DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and TOLL7

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_320221.4	Gene:	TOLL7 / 1280374	VectorBaseID:	AGAP012326	Length:	1268	Species:	Anopheles gambiae

Alignment Length:	716	Identity:	149/716 - (20%)
Similarity:	216/716 - (30%)	Gaps:	246/716 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 APGPPS-----------GQDIASDNSAQ-RRTLATKVRRKGPR-----------PQRRLHPPLRP 53
            ||.||:           |.....|.|.: .:.:.....|:.|:           |..| ..|:||
Mosquito   620 APAPPTTERPLPEFYLGGNPFECDCSMEWMQRVNNLTTRQHPKIMDLPNVECIMPHAR-GSPIRP 683

  Fly    54 RLPL---------HLHLLLWLLCCCSQLGQLRAECPAVCEC----KWKSGKESVLCLNANLTHI- 104
            .:.|         ..|......||..........||:.|.|    .|  |...|.|.|......
Mosquito   684 IVSLQPKDFLCRYETHCFALCHCCDFDACDCEMTCPSNCTCYHDQTW--GTNVVDCGNQGAAAAA 746

  Fly   105 -----PQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVE 164
                 |.|:||....||  ||:|..:....|...:  ||:.:|.....:..|:...|..|..|..
Mosquito   747 AGGLRPVPMDATEVYLD--GNDIPELQHHVFIGRK--NLKVLYANASRIATIQNRTFAGLTALQA 807

  Fly   165 LDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFA 229
            |.|..|.|..|......:::.||||.|..|                        .|..||..:||
Mosquito   808 LHLEDNALQRIHGYEFENLALLRELYLQNN------------------------GLQSIANGSFA 848

  Fly   230 GLESSLEWLKLDGNRL-------SEVRSGTITSLASLHGLELARNTWNCSCSLRP-LRAWMLQQN 286
            .| .||..|:||||||       .:...|   :|.:|..|.|.||.|:|.|...| |.|::
Mosquito   849 PL-YSLRVLRLDGNRLVTMPLFQLQAAQG---NLQALQSLSLGRNPWSCRCRFLPELTAFV---- 905

  Fly   287 IPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQ-IVATDTTAHGVEGRNITMSC---YV------ 341
                              |.:.:.|.|    || :...|...|.....|::.:|   |.
Mosquito   906 ------------------ADNAVIVQD----PQDVYCADDGVHRELDFNVSAACSDFYAGRSVLP 948

  Fly   342 -EGVP---------------------------QPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAA 378
             :|:|                           :|...||...   ..:...|....|||
Mosquito   949 GDGLPETYIMLMALAVVLVCLLLLAVLMFVFREPLRFWLFSR---YGVRVFGPRCEDSE------ 1004

  Fly   379 TQGRKTYVVNMLRNASNLTILTADMQDAG--------IYTCAAEN------------KAGKVEAS 423
                |.|...:|.:|.:..::...:  ||        :..|....            :|.:....
Mosquito  1005 ----KLYDAILLYSAKDAELVARSI--AGELENGRPPLRLCLQHRDLPEDASHLQLLEASRASRR 1063

  Fly   424 VTLAVSRRPPEAPW-------GVRIILLGAVAALLLV--GGS------------SFAAICLCSLQ 467
            :.:.:||...:..|       .|...|.|....|::|  ||.            .:......:..
Mosquito  1064 IVVLLSRNFLQTEWSRCELRRAVHDALRGRPHKLVVVEEGGGVLLEAENDVELVPYLKTTTVTRV 1128

  Fly   468 RRRKLRLWNSVP---PVR---RSESY-----EKIEMTARTRPDLGGGASCGGGSATGAGLFHDAE 521
            ||.....|..:.   ||.   |..:|     |:::.|..     |||...||..|.|. :|....
Mosquito  1129 RRGDRHFWEKLRYALPVEAPYRGNNYTIDHHERVKQTGG-----GGGGGAGGQGAAGV-MFRQPP 1187

  Fly   522 EQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQ 586
            ...|     .|..|.....:|....||...::|                   .:...|.|:|.|:
Mosquito  1188 PPAY-----CPEIDEANYSSATTATPSPRPSRR-------------------GMVEVPTQRPPSE 1228

  Fly   587 H 587
            |
Mosquito  1229 H 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	45/163 (28%)
		leucine-rich repeat	112..137	CDD:275380	6/24 (25%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	19/60 (32%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	10/29 (34%)
		LRRCT	267..316	CDD:214507	10/49 (20%)
		IG_like	328..428	CDD:214653	21/156 (13%)
		Ig	335..425	CDD:143165	19/146 (13%)
TOLL7	XP_320221.4	leucine-rich repeat	61..84	CDD:275380
		LRR_8	63..126	CDD:290566
		leucine-rich repeat	85..115	CDD:275380
		LRR_RI	114..328	CDD:238064
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..204	CDD:290566
		leucine-rich repeat	169..193	CDD:275380
		LRR_8	192..252	CDD:290566
		leucine-rich repeat	194..217	CDD:275380
		leucine-rich repeat	218..241	CDD:275380
		LRR_8	242..302	CDD:290566
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..291	CDD:275380
		LRR_8	291..350	CDD:290566
		leucine-rich repeat	292..315	CDD:275380
		LRR_RI	302..587	CDD:238064
		leucine-rich repeat	316..339	CDD:275380
		LRR_8	339..398	CDD:290566
		leucine-rich repeat	340..363	CDD:275380
		leucine-rich repeat	364..387	CDD:275380
		LRR_8	388..445	CDD:290566
		LRR_4	388..426	CDD:289563
		leucine-rich repeat	411..434	CDD:275380
		leucine-rich repeat	435..458	CDD:275380
		LRR_8	457..516	CDD:290566
		leucine-rich repeat	459..482	CDD:275380
		leucine-rich repeat	483..503	CDD:275380
		leucine-rich repeat	575..598	CDD:275378
		TPKR_C2	638..694	CDD:301599	10/56 (18%)
		leucine-rich repeat	758..780	CDD:275380	6/25 (24%)
		LRR_8	779..839	CDD:290566	18/85 (21%)
		leucine-rich repeat	781..804	CDD:275380	5/22 (23%)
		LRR_RI	804..>889	CDD:238064	32/112 (29%)
		leucine-rich repeat	805..828	CDD:275380	6/22 (27%)
		LRR_8	829..890	CDD:290566	27/88 (31%)
		leucine-rich repeat	829..852	CDD:275380	12/47 (26%)
		leucine-rich repeat	853..880	CDD:275380	10/29 (34%)
		TIR	1007..1146	CDD:214587	21/140 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910