DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and AgaP_AGAP009138

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_319900.4	Gene:	AgaP_AGAP009138 / 1280097	VectorBaseID:	AGAP009138	Length:	289	Species:	Anopheles gambiae

Alignment Length:	282	Identity:	114/282 - (40%)
Similarity:	161/282 - (57%)	Gaps:	22/282 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CPA-VCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVY 142
            ||| ||.||||.||::|.|....|..:|..:|.|||:|:.|||.:.::..:.|...:|:||||:|
Mosquito    28 CPAEVCVCKWKGGKQTVECGGRFLNRLPDGMDPGTQVLNFSGNSLTILQSERFRKMELINLQKIY 92

  Fly   143 LARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHV 207
            |||..|..|...|||.|.||||||||.|.||.:|:......:.|..|.||||||..:...||..:
Mosquito    93 LARNQLVKIHDRAFRGLTNLVELDLSDNTLSEVPTETFQDYAALMRLSLSGNPIRALRASAFKQL 157

  Fly   208 PQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCS 272
            ..|..||||:|::..:...||.|:: :||||:|||||::.:|...:.. .||||:.|..|.|:|.
Mosquito   158 SYLTTLELSNCQIELVEDEAFIGMD-NLEWLRLDGNRIATIRGAHVLP-ESLHGINLQSNRWHCD 220

  Fly   273 CSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGV-EGRNIT 336
            |.|                 ..|..|.||:|.....|.:||.||:| :|..:|:...: |||||:
Mosquito   221 CHL-----------------TDCSGPARLAGETVKTLTLDDLACLP-VVTPETSYREIAEGRNIS 267

  Fly   337 MSCYVEGVPQPAVKWLLKNRLI 358
            :.|.:...|:|.|.||.:.:::
Mosquito   268 LDCRIVATPEPTVAWLFQGQVL 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	69/156 (44%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	32/58 (55%)
		leucine-rich repeat	138..161	CDD:275380	13/22 (59%)
		leucine-rich repeat	162..185	CDD:275380	11/22 (50%)
		LRR_8	184..245	CDD:290566	27/60 (45%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	10/22 (45%)
		LRRCT	267..316	CDD:214507	13/48 (27%)
		IG_like	328..428	CDD:214653	11/32 (34%)
		Ig	335..425	CDD:143165	7/24 (29%)
AgaP_AGAP009138	XP_319900.4	leucine-rich repeat	42..60	CDD:275380	4/17 (24%)
		leucine-rich repeat	62..87	CDD:275380	8/24 (33%)
		LRR_8	87..146	CDD:290566	32/58 (55%)
		LRR_RI	<88..209	CDD:238064	56/122 (46%)
		leucine-rich repeat	88..111	CDD:275380	13/22 (59%)
		leucine-rich repeat	112..135	CDD:275380	11/22 (50%)
		LRR_8	136..194	CDD:290566	27/58 (47%)
		leucine-rich repeat	136..159	CDD:275380	10/22 (45%)
		leucine-rich repeat	160..183	CDD:275380	9/23 (39%)
		leucine-rich repeat	184..206	CDD:275380	10/22 (45%)
		Ig	262..>289	CDD:299845	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23311at33392
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920