DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and LRG1

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_443204.1 Gene:LRG1 / 116844 HGNCID:29480 Length:347 Species:Homo sapiens


Alignment Length:340 Identity:87/340 - (25%)
Similarity:119/340 - (35%) Gaps:96/340 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 RPRLP--LHLH----LLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLC---------LNA-- 99
            ||:.|  :..|    |.|.||...|..|...:  |..|:........|:.|         |.|  
Human     8 RPKSPGGIQPHVSRTLFLLLLLAASAWGVTLS--PKDCQVFRSDHGSSISCQPPAEIPGYLPADT 70

  Fly   100 --------NLTHIPQPLDAGT---------------------------QLLDLSGNEIQLIPDDS 129
                    ||||:|..|..|.                           ::|||:.|.:..:|...
Human    71 VHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGL 135

  Fly   130 F---ATAQLLNLQKVYL------------ARCHLRLIERHAFRKL--------INLVELDLSQNL 171
            |   ||...|.|::..|            |..||.| ..:..|||        ..|..|||.:|.
Human   136 FQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDL-SGNRLRKLPPGLLANFTLLRTLDLGENQ 199

  Fly   172 LSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLE 236
            |..:|...|....:|..|.|.||.:..:..|.....|.|..|.|:..:|:.:|..||.||. .|:
Human   200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLR-QLD 263

  Fly   237 WLKLDGNRLSEVRSGTITSLASLH-----GLELARNTWNCSCSLRPLRAW-------MLQQNIPS 289
            .|.|..|.|:.|..|...||...:     |.:::.|.|.|..:|..|..|       |..||   
Human   264 MLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQN--- 325

  Fly   290 GIPPTCESPPRLSGR 304
              ...|..|..:.|:
Human   326 --DTRCAGPEAVKGQ 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 53/211 (25%)
leucine-rich repeat 112..137 CDD:275380 8/54 (15%)
LRR_8 137..196 CDD:290566 22/78 (28%)
leucine-rich repeat 138..161 CDD:275380 9/42 (21%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 20/60 (33%)
leucine-rich repeat 186..209 CDD:275380 6/22 (27%)
leucine-rich repeat 210..234 CDD:275380 9/23 (39%)
leucine-rich repeat 235..258 CDD:275380 9/22 (41%)
LRRCT 267..316 CDD:214507 12/45 (27%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
LRG1NP_443204.1 LRR_8 79..128 CDD:290566 11/48 (23%)
LRR_RI <82..248 CDD:238064 40/166 (24%)
LRR 1 93..114 0/20 (0%)
leucine-rich repeat 94..117 CDD:275380 0/22 (0%)
LRR_8 116..176 CDD:290566 15/60 (25%)
LRR 2 117..138 6/20 (30%)
leucine-rich repeat 118..141 CDD:275380 6/22 (27%)
LRR 3 141..162 4/20 (20%)
leucine-rich repeat 142..165 CDD:275380 3/22 (14%)
LRR 4 165..186 7/21 (33%)
leucine-rich repeat 166..189 CDD:275380 6/23 (26%)
LRR_8 169..224 CDD:290566 18/55 (33%)
LRR 5 189..210 8/20 (40%)
leucine-rich repeat 190..213 CDD:275380 8/22 (36%)
LRR_8 213..272 CDD:290566 20/59 (34%)
LRR 6 213..234 6/20 (30%)
leucine-rich repeat 214..237 CDD:275380 6/22 (27%)
LRR 7 237..258 7/20 (35%)
leucine-rich repeat 238..261 CDD:275380 9/23 (39%)
LRR 8 261..282 7/20 (35%)
leucine-rich repeat 262..285 CDD:275380 9/22 (41%)
LRRCT 299..346 CDD:214507 12/45 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141312
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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