLTL 82

  Fly   144 ARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVP 208
            :|..:..|..|||..|.||..|.|:.|.|:.|.:.....:|.|..|.|:.|.:..:...||..|.
Human    83 SRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF 147

  Fly   209 QLVKLELSDCRLSHI---AVRAFAGLESSLEWLKLDGNRLSEVRSGTITSL-------------- 256
            .|.:|:||...|..|   ||....    ||..|.||.|.:..:..||.:.|
Human   148 ALEELDLSYNNLETIPWDAVEKMV----SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQ 208

  Fly   257 ---------------------ASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPR 300
                                 .|...|....|..:|:|.|..||....:.::     .||.|||.
Human   209 KLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDL-----ETCASPPL 268

  Fly   301 LSGRAWDKLDVDDFACVPQIVATDTTAHGV-EGRNITMSCYVEGVPQPAVKWLL-KNRLIANLSA 363
            |:||.:..:..::|.|.|.::...|....| ||:..|:.|...|.|:||:.|:. :.:||:|
Human   269 LTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISN--- 330

  Fly   364 GGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAV 428
                          ||:       :::.:...|.||...::|.|.:||.|.|.||:....|.|.:
Human   331 --------------ATR-------SLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI 374

  Fly   429 SRRP---------PEAPWGVRIILLGAVAA----------------LLLVGGSSFAAICLCSLQR 468
            .:.|         .|...|...|.....:.                :::...:|..|:...:.||
Human   375 IKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQR 439

  Fly   469 R----RKLRL-----------WNSVPPVRRSESYEKIEMTARTRPDLGGGASC-------GGGSA 511
            .    |..::           :..:||.  |:::....:.|.|..||     |       |..|.
Human   440 NIPGIRMFQIQYNGTYDDTLVYRMIPPT--SKTFLVNNLAAGTMYDL-----CVLAIYDDGITSL 497

  Fly   512 TG---AGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVST--------- 564
            |.   .|......||.|:| .|...:....|....|:           |..:..|.
Human   498 TATRVVGCIQFTTEQDYVR-CHFMQSQFLGGTMIIII-----------GGIIVASVLVFIIILMI 550

  Fly   565 ---HCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIP 626
               .|:                        |..||:..|     |.:.....|.|.::...:.:|
Human   551 RYKVCN------------------------NNGQHKVTK-----VSNVYSQTNGAQIQGCSVTLP 586

  Fly   627 RLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATP 691
            :            |:|.|.         .||.........|..|...|....|:..||..|.|.|
Human   587 Q------------SVSKQA---------VGHEENAQCCKATSDNVIQSSETCSSQDSSTTTSALP 630

  Fly   692 YAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGL 756
                   |:...:|||...:.:::....|..|.     ..||...:.:...:..:.|..     |
Human   631 -------PSWTSSTSVSQKQKRKTGTKPSTEPQ-----NEAVTNVESQNTNRNNSTALQ-----L 678

  Fly   757 CTLPRKLKTSGKYFRNSSDSQSPLLAD 783
            .:.|....|.|...:.:....:.||.:
Human   679 ASRPPDSVTEGPTSKRAHIKPNALLTN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	49/194 (25%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	20/58 (34%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	22/63 (35%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	8/26 (31%)
		leucine-rich repeat	235..258	CDD:275380	8/57 (14%)
		LRRCT	267..316	CDD:214507	15/48 (31%)
		IG_like	328..428	CDD:214653	28/101 (28%)
		Ig	335..425	CDD:143165	23/90 (26%)
LRFN5	NP_001333102.1	LRR 1	52..73		6/22 (27%)
		LRR 2	76..97		7/20 (35%)
		LRR 3	100..121		7/20 (35%)
		LRR 4	124..145		6/20 (30%)
		LRR 5	148..169		8/20 (40%)
		LRR 6	172..193		8/20 (40%)
		LRR 7	196..217		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..414		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..694		19/95 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960