DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and AgaP_AGAP004832

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_314362.4	Gene:	AgaP_AGAP004832 / 1275133	VectorBaseID:	AGAP004832	Length:	1036	Species:	Anopheles gambiae

Alignment Length:	320	Identity:	81/320 - (25%)
Similarity:	129/320 - (40%)	Gaps:	77/320 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KESVLCLNA------------NLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYL 143
            :||:..|.|            ||.|:        ::|:|.||::..:....|..:.  |:..:.|
Mosquito   455 QESIESLEAKANLLSNIEFMKNLKHL--------KILNLEGNQVSELLGGEFNGSS--NITHLML 509

  Fly   144 ARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVP 208
            |..||..:...:|:.||||..|:||.|.::.|.......:..|.||.|:||.|..:|:|.|....
Mosquito   510 AYNHLHRLSNESFQGLINLKVLNLSNNTINYIGPDTFVGIRTLHELYLNGNDINSLPEDVFVSQE 574

  Fly   209 QLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEV------RSGTITSLASLHGLELAR- 266
            .|.||.|.|..|..|:||....| ..|:.|.|..|.::.:      |:..:..| ||:.:.|.|
Mosquito   575 ALEKLSLRDNGLEKISVRIIQNL-PRLKHLDLSNNPIANIPDQFLQRNMNLERL-SLNEVRLQRL 637

  Fly   267 --------------NTWNCS-CSLRPLRAWM----------LQQN----IPSGIPPTCE--SPPR 300
                          :...|| ..:.|...|:          |::|    :|.|:..|..  |...
Mosquito   638 SKKFIPEPKLMKYISLERCSIVEIEPEAFWLFGSVYSSEVYLRENELTILPKGLFRTSRMLSVLD 702

  Fly   301 LSGRAWDKLDVDDFAC-------------VPQIVATDTTA-HGVEGRNITMSCYVEGVPQ 346
            ||......|:.|.||.             :.|:.|.|... |.::..|:..:| :|.:|:
Mosquito   703 LSFNRLTHLNPDTFASDSSLHELYLEGNNIRQLAAGDLAIFHSLKILNLRNNC-IEWIPE 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	50/177 (28%)
		leucine-rich repeat	112..137	CDD:275380	5/24 (21%)
		LRR_8	137..196	CDD:290566	21/58 (36%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	24/60 (40%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	10/23 (43%)
		leucine-rich repeat	235..258	CDD:275380	6/28 (21%)
		LRRCT	267..316	CDD:214507	15/65 (23%)
		IG_like	328..428	CDD:214653	5/19 (26%)
		Ig	335..425	CDD:143165	3/12 (25%)
AgaP_AGAP004832	XP_314362.4	leucine-rich repeat	98..121	CDD:275380
		leucine-rich repeat	122..145	CDD:275380
		leucine-rich repeat	146..169	CDD:275380
		LRR_8	171..228	CDD:290566
		leucine-rich repeat	171..193	CDD:275380
		leucine-rich repeat	194..217	CDD:275380
		LRR_RI	<203..360	CDD:238064
		LRR_8	218..276	CDD:290566
		leucine-rich repeat	218..241	CDD:275380
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..312	CDD:275380
		LRR_8	312..371	CDD:290566
		leucine-rich repeat	313..336	CDD:275380
		leucine-rich repeat	337..360	CDD:275380
		leucine-rich repeat	361..382	CDD:275380
		leucine-rich repeat	383..408	CDD:275380
		LRR_8	384..443	CDD:290566
		leucine-rich repeat	409..432	CDD:275380
		leucine-rich repeat	433..479	CDD:275380	6/23 (26%)
		leucine-rich repeat	480..503	CDD:275380	5/32 (16%)
		LRR_RI	<484..608	CDD:238064	42/126 (33%)
		LRR_8	502..562	CDD:290566	21/61 (34%)
		leucine-rich repeat	504..527	CDD:275380	6/22 (27%)
		leucine-rich repeat	528..551	CDD:275380	6/22 (27%)
		LRR_8	550..610	CDD:290566	24/60 (40%)
		leucine-rich repeat	552..575	CDD:275380	10/22 (45%)
		LRR_RI	554..>799	CDD:238064	53/211 (25%)
		leucine-rich repeat	576..599	CDD:275380	10/23 (43%)
		leucine-rich repeat	600..623	CDD:275380	5/22 (23%)
		leucine-rich repeat	624..697	CDD:275380	14/73 (19%)
		leucine-rich repeat	649..671	CDD:275380	4/21 (19%)
		LRR_8	698..754	CDD:290566	12/55 (22%)
		leucine-rich repeat	698..721	CDD:275380	7/22 (32%)
		LRR_RI	722..1036	CDD:238064	8/41 (20%)
		leucine-rich repeat	722..745	CDD:275380	3/22 (14%)
		LRR_8	745..801	CDD:290566	4/18 (22%)
		leucine-rich repeat	746..769	CDD:275380	4/17 (24%)
		leucine-rich repeat	770..793	CDD:275380
		leucine-rich repeat	794..817	CDD:275380
		leucine-rich repeat	818..838	CDD:275380
		leucine-rich repeat	842..866	CDD:275380
		leucine-rich repeat	886..908	CDD:275380
		leucine-rich repeat	931..957	CDD:275378
		LRR_8	978..1035	CDD:290566
		leucine-rich repeat	980..1003	CDD:275378
		leucine-rich repeat	1004..1017	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910