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Protein Alignment kek3 and LRIG3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_700356.2	Gene:	LRIG3 / 121227	HGNCID:	30991	Length:	1119	Species:	Homo sapiens

Alignment Length:	997	Identity:	212/997 - (21%)
Similarity:	323/997 - (32%)	Gaps:	295/997 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 WKSGKESVLCL-NANLTHIPQPLDAG---TQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCH 147
            |......:|.| :.|||.|.:....|   .|.|.||.|.|..|..|::...|  .|.::.|...|
Human   260 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ--KLSELDLTFNH 322

  Fly   148 LRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDD---AFGHVPQ 209
            |..::..:|..|..|..|.:..|.:|.|...|...:|.|:.|.|..|.|....:|   ||..:.:
Human   323 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDK 387

  Fly   210 LVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCS 274
            |.:|.|...|:..|..:||.||: :||.|.|..|.:..::....:.:..|..|.|..::..|.|.
Human   388 LRRLILQGNRIRSITKKAFTGLD-ALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQ 451

  Fly   275 LRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC----VPQIVATDTTAHGVEGRNI 335
            |:.|..|:.:.|..|.:..:|..|..|.||:...:..|.|.|    .|||.....|...::|.|:
Human   452 LKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNL 516

  Fly   336 TMSCYVEGVPQPAV--KWLLKNRLI--------ANLSAGGDGD----------------SDSEPR 374
            :..|.........:  .|...|.|:        |:|.|.| |:                |:.:.:
Human   517 SFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG-GEVMEYTTILRLREVEFASEGKYQ 580

  Fly   375 TAAATQGRKTY------VVNML----RNASNLTILTADM-------------------------- 403
            ...:.....:|      .||||    :...:|||....|
Human   581 CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP 645

  Fly   404 -----------------------QDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAPWGVRIILL 444
                                   :|.|:|:|.|:|.||.:.|:.||.|...|. ..|...|.:..
Human   646 AARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 710

  Fly   445 GAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGG------ 503
            |..|.|..:.|.|                     ||.:.:.:.:...:....|.....|
Human   711 GETAVLQCIAGGS---------------------PPPKLNWTKDDSPLVVTERHFFAAGNQLLII 754

  Fly   504 ----------ASCGGGSATGAGLFHDAEEQGYLRAA--HTPLND---------NDAGQAA----- 542
                      .:|...:..|.       |:|.:|.:  .||..|         :|.|.|.
Human   755 VDSDVSDAGKYTCEMSNTLGT-------ERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVI 812

  Fly   543 -AIVNPSAGSA----------QRRNGDYLHVSTHCDDEEEDQQLHHHPQQQP---ASQHHPHPNQ 593
             |:|....|::          :|||.|       |.....|:.  :.|...|   :||......|
Human   813 IAVVCCVVGTSLVWVVIIYHTRRRNED-------CSITNTDET--NLPADIPSYLSSQGTLADRQ 868

  Fly   594 QQH-QQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAAR--LAGYA 655
            ..: ....||....|::|||....|..          |..||....:|..:.|:||..  |..:.
Human   869 DGYVSSESGSHHQFVTSSGAGFFLPQH----------DSSGTCHIDNSSEADVEAATDLFLCPFL 923

  Fly   656 GHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESDLFDS 720
            |                      |..|..|....     ||:.|.:...|.  ||....:.|.|.
Human   924 G----------------------STGPMYLKGNV-----YGSDPFETYHTG--CSPDPRTVLMDH 959

  Fly   721 NYPDLLDIAK-YAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPLLADN 784
            ..|..:...: |..:...:|...:.::..:...:     :.:.|.||  |..|.......|..:.
Human   960 YEPSYIKKKECYPCSHPSEESCERSFSNISWPSH-----VRKLLNTS--YSHNEGPGMKNLCLNK 1017

  Fly   785 SSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGKLLP 849
            ||                    ..:||....|:.:|          :|||:     |.....|..
Human  1018 SS--------------------LDFSANPEPASVAS----------SNSFM-----GTFGKALRR 1047

  Fly   850 SHLGQKPSL--PSSPVQHQRSLSSAATPLLDFSALASRAAGAANTSVAAYDYHAAQLERFLEEYR 912
            .||....|.  ||........|.:.::|.||   ..|...|...|.             |.||
Human  1048 PHLDAYSSFGQPSDCQPRAFYLKAHSSPDLD---SGSEEDGKERTD-------------FQEE-- 1094

  Fly   913 NLQDQLCKMKETCDTIRKKETP 934
               :.:|..|:|.:..|   ||
Human  1095 ---NHICTFKQTLENYR---TP 1110

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.