DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek3 and Lgr4

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_766259.2 Gene:Lgr4 / 107515 MGIID:1891468 Length:951 Species:Mus musculus


Alignment Length:256 Identity:85/256 - (33%)
Similarity:115/256 - (44%) Gaps:15/256 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 LPLHLHLL----LWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLL 115
            :|..|.||    |.||......|.....|.|.|.|   .|...|.|....||.:|:.|.|.||.|
Mouse     1 MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSC---DGDRRVDCSGKGLTAVPEGLSAFTQAL 62

  Fly   116 DLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLAL 180
            |:|.|.|..:|:|:|.....  |:::.||...|..|...|...|..|..|.|..|.|..:||.|:
Mouse    63 DISMNNITQLPEDAFKNFPF--LEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAI 125

  Fly   181 YHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRL 245
            ..:|.|:.|||..|.|..||:|:|..:.||..|.|.|..|:.:.||..:.| .:|:.|.|..|.:
Mouse   126 RGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNILTEVPVRPLSNL-PTLQALTLALNNI 189

  Fly   246 SEVRSGTITSLASLHGLELARN-----TWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRL 301
            |.:.....|:|:||..|.|..|     :.:|...|..|....|..|.....|...::.|.|
Mouse   190 SSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSL 250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 57/156 (37%)
leucine-rich repeat 112..137 CDD:275380 10/24 (42%)
LRR_8 137..196 CDD:290566 21/58 (36%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 24/60 (40%)
leucine-rich repeat 186..209 CDD:275380 10/22 (45%)
leucine-rich repeat 210..234 CDD:275380 8/23 (35%)
leucine-rich repeat 235..258 CDD:275380 7/22 (32%)
LRRCT 267..316 CDD:214507 9/40 (23%)
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
Lgr4NP_766259.2 LRRNT 29..61 CDD:214470 13/34 (38%)
LRR 1 58..79 10/20 (50%)
leucine-rich repeat 59..82 CDD:275380 10/22 (45%)
LRR 2 82..103 6/22 (27%)
LRR_RI 83..375 CDD:238064 55/169 (33%)
LRR_8 83..141 CDD:290566 21/57 (37%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
LRR 3 106..127 8/20 (40%)
leucine-rich repeat 107..130 CDD:275380 8/22 (36%)
LRR 4 130..151 10/20 (50%)
leucine-rich repeat 131..154 CDD:275380 10/22 (45%)
LRR 5 154..177 9/23 (39%)
leucine-rich repeat 155..178 CDD:275380 8/23 (35%)
LRR_8 177..237 CDD:290566 17/59 (29%)
LRR 6 178..199 5/20 (25%)
leucine-rich repeat 179..202 CDD:275380 7/22 (32%)
LRR 7 202..223 6/20 (30%)
leucine-rich repeat 203..226 CDD:275380 6/22 (27%)
LRR 8 226..247 4/20 (20%)
leucine-rich repeat 227..249 CDD:275380 4/21 (19%)
LRR_8 248..305 CDD:290566 2/3 (67%)
LRR 9 249..270 1/2 (50%)
leucine-rich repeat 250..273 CDD:275380 1/1 (100%)
LRR_8 272..355 CDD:290566
LRR 10 273..294
leucine-rich repeat 274..295 CDD:275380
LRR 11 320..341
leucine-rich repeat 321..344 CDD:275380
LRR 12 344..365
leucine-rich repeat 345..366 CDD:275380
LRR_8 365..425 CDD:290566
LRR 13 366..387
leucine-rich repeat 367..390 CDD:275380
LRR 388..410 CDD:197688
LRR 14 390..411
leucine-rich repeat 391..414 CDD:275380
LRR 15 414..435
leucine-rich repeat 415..438 CDD:275380
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..512
7tm_1 556..801 CDD:278431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831259
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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