DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and ELFN2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_443138.2	Gene:	ELFN2 / 114794	HGNCID:	29396	Length:	820	Species:	Homo sapiens

Alignment Length:	921	Identity:	196/921 - (21%)
Similarity:	293/921 - (31%)	Gaps:	325/921 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLCCCSQLGQLRAECPAVCECKW--KSGKESV---LCLNANLTH--IPQPLDAGTQLLDLSGNEI 122
            |||.| :.|.:||:|       |  :..|..|   :|......:  |||.:::....|.|:.|::
Human    11 LLCVC-RPGAVRADC-------WLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKL 67

  Fly   123 QLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELR 187
            :.:...|.  .:..||..:.|.:..:..||..||....:|..|.|..|.||.:....|..:|.|:
Human    68 KAVLYSSL--NRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQ 130

  Fly   188 ELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGT 252
            .|.:..|.|..|...||...|.|:.::||..|||                 :|||        .|
Human   131 FLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLS-----------------RLDG--------AT 170

  Fly   253 ITSLASLHGLELARNTWNCSCSLRPLRAWMLQ-QNIPSGIPP-TCESP------PRLSGRAWDKL 309
            ..|||||...|||.|.:||.|.|....||::. .|:...... .||||      |.|..|.:..|
Human   171 FASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSL 235

  Fly   310 DV----------------------------------------DDFACV--PQIVATDTTA----- 327
            :.                                        |:...|  |....||.:|
Human   236 NAITVLQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIK 300

  Fly   328 -HGVEGRNITMSCYVEGVPQPAVK---------------WLLKNRL-IANLSAGGDGDSDSEPRT 375
             |.|   ..|.:..|..:|.|..|               ..|||:. |..|.           :.
Human   301 LHHV---TFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTLD-----------KL 351

  Fly   376 AAATQGRKTYVVNMLRNAS--NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWG 438
            .|.|:  .|:.|..|||:.  |.|.||...:|.         ..|.:..|.:....
Human   352 RAHTE--YTFCVTSLRNSRRFNHTCLTFTTRDP---------VPGDLAPSTSTTTH--------- 396

  Fly   439 VRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGG 503
            ..:.:||.:..:::|.|:.:  .||    |:|:::           |..:|.....:|..::..|
Human   397 YIMTILGCLFGMVIVLGAVY--YCL----RKRRMQ-----------EEKQKSVNVKKTILEMRYG 444

  Fly   504 ASCGGGSATGAGLFHDAEEQG------YLRAAHTPLNDND-----AGQAAAIVNPSAGSAQRRNG 557
            |....||     :.|.|::.|      ..|.|..|....:     .|..|.:..|...:    .|
Human   445 ADVDAGS-----IVHAAQKLGEPPVLPVSRMASIPSMIGEKLPTAKGLEAGLDTPKVAT----KG 500

  Fly   558 DYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETD 622
            :|:.|.|                                           .|.|...:.|  |.|
Human   501 NYIEVRT-------------------------------------------GAGGDGLARP--EDD 520

  Fly   623 LHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSP--------------- 672
            |  |.|.:..|:.:..|:|:.:||...::....        |...|::|.
Human   521 L--PDLENGQGSAAEISTIAKEVDKVNQIINNC--------IDALKLDSASFLGGGSSSGDPELA 575

  Fly   673 ---HSKPVTSAAPSSLNTQA--------TPYAHYGNHP------ADEMATSVFCSEGQESDLFDS 720
               .|.|..:||.|:....|        .||....:||      ||...|...||......:..:
Human   576 FECQSLPAAAAASSATGPGALERPSFLSPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSA 640

  Fly   721 NYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSG------------------ 767
            .... ||:..:..|....:|..: |.:..:..|..|..||.....||
Human   641 KVFS-LDVPDHPAATGLAKGDSK-YIEKGSPLNSPLDRLPLVPAGSGGGSGGGGGIHHLEVKPAY 703

  Fly   768 -----------KYFRNSSDSQS-------PLL-ADNSSKYGSSTLGDGSFLNEAMGLGRRYSAES 813
                       .|:...:||.|       ||. :...|.|  |.|....:          ||..|
Human   704 HCSEHRHSFPALYYEEGADSLSQRVSFLKPLTRSKRDSTY--SQLSPRHY----------YSGYS 756

  Fly   814 SYANYSSTATY 824
            |...|||.:|:
Human   757 SSPEYSSESTH 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	45/156 (29%)
		leucine-rich repeat	112..137	CDD:275380	4/24 (17%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	18/60 (30%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	17/96 (18%)
		IG_like	328..428	CDD:214653	26/117 (22%)
		Ig	335..425	CDD:143165	24/107 (22%)
ELFN2	NP_443138.2	LRR 1	56..77		4/22 (18%)
		leucine-rich repeat	60..80	CDD:275378	4/21 (19%)
		LRR_8	80..139	CDD:316378	18/58 (31%)
		LRR 2	80..101		7/20 (35%)
		leucine-rich repeat	81..104	CDD:275378	6/22 (27%)
		LRR 3	104..125		7/20 (35%)
		leucine-rich repeat	105..128	CDD:275378	7/22 (32%)
		LRR_8	127..187	CDD:316378	28/84 (33%)
		LRR 4	128..149		7/20 (35%)
		leucine-rich repeat	129..152	CDD:275378	7/22 (32%)
		LRR 5	152..173		10/45 (22%)
		leucine-rich repeat	153..166	CDD:275378	6/29 (21%)
		PCC	157..>227	CDD:188093	30/94 (32%)
		leucine-rich repeat	200..226	CDD:275380	5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..294		5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..527		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..612		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..677		4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930