DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lgr5

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	223	Identity:	73/223 - (32%)
Similarity:	104/223 - (46%)	Gaps:	33/223 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQLGQLRAE------------CPAVCECKWKSGKE--SVLCLNANLTHIPQPLD 109
            :|:||.||.    |.||.|.            ||:.|.|: ..|:.  .|.|.:..|:.:|..|.
Mouse     6 VHMLLSLLA----LLQLVAAGSSPGPDAIPRGCPSHCHCE-LDGRMLLRVDCSDLGLSELPSNLS 65

  Fly   110 AGTQLLDLSGNEIQLIPDDSFATAQLLN----LQKVYLARCHLRLIERHAFRKLINLVELDLSQN 170
            ..|..||||.|.|..:|      |.||:    |:::.||...|..|.:.||..|.:|..|.|..|
Mouse    66 VFTSYLDLSMNNISQLP------ASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNN 124

  Fly   171 LLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSL 235
            .|..:|..||.::..|:.|||..|.|..||...|..:..|..|.|.|..|:.:.|:||..| |:|
Mouse   125 QLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSL-SAL 188

  Fly   236 EWLKLDGNRLSEVRS---GTITSLASLH 260
            :.:.|..|::..:..   |.::||..||
Mouse   189 QAMTLALNKIHHIADYAFGNLSSLVVLH 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	54/158 (34%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	21/62 (34%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	22/60 (37%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	6/25 (24%)
		LRRCT	267..316	CDD:214507
		IG_like	328..428	CDD:214653
		Ig	335..425	CDD:143165
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470	11/37 (30%)
		leucine-rich repeat	68..91	CDD:275380	11/28 (39%)
		LRR_RI	88..386	CDD:238064	43/130 (33%)
		LRR_8	92..150	CDD:290566	21/57 (37%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	8/22 (36%)
		LRR_8	138..198	CDD:290566	22/60 (37%)
		leucine-rich repeat	140..163	CDD:275380	9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	9/23 (39%)
		LRR_8	188..246	CDD:290566	8/29 (28%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	3/5 (60%)
		leucine-rich repeat	236..258	CDD:275380
		LRR_8	257..314	CDD:290566
		leucine-rich repeat	259..282	CDD:275380
		leucine-rich repeat	283..304	CDD:275380
		LRR_8	352..410	CDD:290566
		leucine-rich repeat	354..375	CDD:275378
		leucine-rich repeat	376..389	CDD:275378
		leucine-rich repeat	400..423	CDD:275378
		leucine-rich repeat	445..467	CDD:275378
		7tm_1	575..820	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930