DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Chad

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_031715.1	Gene:	Chad / 12643	MGIID:	1096866	Length:	358	Species:	Mus musculus

Alignment Length:	341	Identity:	84/341 - (24%)
Similarity:	130/341 - (38%)	Gaps:	109/341 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIP 126
            ||:.|...:.|....|.||..|.|  ....:.|:|....|..||: :...|:||:|..|...::.
Mouse     5 LLFSLVFLAILLPALAACPQNCHC--HGDLQHVICDKVGLQKIPK-VSETTKLLNLQRNNFPVLA 66

  Fly   127 DDSFATAQLLNLQKVYLARCHLRLIERHAFR---KLI---------------------------- 160
            .:||.|  :.||..::|..|::|.:...|||   :||
Mouse    67 ANSFRT--MPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYL 129

  Fly   161 ----------------------------------------------------------------- 160

Mouse   130 DHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVE 194

  Fly   161 NLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQ-LVKLELSDCRLSHIA 224
            ||.:..|.:|.||:.||.||..:..:.||:||.||:..:||:||....: |..|.|.:..|...:
Mouse   195 NLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFS 259

  Fly   225 VRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM-LQQNIP 288
            ..||:|: ::|:.:.||.|||:::.|.  ....:|..|.|..|.|.|:|.||.||.|: .:.:.|
Mouse   260 DAAFSGV-TTLKHVHLDNNRLNQLPSS--FPFDNLETLTLTNNPWKCTCQLRGLRRWLEAKASRP 321

  Fly   289 SGIPPTCESPPRLSGR 304
            ..   ||.||.:..|:
Mouse   322 DA---TCSSPAKFKGQ 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	55/253 (22%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	25/154 (16%)
		leucine-rich repeat	138..161	CDD:275380	9/118 (8%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	21/61 (34%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	267..316	CDD:214507	15/39 (38%)
		IG_like	328..428	CDD:214653
		Ig	335..425	CDD:143165
Chad	NP_031715.1	LRRNT	22..48	CDD:279764	9/28 (32%)
		LRR 1	51..72		7/20 (35%)
		leucine-rich repeat	52..75	CDD:275380	8/24 (33%)
		LRR_8	74..134	CDD:290566	10/59 (17%)
		LRR 2	75..96		7/20 (35%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		LRR_RI	<89..281	CDD:238064	38/192 (20%)
		LRR 3	99..120		2/20 (10%)
		leucine-rich repeat	100..123	CDD:275380	2/22 (9%)
		LRR 4	123..144		0/20 (0%)
		leucine-rich repeat	124..147	CDD:275380	0/22 (0%)
		LRR_8	147..206	CDD:290566	4/58 (7%)
		LRR 5	147..168		0/20 (0%)
		leucine-rich repeat	148..171	CDD:275380	0/22 (0%)
		LRR 6	171..192		0/20 (0%)
		leucine-rich repeat	172..195	CDD:275380	0/22 (0%)
		LRR 7	195..216		10/20 (50%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		LRR 8	219..240		10/20 (50%)
		LRR_8	220..279	CDD:290566	21/59 (36%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		LRR 9	244..265		6/20 (30%)
		leucine-rich repeat	245..268	CDD:275380	7/23 (30%)
		LRR 10	268..289		7/22 (32%)
		leucine-rich repeat	269..291	CDD:275380	7/23 (30%)
		LRRCT	299..346	CDD:214507	15/39 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..358		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840